| November 15, 2039 |  NORTHWESTERN WILDCATS | W 74-65 | 1-0 | H. Underwood 14 | H. Underwood 4 | T. Bivins 9 |
| November 17, 2039 |  LOYOLA CHICAGO RAMBLERS | W 81-58 | 2-0 | D. Jefferson 15 | D. Jefferson 7 | D. Jefferson 6 |
| November 21, 2039 |  @ Arizona State Sun Devils  Charleston Classic | L 74-84 | 2-1 | D. Jefferson 20 | C. Mouring 4 | B. Jensen 7 |
| November 25, 2039 |  @ #3 Colorado Buffaloes | L 63-88 | 2-2 | D. Jefferson 26 | H. Underwood 6 | C. Mouring 7 |
| November 30, 2039 |  @ #14 Texas Longhorns | L 56-82 | 2-3 | B. Jensen 15 | H. Underwood 5 | B. Jensen 10 |
| December 2, 2039 |  NORTHEASTERN HUSKIES | W 76-59 | 3-3 | B. Jensen 15 | H. Underwood 6 | S. Charles 13 |
| December 10, 2039 |  GONZAGA BULLDOGS | L 52-68 | 3-4 | D. Jefferson 16 | G. Curry 4 | D. Jefferson 5 |
| December 13, 2039 |  UMASS MINUTEMEN | W 80-59 | 4-4 | C. Mouring 12 | S. Charles 4 | C. Mouring 9 |
| December 20, 2039 |  @ #9 Wichita State Shockers | L 63-93 | 4-5 | V. Lavin 18 | H. Underwood 5 | S. Charles 6 |
| December 28, 2039 |  @ #14 Louisville Cardinals* | L 57-70 | 4-6 | V. Lavin 16 | G. Curry 4 | C. Mouring 9 |
| December 30, 2039 |  WAKE FOREST DEMON DEACONS* | L 63-65 | 4-7 | D. Jefferson 11 | H. Underwood 6 | C. Mouring 11 |
| January 2, 2040 |  @ Clemson Tigers* | L 71-90 | 4-8 | D. Jefferson 18 | H. Underwood 8 | S. Charles 4 |
| January 9, 2040 |  VIRGINIA TECH HOKIES* | W 70-53 | 5-8 | D. Jefferson 18 | H. Underwood 6 | C. Mouring 9 |
| January 11, 2040 |  @ #11 Florida State Seminoles* | L 58-84 | 5-9 | D. Jefferson 17 | V. Lavin 3 | S. Charles 5 |
| January 13, 2040 |  #2 NORTH CAROLINA TAR HEELS* | L 72-76 | 5-10 | D. Jefferson 18 | D. Jefferson 4 | C. Mouring 9 |
| January 18, 2040 | @ Wake Forest Demon Deacons* | L 64-76 | 5-11 | D. Jefferson 15 | D. Jefferson 5 | C. Mouring 6 |
| January 20, 2040 |  @ Pittsburgh Panthers* | L 61-80 | 5-12 | B. Jensen 20 | H. Underwood 6 | C. Mouring 11 |
| January 25, 2040 |  GEORGIA TECH YELLOW JACKETS* | W 70-54 | 6-12 | B. Jensen 22 | H. Underwood 5 | S. Charles 8 |
| January 30, 2040 | @ Virginia Tech Hokies* | W 74-63 | 7-12 | C. Mouring 19 | H. Underwood 6 | S. Charles 9 |
| February 1, 2040 | #21 FLORIDA STATE SEMINOLES* | W 67-57 OT | 8-12 | D. Jefferson 19 | D. Jefferson 5 | C. Mouring 8 |
| February 3, 2040 | @ #1 North Carolina Tar Heels* | L 61-80 | 8-13 | D. Jefferson 16 | C. Mouring 4 | C. Mouring 12 |
| February 8, 2040 |  #6 MIAMI (FL) HURRICANES* | L 65-87 | 8-14 | C. Mouring 20 | H. Underwood 4 | C. Mouring 6 |
| February 10, 2040 |  VIRGINIA CAVALIERS* | L 63-75 | 8-15 | H. Underwood 18 | C. Mouring 4 | B. Jensen 7 |
| February 13, 2040 | CLEMSON TIGERS* | W 87-76 | 9-15 | H. Underwood 23 | D. Jefferson 5 | B. Jensen 7 |
| February 15, 2040 | @ Georgia Tech Yellow Jackets* | L 90-91 | 9-16 | D. Jefferson 21 | D. Jefferson 5 | C. Mouring 5 |
| February 20, 2040 |  @ Duke Blue Devils* | W 69-65 | 10-16 | B. Jensen 25 | C. Mouring 3 | C. Mouring 10 |
| February 24, 2040 |  @ Syracuse Orange* | L 63-72 | 10-17 | C. Mouring 19 | C. Mouring 5 | C. Mouring 7 |
| March 1, 2040 |  #15 NOTRE DAME FIGHTING IRISH* | L 65-84 | 10-18 | S. Charles 13 | G. Curry 6 | T. Bivins 7 |
| March 3, 2040 |  NC STATE WOLFPACK* | L 77-83 | 10-19 | C. Mouring 17 | H. Underwood 5 | C. Mouring 9 |
| March 8, 2040 | @ Clemson Tigers  ACC Tournament | L 96-97 OT | 10-20 | D. Jefferson 24 | S. Charles 5 | B. Jensen 9 |
