| November 14, 2042 | OHIO STATE BUCKEYES | W 88-57 | 1-0 | B. Grossman 19 | K. Petteway 6 | B. Grossman 8 |
| November 18, 2042 | @ #13 Texas Longhorns | L 68-83 | 1-1 | I. Thomas 14 | C. Hines 4 | I. Thomas 10 |
| November 21, 2042 | BUFFALO BULLS | W 80-61 | 2-1 | M. Carver 21 | C. Hines 5 | M. Carver 8 |
| November 24, 2042 | @ Oklahoma Sooners | L 50-67 | 2-2 | B. Grossman 9 | C. Hines 2 | B. Grossman 10 |
| November 28, 2042 | @ Arkansas Razorbacks | L 71-92 | 2-3 | E. Rabey 12 | K. Petteway 4 | M. Carver 8 |
| December 1, 2042 | DUKE BLUE DEVILS | L 79-80 | 2-4 | R. Higgins 18 | E. Rabey 4 | B. Grossman 10 |
| December 5, 2042 | IONA GAELS | W 84-73 | 3-4 | B. Grossman 26 | C. Hines 5 | R. Higgins 6 |
| December 13, 2042 | SAN DIEGO STATE AZTECS | L 72-76 | 3-5 | B. Grossman 14 | L. Bowden 2 | M. Carver 7 |
| December 21, 2042 | @ #17 Louisville Cardinals | L 87-94 | 3-6 | R. Higgins 17 | B. Grossman 4 | R. Higgins 6 |
| December 26, 2042 | BAYLOR BEARS (11-1, 0-0, 1-0 Away)* | - | | | | |
| December 30, 2042 | @ TCU Horned Frogs (7-3, 0-0, 6-0 Home)* | - | | | | |
| January 4, 2043 | HOUSTON COUGARS (7-2, 0-0, 0-2 Away)* | - | | | | |
| January 6, 2043 | @ Utah Utes (7-4, 0-0, 5-3 Home)* | - | | | | |
| January 9, 2043 | @ Kansas Jayhawks (10-1, 0-0, 6-0 Home)* | - | | | | |
| January 13, 2043 | KANSAS STATE WILDCATS (5-5, 0-0, 1-1 Away)* | - | | | | |
| January 18, 2043 | CINCINNATI BEARCATS (8-2, 0-0, 0-0 Away)* | - | | | | |
| January 23, 2043 | @ BYU Cougars (7-3, 0-0, 5-0 Home)* | - | | | | |
| January 25, 2043 | @ Houston Cougars (7-2, 0-0, 7-0 Home)* | - | | | | |
| January 27, 2043 | UTAH UTES (7-4, 0-0, 0-0 Away)* | - | | | | |
| February 1, 2043 | @ Baylor Bears (11-1, 0-0, 7-0 Home)* | - | | | | |
| February 6, 2043 | IOWA STATE CYCLONES (2-7, 0-0, 0-2 Away)* | - | | | | |
| February 8, 2043 | @ Arizona State Sun Devils (7-3, 0-0, 5-2 Home)* | - | | | | |
| February 10, 2043 | BYU COUGARS (7-3, 0-0, 1-2 Away)* | - | | | | |
| February 15, 2043 | WEST VIRGINIA MOUNTAINEERS (9-2, 0-0, 0-1 Away)* | - | | | | |
| February 17, 2043 | @ UCF Knights (5-4, 0-0, 5-0 Home)* | - | | | | |
| February 22, 2043 | TEXAS TECH RED RAIDERS (6-4, 0-0, 1-2 Away)* | - | | | | |
| February 24, 2043 | @ Colorado Buffaloes (6-4, 0-0, 4-2 Home)* | - | | | | |
| March 1, 2043 | @ West Virginia Mountaineers (9-2, 0-0, 6-1 Home)* | - | | | | |
| March 3, 2043 | OKLAHOMA STATE COWBOYS (10-1, 0-0, 0-0 Away)* | - | | | | |
