| November 14, 2042 | COPPIN STATE EAGLES NIT Season Tip-Off | W 84-78 | 1-0 | D. Kelley 45 | J. Riley 5 | J. Riley 10 |
| November 16, 2042 | #20 SAINT MARY'S GAELS NIT Season Tip-Off | L 80-82 | 1-1 | J. Riley 19 | D. Kelley 6 | J. Riley 8 |
| November 23, 2042 | EAST CAROLINA PIRATES | W 84-67 | 2-1 | M. Ross 16 | J. Riley 7 | M. Ross 12 |
| November 26, 2042 | #21 CHARLOTTE 49ERS | W 93-77 | 3-1 | D. Kelley 24 | A. Pierre 5 | A. Johns 16 |
| November 30, 2042 | SANTA CLARA BRONCOS | L 83-94 | 3-2 | D. Kelley 25 | J. Riley 9 | D. Kelley 6 |
| December 3, 2042 | BOSTON COLLEGE EAGLES | W 94-69 | 4-2 | D. Kelley 37 | A. Pierre 7 | J. Riley 11 |
| December 7, 2042 | @ #16 LSU Tigers | L 78-84 | 4-3 | D. Kelley 37 | A. Pierre 3 | D. Kelley 10 |
| December 13, 2042 | @ #15 Purdue Boilermakers | L 63-71 | 4-4 | J. Riley 19 | A. Pierre 7 | A. Johns 12 |
| December 17, 2042 | @ Virginia Cavaliers | W 96-62 | 5-4 | D. Kelley 22 | M. Ross 4 | M. Harper 7 |
| December 21, 2042 | TOLEDO ROCKETS | W 86-69 | 6-4 | D. Kelley 34 | A. Pierre 5 | A. Johns 15 |
| December 28, 2042 | SETON HALL PIRATES (8-1, 0-0, 0-1 Away)* | - | | | | |
| December 30, 2042 | MARQUETTE GOLDEN EAGLES (5-4, 0-0, 1-1 Away)* | - | | | | |
| January 2, 2043 | @ Creighton Blue Jays (9-2, 0-0, 3-1 Home)* | - | | | | |
| January 4, 2043 | @ Georgetown Hoyas (2-8, 0-0, 1-1 Home)* | - | | | | |
| January 11, 2043 | VILLANOVA WILDCATS (5-4, 0-0, 1-1 Away)* | - | | | | |
| January 13, 2043 | CONNECTICUT HUSKIES (7-4, 0-0, 1-2 Away)* | - | | | | |
| January 20, 2043 | @ DePaul Blue Demons (3-7, 0-0, 2-5 Home)* | - | | | | |
| January 23, 2043 | @ Xavier Musketeers (8-2, 0-0, 6-0 Home)* | - | | | | |
| January 25, 2043 | ST. JOHN'S RED STORM (6-5, 0-0, 0-3 Away)* | - | | | | |
| January 27, 2043 | GEORGETOWN HOYAS (2-8, 0-0, 0-6 Away)* | - | | | | |
| February 1, 2043 | @ Providence Friars (4-5, 0-0, 3-2 Home)* | - | | | | |
| February 6, 2043 | CREIGHTON BLUE JAYS (9-2, 0-0, 3-1 Away)* | - | | | | |
| February 8, 2043 | @ Connecticut Huskies (7-4, 0-0, 4-1 Home)* | - | | | | |
| February 10, 2043 | @ Villanova Wildcats (5-4, 0-0, 4-2 Home)* | - | | | | |
| February 15, 2043 | PROVIDENCE FRIARS (4-5, 0-0, 1-2 Away)* | - | | | | |
| February 17, 2043 | @ St. John's Red Storm (6-5, 0-0, 4-1 Home)* | - | | | | |
| February 22, 2043 | DEPAUL BLUE DEMONS (3-7, 0-0, 0-1 Away)* | - | | | | |
| February 24, 2043 | XAVIER MUSKETEERS (8-2, 0-0, 1-1 Away)* | - | | | | |
| March 1, 2043 | @ Marquette Golden Eagles (5-4, 0-0, 4-2 Home)* | - | | | | |
| March 3, 2043 | @ Seton Hall Pirates (8-1, 0-0, 8-0 Home)* | - | | | | |
