| November 16, 2042 | SOUTHERN MISS GOLDEN EAGLES | W 87-68 | 1-0 | E. Irvin 13 | L. Jefferson 3 | A. Peppers 8 |
| November 19, 2042 | OLD DOMINION MONARCHS | L 78-98 | 1-1 | V. Cloud 26 | R. Arnold 6 | G. Cottrell 6 |
| November 25, 2042 | GEORGE MASON PATRIOTS US Virgin Islands Paradise Jam | L 79-80 | 1-2 | V. Cloud 24 | A. Peppers 5 | L. Jefferson 8 |
| November 29, 2042 | FLORIDA GATORS | W 91-71 | 2-2 | V. Cloud 19 | R. Arnold 8 | G. Cottrell 10 |
| December 3, 2042 | @ #21 Butler Bulldogs | L 69-94 | 2-3 | G. Denny 19 | R. Arnold 6 | A. Peppers 11 |
| December 7, 2042 | NORTHERN KENTUCKY NORSE | L 62-73 | 2-4 | A. Peppers 16 | R. Arnold 5 | A. Peppers 13 |
| December 10, 2042 | PENNSYLVANIA QUAKERS | L 63-68 | 2-5 | G. Denny 17 | R. Arnold 7 | G. Denny 8 |
| December 13, 2042 | @ Harvard Crimson | W 87-74 | 3-5 | A. Peppers 19 | R. Arnold 9 | L. Jefferson 9 |
| December 16, 2042 | @ Missouri Tigers | L 73-90 | 3-6 | A. Peppers 16 | T. Bautista 3 | A. Peppers 10 |
| December 26, 2042 | @ Louisville Cardinals (9-2, 0-0, 4-1 Home)* | - | | | | |
| December 28, 2042 | @ California Golden Bears (1-8, 0-0, 1-4 Home)* | - | | | | |
| January 2, 2043 | STANFORD CARDINAL (11-1, 0-0, 1-1 Away)* | - | | | | |
| January 4, 2043 | @ Clemson Tigers (2-7, 0-0, 1-3 Home)* | - | | | | |
| January 9, 2043 | GEORGIA TECH YELLOW JACKETS (8-3, 0-0, 2-2 Away)* | - | | | | |
| January 11, 2043 | @ Pittsburgh Panthers (7-4, 0-0, 4-1 Home)* | - | | | | |
| January 16, 2043 | NC STATE WOLFPACK (6-3, 0-0, 0-2 Away)* | - | | | | |
| January 18, 2043 | @ Wake Forest Demon Deacons (3-7, 0-0, 0-3 Home)* | - | | | | |
| January 23, 2043 | SYRACUSE ORANGE (6-3, 0-0, 1-1 Away)* | - | | | | |
| January 25, 2043 | NORTH CAROLINA TAR HEELS (10-1, 0-0, 2-1 Away)* | - | | | | |
| January 30, 2043 | @ Notre Dame Fighting Irish (8-4, 0-0, 4-1 Home)* | - | | | | |
| February 1, 2043 | DUKE BLUE DEVILS (5-4, 0-0, 1-2 Away)* | - | | | | |
| February 6, 2043 | VIRGINIA TECH HOKIES (4-6, 0-0, 0-2 Away)* | - | | | | |
| February 8, 2043 | @ Miami (FL) Hurricanes (9-2, 0-0, 5-0 Home)* | - | | | | |
| February 13, 2043 | SMU MUSTANGS (6-4, 0-0, 0-1 Away)* | - | | | | |
| February 15, 2043 | @ Florida State Seminoles (7-2, 0-0, 7-0 Home)* | - | | | | |
| February 20, 2043 | VIRGINIA CAVALIERS (2-7, 0-0, 1-4 Away)* | - | | | | |
| February 22, 2043 | MIAMI (FL) HURRICANES (9-2, 0-0, 2-1 Away)* | - | | | | |
| February 27, 2043 | @ SMU Mustangs (6-4, 0-0, 5-2 Home)* | - | | | | |
| March 1, 2043 | @ Stanford Cardinal (11-1, 0-0, 6-0 Home)* | - | | | | |
