| November 16, 2042 | GRAND CANYON ANTELOPES | W 84-72 | 1-0 | J. Brown 20 | R. Darnell 4 | L. Patrick 9 |
| November 19, 2042 | MOREHEAD STATE EAGLES | L 73-79 | 1-1 | L. Patrick 22 | R. Darnell 7 | L. Patrick 6 |
| November 23, 2042 | QUINNIPIAC BOBCATS | L 63-91 | 1-2 | L. Patrick 16 | R. Darnell 6 | J. Brown 7 |
| November 25, 2042 | @ Texas Longhorns | L 57-79 | 1-3 | W. Prescott 19 | R. Darnell 4 | L. Sawyer 9 |
| November 30, 2042 | @ Charleston Cougars | L 57-75 | 1-4 | J. Brown 16 | R. Darnell 2 | J. Brown 8 |
| December 7, 2042 | UNC ASHEVILLE BULLDOGS | L 90-97 OT | 1-5 | L. Patrick 23 | R. Darnell 9 | J. Brown 7 |
| December 13, 2042 | @ #19 Saint Mary's Gaels | L 68-87 | 1-6 | J. Brown 12 | R. Darnell 4 | W. Prescott 3 |
| December 21, 2042 | MANHATTAN JASPERS | L 83-92 | 1-7 | J. Brown 15 | R. Darnell 5 | J. Brown 5 |
| December 23, 2042 | UTSA ROADRUNNERS saatva Empire Classic | L 80-88 | 1-8 | W. Prescott 17 | R. Darnell 4 | L. Patrick 7 |
| December 26, 2042 | WAKE FOREST DEMON DEACONS* | W 88-66 | 2-8 | J. Brown 19 | R. Darnell 4 | W. Prescott 8 |
| December 28, 2042 | BOSTON COLLEGE EAGLES* | W 74-72 | 3-8 | J. Brown 17 | R. Darnell 5 | W. Prescott 9 |
| January 2, 2043 | DUKE BLUE DEVILS* | L 57-85 | 3-9 | L. Patrick 10 | R. Darnell 4 | J. Brown 10 |
| January 4, 2043 | #21 MIAMI (FL) HURRICANES* | W 76-74 OT | 4-9 | L. Patrick 25 | R. Darnell 7 | W. Prescott 9 |
| January 9, 2043 | @ SMU Mustangs* | L 59-85 | 4-10 | J. Brown 12 | R. Darnell 6 | L. Sawyer 5 |
| January 11, 2043 | VIRGINIA TECH HOKIES* | W 77-70 | 5-10 | L. Patrick 19 | R. Darnell 3 | J. Brown 11 |
| January 16, 2043 | @ Virginia Cavaliers* | L 73-80 | 5-11 | L. Patrick 17 | R. Darnell 6 | J. Brown 6 |
| January 18, 2043 | @ Florida State Seminoles* | L 56-74 | 5-12 | L. Patrick 17 | R. Darnell 4 | L. Sawyer 9 |
| January 23, 2043 | PITTSBURGH PANTHERS* | W 83-73 | 6-12 | L. Patrick 18 | R. Darnell 6 | J. Brown 8 |
| January 25, 2043 | #7 STANFORD CARDINAL* | L 80-104 | 6-13 | W. Prescott 21 | R. Darnell 4 | J. Brown 4 |
| January 30, 2043 | @ Louisville Cardinals* | L 94-106 | 6-14 | L. Patrick 21 | R. Darnell 7 | I. Ybarra 7 |
| February 1, 2043 | CLEMSON TIGERS* | W 78-68 | 7-14 | W. Prescott 16 | E. Dowling 3 | W. Prescott 8 |
| February 6, 2043 | @ NC State Wolfpack* | L 71-96 | 7-15 | J. Brown 29 | R. Darnell 4 | R. Darnell 5 |
| February 8, 2043 | @ Georgia Tech Yellow Jackets* | L 77-86 | 7-16 | L. Patrick 17 | R. Darnell 6 | I. Ybarra 8 |
| February 13, 2043 | @ Syracuse Orange (13-10, 7-7, 7-4 Home)* | - | | | | |
| February 15, 2043 | NOTRE DAME FIGHTING IRISH (19-7, 11-3, 5-6 Away)* | - | | | | |
| February 20, 2043 | @ North Carolina Tar Heels (24-1, 14-0, 12-0 Home)* | - | | | | |
| February 22, 2043 | GEORGIA TECH YELLOW JACKETS (16-9, 8-6, 4-6 Away)* | - | | | | |
| February 27, 2043 | @ Virginia Tech Hokies (4-20, 0-14, 3-9 Home)* | - | | | | |
| March 1, 2043 | @ Clemson Tigers (7-16, 5-9, 4-7 Home)* | - | | | | |
