| November 16, 2042 | SOUTHERN MISS GOLDEN EAGLES | W 87-68 | 1-0 | E. Irvin 13 | L. Jefferson 3 | A. Peppers 8 |
| November 19, 2042 | OLD DOMINION MONARCHS | L 78-98 | 1-1 | V. Cloud 26 | R. Arnold 6 | G. Cottrell 6 |
| November 25, 2042 | GEORGE MASON PATRIOTS US Virgin Islands Paradise Jam | L 79-80 | 1-2 | V. Cloud 24 | A. Peppers 5 | L. Jefferson 8 |
| November 29, 2042 | FLORIDA GATORS | W 91-71 | 2-2 | V. Cloud 19 | R. Arnold 8 | G. Cottrell 10 |
| December 3, 2042 | @ #21 Butler Bulldogs | L 69-94 | 2-3 | G. Denny 19 | R. Arnold 6 | A. Peppers 11 |
| December 7, 2042 | NORTHERN KENTUCKY NORSE | L 62-73 | 2-4 | A. Peppers 16 | R. Arnold 5 | A. Peppers 13 |
| December 10, 2042 | PENNSYLVANIA QUAKERS | L 63-68 | 2-5 | G. Denny 17 | R. Arnold 7 | G. Denny 8 |
| December 13, 2042 | @ Harvard Crimson | W 87-74 | 3-5 | A. Peppers 19 | R. Arnold 9 | L. Jefferson 9 |
| December 16, 2042 | @ Missouri Tigers | L 73-90 | 3-6 | A. Peppers 16 | T. Bautista 3 | A. Peppers 10 |
| December 26, 2042 | @ #12 Louisville Cardinals* | L 71-94 | 3-7 | V. Cloud 20 | R. Arnold 8 | A. Peppers 9 |
| December 28, 2042 | @ California Golden Bears* | L 72-74 | 3-8 | A. Peppers 23 | R. Arnold 7 | V. Cloud 7 |
| January 2, 2043 | #7 STANFORD CARDINAL* | L 74-82 | 3-9 | G. Cottrell 20 | R. Arnold 8 | A. Peppers 7 |
| January 4, 2043 | @ Clemson Tigers* | L 66-92 | 3-10 | A. Peppers 16 | G. Cottrell 3 | G. Denny 12 |
| January 9, 2043 | GEORGIA TECH YELLOW JACKETS* | W 79-77 | 4-10 | A. Peppers 21 | R. Arnold 4 | R. Arnold 8 |
| January 11, 2043 | @ Pittsburgh Panthers* | L 77-82 | 4-11 | R. Arnold 20 | R. Arnold 5 | G. Denny 9 |
| January 16, 2043 | NC STATE WOLFPACK* | L 69-75 | 4-12 | V. Cloud 13 | R. Arnold 5 | A. Peppers 9 |
| January 18, 2043 | @ Wake Forest Demon Deacons* | W 86-78 OT | 5-12 | A. Peppers 22 | R. Arnold 8 | A. Peppers 12 |
| January 23, 2043 | SYRACUSE ORANGE* | L 67-80 | 5-13 | V. Cloud 22 | R. Arnold 7 | R. Arnold 6 |
| January 25, 2043 | #2 NORTH CAROLINA TAR HEELS* | L 53-68 | 5-14 | V. Cloud 18 | R. Arnold 3 | A. Peppers 9 |
| January 30, 2043 | @ #12 Notre Dame Fighting Irish* | L 70-82 | 5-15 | A. Peppers 21 | R. Arnold 5 | G. Denny 6 |
| February 1, 2043 | DUKE BLUE DEVILS* | W 91-72 | 6-15 | V. Cloud 22 | R. Arnold 6 | G. Cottrell 9 |
| February 6, 2043 | VIRGINIA TECH HOKIES* | W 89-69 | 7-15 | R. Arnold 16 | R. Arnold 5 | A. Peppers 8 |
| February 8, 2043 | @ Miami (FL) Hurricanes* | L 74-95 | 7-16 | A. Peppers 17 | R. Arnold 4 | A. Peppers 6 |
| February 13, 2043 | SMU MUSTANGS (13-11, 7-7, 3-6 Away)* | - | | | | |
| February 15, 2043 | @ Florida State Seminoles (14-9, 7-7, 11-2 Home)* | - | | | | |
| February 20, 2043 | VIRGINIA CAVALIERS (9-14, 7-7, 3-9 Away)* | - | | | | |
| February 22, 2043 | MIAMI (FL) HURRICANES (16-9, 7-7, 2-7 Away)* | - | | | | |
| February 27, 2043 | @ SMU Mustangs (13-11, 7-7, 9-4 Home)* | - | | | | |
| March 1, 2043 | @ Stanford Cardinal (20-6, 9-5, 11-2 Home)* | - | | | | |
