| November 16, 2042 | GRAND CANYON ANTELOPES | W 84-72 | 1-0 | J. Brown 20 | R. Darnell 4 | L. Patrick 9 |
| November 19, 2042 | MOREHEAD STATE EAGLES | L 73-79 | 1-1 | L. Patrick 22 | R. Darnell 7 | L. Patrick 6 |
| November 23, 2042 | QUINNIPIAC BOBCATS | L 63-91 | 1-2 | L. Patrick 16 | R. Darnell 6 | J. Brown 7 |
| November 25, 2042 | @ Texas Longhorns | L 57-79 | 1-3 | W. Prescott 19 | R. Darnell 4 | L. Sawyer 9 |
| November 30, 2042 | @ Charleston Cougars | L 57-75 | 1-4 | J. Brown 16 | R. Darnell 2 | J. Brown 8 |
| December 7, 2042 | UNC ASHEVILLE BULLDOGS | L 90-97 OT | 1-5 | L. Patrick 23 | R. Darnell 9 | J. Brown 7 |
| December 13, 2042 | @ #19 Saint Mary's Gaels | L 68-87 | 1-6 | J. Brown 12 | R. Darnell 4 | W. Prescott 3 |
| December 21, 2042 | MANHATTAN JASPERS | L 83-92 | 1-7 | J. Brown 15 | R. Darnell 5 | J. Brown 5 |
| December 23, 2042 | UTSA ROADRUNNERS saatva Empire Classic | L 80-88 | 1-8 | W. Prescott 17 | R. Darnell 4 | L. Patrick 7 |
| December 26, 2042 | WAKE FOREST DEMON DEACONS (3-7, 0-0, 2-3 Away)* | - | | | | |
| December 28, 2042 | BOSTON COLLEGE EAGLES (3-6, 0-0, 1-2 Away)* | - | | | | |
| January 2, 2043 | DUKE BLUE DEVILS (5-4, 0-0, 1-2 Away)* | - | | | | |
| January 4, 2043 | MIAMI (FL) HURRICANES (9-2, 0-0, 2-1 Away)* | - | | | | |
| January 9, 2043 | @ SMU Mustangs (6-4, 0-0, 5-2 Home)* | - | | | | |
| January 11, 2043 | VIRGINIA TECH HOKIES (4-6, 0-0, 0-2 Away)* | - | | | | |
| January 16, 2043 | @ Virginia Cavaliers (2-7, 0-0, 1-2 Home)* | - | | | | |
| January 18, 2043 | @ Florida State Seminoles (7-2, 0-0, 7-0 Home)* | - | | | | |
| January 23, 2043 | PITTSBURGH PANTHERS (7-4, 0-0, 0-3 Away)* | - | | | | |
| January 25, 2043 | STANFORD CARDINAL (11-1, 0-0, 1-1 Away)* | - | | | | |
| January 30, 2043 | @ Louisville Cardinals (9-2, 0-0, 4-1 Home)* | - | | | | |
| February 1, 2043 | CLEMSON TIGERS (2-7, 0-0, 1-3 Away)* | - | | | | |
| February 6, 2043 | @ NC State Wolfpack (6-3, 0-0, 6-0 Home)* | - | | | | |
| February 8, 2043 | @ Georgia Tech Yellow Jackets (8-3, 0-0, 3-1 Home)* | - | | | | |
| February 13, 2043 | @ Syracuse Orange (6-3, 0-0, 5-1 Home)* | - | | | | |
| February 15, 2043 | NOTRE DAME FIGHTING IRISH (8-4, 0-0, 0-3 Away)* | - | | | | |
| February 20, 2043 | @ North Carolina Tar Heels (10-1, 0-0, 5-0 Home)* | - | | | | |
| February 22, 2043 | GEORGIA TECH YELLOW JACKETS (8-3, 0-0, 2-2 Away)* | - | | | | |
| February 27, 2043 | @ Virginia Tech Hokies (4-6, 0-0, 3-3 Home)* | - | | | | |
| March 1, 2043 | @ Clemson Tigers (2-7, 0-0, 1-3 Home)* | - | | | | |
