| November 14, 2042 | OHIO STATE BUCKEYES | W 88-57 | 1-0 | B. Grossman 19 | K. Petteway 6 | B. Grossman 8 |
| November 18, 2042 | @ #13 Texas Longhorns | L 68-83 | 1-1 | I. Thomas 14 | C. Hines 4 | I. Thomas 10 |
| November 21, 2042 | BUFFALO BULLS | W 80-61 | 2-1 | M. Carver 21 | C. Hines 5 | M. Carver 8 |
| November 24, 2042 | @ Oklahoma Sooners | L 50-67 | 2-2 | B. Grossman 9 | C. Hines 2 | B. Grossman 10 |
| November 28, 2042 | @ Arkansas Razorbacks | L 71-92 | 2-3 | E. Rabey 12 | K. Petteway 4 | M. Carver 8 |
| December 1, 2042 | DUKE BLUE DEVILS | L 79-80 | 2-4 | R. Higgins 18 | E. Rabey 4 | B. Grossman 10 |
| December 5, 2042 | IONA GAELS | W 84-73 | 3-4 | B. Grossman 26 | C. Hines 5 | R. Higgins 6 |
| December 13, 2042 | SAN DIEGO STATE AZTECS | L 72-76 | 3-5 | B. Grossman 14 | L. Bowden 2 | M. Carver 7 |
| December 21, 2042 | @ #17 Louisville Cardinals | L 87-94 | 3-6 | R. Higgins 17 | B. Grossman 4 | R. Higgins 6 |
| December 26, 2042 | #1 BAYLOR BEARS* | L 73-88 | 3-7 | M. Carver 14 | B. Grossman 5 | B. Grossman 7 |
| December 30, 2042 | @ TCU Horned Frogs* | L 70-105 | 3-8 | C. Clark 12 | C. Hines 4 | B. Grossman 6 |
| January 4, 2043 | #24 HOUSTON COUGARS* | L 60-77 | 3-9 | B. Grossman 20 | C. Hines 3 | M. Carver 13 |
| January 6, 2043 | @ Utah Utes* | L 76-90 | 3-10 | R. Higgins 13 | E. Rabey 5 | R. Higgins 6 |
| January 9, 2043 | @ #3 Kansas Jayhawks* | L 52-76 | 3-11 | E. Rabey 9 | C. Clark 5 | M. Carver 10 |
| January 13, 2043 | KANSAS STATE WILDCATS* | L 64-78 | 3-12 | I. Thomas 19 | C. Hines 3 | I. Thomas 8 |
| January 18, 2043 | CINCINNATI BEARCATS* | L 59-66 | 3-13 | B. Grossman 14 | C. Hines 3 | M. Carver 11 |
| January 23, 2043 | @ BYU Cougars* | L 85-95 | 3-14 | R. Higgins 13 | E. Rabey 5 | J. Joseph 6 |
| January 25, 2043 | @ Houston Cougars* | L 69-93 | 3-15 | K. Petteway 20 | K. Petteway 3 | R. Higgins 9 |
| January 27, 2043 | UTAH UTES* | W 84-80 | 4-15 | M. Carver 16 | K. Petteway 5 | M. Carver 9 |
| February 1, 2043 | @ #2 Baylor Bears* | L 68-94 | 4-16 | J. Joseph 17 | C. Hines 4 | M. Carver 10 |
| February 6, 2043 | IOWA STATE CYCLONES* | W 78-70 | 5-16 | E. Rabey 20 | K. Petteway 9 | M. Carver 14 |
| February 8, 2043 | @ Arizona State Sun Devils* | L 71-83 | 5-17 | M. Carver 15 | K. Petteway 4 | J. Joseph 7 |
| February 10, 2043 | BYU COUGARS* | L 76-82 | 5-18 | I. Thomas 15 | K. Petteway 4 | M. Carver 6 |
| February 15, 2043 | #12 WEST VIRGINIA MOUNTAINEERS* | L 70-81 | 5-19 | E. Ramirez 13 | K. Petteway 6 | E. Rabey 5 |
| February 17, 2043 | @ UCF Knights* | L 64-94 | 5-20 | I. Thomas 14 | C. Hines 3 | M. Carver 8 |
| February 22, 2043 | TEXAS TECH RED RAIDERS* | L 72-85 | 5-21 | M. Carver 16 | K. Petteway 5 | R. Higgins 5 |
| February 24, 2043 | @ Colorado Buffaloes* | L 67-81 | 5-22 | M. Carver 13 | K. Petteway 5 | M. Carver 9 |
| March 1, 2043 | @ #10 West Virginia Mountaineers* | L 55-76 | 5-23 | R. Higgins 18 | K. Petteway 3 | M. Carver 6 |
| March 3, 2043 | OKLAHOMA STATE COWBOYS* | L 76-93 | 5-24 | K. Petteway 14 | K. Petteway 4 | E. Rabey 3 |
| March 8, 2043 | @ UCF Knights Big 12 Tournament | L 71-88 | 5-25 | M. Carver 13 | K. Petteway 3 | I. Thomas 8 |
