| November 14, 2042 | @ Washington State Cougars | L 54-79 | 0-1 | L. Porter 9 | J. Randle 3 | A. Daniels 7 |
| November 23, 2042 | WINTHROP EAGLES | L 76-85 OT | 0-2 | J. Alvin 22 | J. Randle 5 | R. Griffin 9 |
| November 26, 2042 | @ Nebraska Cornhuskers | W 71-64 | 1-2 | J. Alvin 14 | J. Randle 6 | L. Porter 12 |
| November 30, 2042 | UC SAN DIEGO TRITONS | W 84-77 | 2-2 | L. Porter 16 | J. Alvin 5 | L. Porter 9 |
| December 6, 2042 | @ Akron Zips | L 77-102 | 2-3 | L. Porter 15 | J. Alvin 3 | J. Alvin 5 |
| December 13, 2042 | @ South Carolina Gamecocks | L 78-93 | 2-4 | A. Daniels 18 | J. Randle 5 | R. Griffin 7 |
| December 15, 2042 | #5 GONZAGA BULLDOGS | L 58-70 | 2-5 | L. Porter 14 | J. Randle 5 | L. Porter 9 |
| December 21, 2042 | HOWARD BISON | L 67-79 | 2-6 | J. Randle 16 | J. Randle 4 | L. Porter 11 |
| December 23, 2042 | @ BYU Cougars Gulf Coast Showcase | L 92-103 | 2-7 | C. Windlan 22 | J. Randle 8 | L. Porter 7 |
| December 26, 2042 | @ #5 North Carolina Tar Heels* | L 49-94 | 2-8 | R. Griffin 12 | M. Yearwood 3 | A. Daniels 9 |
| December 28, 2042 | SMU MUSTANGS* | W 87-77 | 3-8 | J. Randle 15 | G. Murphy 4 | A. Daniels 8 |
| January 2, 2043 | @ Syracuse Orange* | L 67-71 | 3-9 | J. Alvin 17 | J. Randle 8 | A. Daniels 8 |
| January 4, 2043 | BOSTON COLLEGE EAGLES* | W 92-66 | 4-9 | J. Alvin 16 | J. Randle 5 | L. Porter 14 |
| January 9, 2043 | @ Virginia Tech Hokies* | W 64-52 | 5-9 | A. Daniels 18 | J. Randle 7 | L. Porter 9 |
| January 11, 2043 | @ Wake Forest Demon Deacons* | W 73-62 | 6-9 | G. Murphy 15 | R. Griffin 3 | J. Randle 7 |
| January 16, 2043 | FLORIDA STATE SEMINOLES* | W 79-71 | 7-9 | R. Griffin 16 | A. Daniels 5 | R. Griffin 5 |
| January 18, 2043 | @ #7 Stanford Cardinal* | L 60-95 | 7-10 | R. Griffin 11 | D. Lawson 6 | R. Griffin 3 |
| January 23, 2043 | VIRGINIA CAVALIERS* | L 83-91 | 7-11 | R. Griffin 17 | D. Lawson 3 | R. Griffin 6 |
| January 25, 2043 | GEORGIA TECH YELLOW JACKETS* | L 83-84 | 7-12 | L. Porter 33 | D. Lawson 4 | R. Griffin 6 |
| January 30, 2043 | NC STATE WOLFPACK* | L 59-72 | 7-13 | J. Alvin 12 | D. Lawson 3 | A. Daniels 9 |
| February 1, 2043 | @ California Golden Bears* | L 68-78 | 7-14 | A. Daniels 17 | R. Griffin 4 | A. Daniels 10 |
| February 6, 2043 | @ Miami (FL) Hurricanes* | L 65-87 | 7-15 | J. Alvin 12 | J. Randle 6 | R. Griffin 9 |
| February 8, 2043 | PITTSBURGH PANTHERS* | L 78-92 | 7-16 | J. Alvin 14 | J. Randle 5 | A. Daniels 12 |
| February 13, 2043 | LOUISVILLE CARDINALS (15-10, 6-8, 4-5 Away)* | - | | | | |
| February 15, 2043 | @ Duke Blue Devils (13-10, 8-6, 8-3 Home)* | - | | | | |
| February 20, 2043 | @ Notre Dame Fighting Irish (19-7, 11-3, 10-1 Home)* | - | | | | |
| February 22, 2043 | NOTRE DAME FIGHTING IRISH (19-7, 11-3, 5-6 Away)* | - | | | | |
| February 27, 2043 | @ Georgia Tech Yellow Jackets (16-9, 8-6, 9-3 Home)* | - | | | | |
| March 1, 2043 | CALIFORNIA GOLDEN BEARS (7-16, 6-8, 0-9 Away)* | - | | | | |
