| November 16, 2042 | PENNSYLVANIA QUAKERS | W 70-53 | 1-0 | C. Thompkins 20 | C. Gann 7 | C. Thompkins 11 |
| November 22, 2042 | @ Tennessee Volunteers | L 71-94 | 1-1 | D. McGrath 12 | C. Gann 6 | C. Goodwin 5 |
| November 30, 2042 | APP STATE MOUNTAINEERS | W 92-67 | 2-1 | L. Kerr 16 | C. Gann 7 | R. Williams 9 |
| December 3, 2042 | GEORGETOWN HOYAS | W 84-64 | 3-1 | C. Thompkins 23 | L. Kerr 3 | C. Goodwin 13 |
| December 5, 2042 | NORTHWESTERN WILDCATS | W 75-60 | 4-1 | C. Goodwin 22 | L. Kerr 3 | C. Goodwin 10 |
| December 10, 2042 | @ Michigan Wolverines | W 82-77 | 5-1 | C. Thompkins 13 | C. Gann 4 | C. Thompkins 10 |
| December 13, 2042 | @ #5 Gonzaga Bulldogs | L 76-79 | 5-2 | L. Kerr 15 | C. Gann 4 | D. McGrath 8 |
| December 19, 2042 | SAN DIEGO TOREROS | W 71-56 | 6-2 | L. Kerr 17 | C. Gann 5 | R. Williams 9 |
| December 23, 2042 | CLEMSON TIGERS Gulf Coast Showcase | W 103-92 | 7-2 | L. Kerr 25 | C. Gann 4 | J. Herron 12 |
| December 24, 2042 | @ Michigan State Spartans Gulf Coast Showcase | L 92-97 | 7-3 | C. Thompkins 21 | C. Gann 4 | C. Thompkins 6 |
| December 28, 2042 | #10 WEST VIRGINIA MOUNTAINEERS* | L 69-81 | 7-4 | L. Kerr 17 | C. Gann 5 | C. Thompkins 8 |
| December 30, 2042 | @ Utah Utes* | L 77-82 | 7-5 | C. Gann 14 | C. Gann 5 | R. Williams 7 |
| January 4, 2043 | @ #4 Kansas Jayhawks* | L 70-92 | 7-6 | C. Thompkins 12 | C. Gann 6 | R. Williams 8 |
| January 6, 2043 | TEXAS TECH RED RAIDERS* | W 91-67 | 8-6 | L. Kerr 23 | C. Gann 13 | J. Herron 8 |
| January 9, 2043 | @ Houston Cougars* | L 72-79 | 8-7 | J. Herron 17 | C. Gann 7 | R. Williams 8 |
| January 13, 2043 | CINCINNATI BEARCATS* | W 96-74 | 9-7 | C. Thompkins 24 | L. Kerr 7 | C. Thompkins 9 |
| January 18, 2043 | @ #15 Oklahoma State Cowboys* | L 69-87 | 9-8 | C. Thompkins 17 | C. Gann 5 | C. Thompkins 8 |
| January 23, 2043 | ARIZONA WILDCATS* | W 95-85 | 10-8 | C. Thompkins 20 | C. Gann 7 | J. Herron 8 |
| January 25, 2043 | ARIZONA STATE SUN DEVILS* | W 74-62 | 11-8 | C. Thompkins 20 | C. Gann 5 | L. Kerr 8 |
| January 27, 2043 | @ #1 Baylor Bears* | W 86-85 | 12-8 | C. Thompkins 20 | C. Gann 6 | L. Kerr 6 |
| February 1, 2043 | COLORADO BUFFALOES* | L 85-87 | 12-9 | L. Kerr 22 | L. Kerr 3 | C. Thompkins 8 |
| February 3, 2043 | @ Cincinnati Bearcats* | W 92-76 | 13-9 | J. Herron 21 | C. Gann 5 | C. Goodwin 8 |
| February 8, 2043 | IOWA STATE CYCLONES* | W 89-69 | 14-9 | C. Thompkins 23 | C. Gann 8 | R. Williams 11 |
| February 10, 2043 | @ Arizona Wildcats* | W 82-76 | 15-9 | L. Kerr 23 | C. Gann 8 | L. Heward 9 |
| February 15, 2043 | @ Arizona State Sun Devils (15-9, 8-6, 10-4 Home)* | - | | | | |
| February 17, 2043 | TCU HORNED FROGS (15-9, 8-6, 3-6 Away)* | - | | | | |
| February 20, 2043 | BAYLOR BEARS (23-3, 12-2, 7-1 Away)* | - | | | | |
| February 24, 2043 | @ UCF Knights (14-9, 9-5, 11-1 Home)* | - | | | | |
| March 1, 2043 | KANSAS STATE WILDCATS (11-14, 6-8, 4-5 Away)* | - | | | | |
| March 3, 2043 | @ Iowa State Cyclones (3-20, 1-13, 3-10 Home)* | - | | | | |
