| November 14, 2042 | COPPIN STATE EAGLES NIT Season Tip-Off | W 84-78 | 1-0 | D. Kelley 45 | J. Riley 5 | J. Riley 10 |
| November 16, 2042 | #20 SAINT MARY'S GAELS NIT Season Tip-Off | L 80-82 | 1-1 | J. Riley 19 | D. Kelley 6 | J. Riley 8 |
| November 23, 2042 | EAST CAROLINA PIRATES | W 84-67 | 2-1 | M. Ross 16 | J. Riley 7 | M. Ross 12 |
| November 26, 2042 | #21 CHARLOTTE 49ERS | W 93-77 | 3-1 | D. Kelley 24 | A. Pierre 5 | A. Johns 16 |
| November 30, 2042 | SANTA CLARA BRONCOS | L 83-94 | 3-2 | D. Kelley 25 | J. Riley 9 | D. Kelley 6 |
| December 3, 2042 | BOSTON COLLEGE EAGLES | W 94-69 | 4-2 | D. Kelley 37 | A. Pierre 7 | J. Riley 11 |
| December 7, 2042 | @ #16 LSU Tigers | L 78-84 | 4-3 | D. Kelley 37 | A. Pierre 3 | D. Kelley 10 |
| December 13, 2042 | @ #15 Purdue Boilermakers | L 63-71 | 4-4 | J. Riley 19 | A. Pierre 7 | A. Johns 12 |
| December 17, 2042 | @ Virginia Cavaliers | W 96-62 | 5-4 | D. Kelley 22 | M. Ross 4 | M. Harper 7 |
| December 21, 2042 | TOLEDO ROCKETS | W 86-69 | 6-4 | D. Kelley 34 | A. Pierre 5 | A. Johns 15 |
| December 28, 2042 | SETON HALL PIRATES* | W 94-80 | 7-4 | D. Kelley 23 | A. Pierre 5 | B. Self 10 |
| December 30, 2042 | MARQUETTE GOLDEN EAGLES* | W 89-79 | 8-4 | J. Riley 22 | J. Riley 5 | J. Riley 9 |
| January 2, 2043 | @ #18 Creighton Blue Jays* | W 86-83 OT | 9-4 | D. Kelley 29 | A. Pierre 7 | A. Johns 9 |
| January 4, 2043 | @ Georgetown Hoyas* | W 75-63 | 10-4 | D. Kelley 35 | A. Pierre 4 | D. Kelley 10 |
| January 11, 2043 | VILLANOVA WILDCATS* | W 88-60 | 11-4 | D. Kelley 19 | A. Pierre 6 | D. Kelley 8 |
| January 13, 2043 | CONNECTICUT HUSKIES* | W 93-77 | 12-4 | D. Kelley 17 | A. Pierre 4 | J. Riley 9 |
| January 20, 2043 | @ DePaul Blue Demons* | W 72-59 | 13-4 | D. Kelley 20 | M. Maye 5 | M. Maye 6 |
| January 23, 2043 | @ Xavier Musketeers* | W 92-66 | 14-4 | D. Kelley 30 | D. Kelley 7 | D. Kelley 8 |
| January 25, 2043 | ST. JOHN'S RED STORM* | W 83-69 | 15-4 | D. Kelley 36 | A. Pierre 8 | B. Self 10 |
| January 27, 2043 | GEORGETOWN HOYAS* | W 86-63 | 16-4 | D. Kelley 20 | A. Pierre 5 | M. Ross 9 |
| February 1, 2043 | @ Providence Friars* | W 83-69 | 17-4 | D. Kelley 27 | A. Pierre 6 | B. Self 13 |
| February 6, 2043 | #21 CREIGHTON BLUE JAYS* | W 85-71 | 18-4 | D. Kelley 27 | A. Pierre 10 | M. Harper 10 |
| February 8, 2043 | @ Connecticut Huskies* | W 61-57 | 19-4 | D. Kelley 16 | A. Pierre 6 | M. Ross 8 |
| February 10, 2043 | @ Villanova Wildcats* | W 81-60 | 20-4 | M. Maye 17 | A. Pierre 6 | B. Self 10 |
| February 15, 2043 | PROVIDENCE FRIARS (9-14, 5-9, 3-6 Away)* | - | | | | |
| February 17, 2043 | @ St. John's Red Storm (9-17, 3-12, 7-6 Home)* | - | | | | |
| February 22, 2043 | DEPAUL BLUE DEMONS (10-13, 7-6, 3-5 Away)* | - | | | | |
| February 24, 2043 | XAVIER MUSKETEERS (13-11, 5-9, 3-7 Away)* | - | | | | |
| March 1, 2043 | @ Marquette Golden Eagles (14-10, 9-6, 9-4 Home)* | - | | | | |
| March 3, 2043 | @ Seton Hall Pirates (17-6, 9-5, 15-1 Home)* | - | | | | |
