| November 14, 2042 | @ Washington State Cougars | L 54-79 | 0-1 | L. Porter 9 | J. Randle 3 | A. Daniels 7 |
| November 23, 2042 | WINTHROP EAGLES | L 76-85 OT | 0-2 | J. Alvin 22 | J. Randle 5 | R. Griffin 9 |
| November 26, 2042 | @ Nebraska Cornhuskers | W 71-64 | 1-2 | J. Alvin 14 | J. Randle 6 | L. Porter 12 |
| November 30, 2042 | UC SAN DIEGO TRITONS | W 84-77 | 2-2 | L. Porter 16 | J. Alvin 5 | L. Porter 9 |
| December 6, 2042 | @ Akron Zips | L 77-102 | 2-3 | L. Porter 15 | J. Alvin 3 | J. Alvin 5 |
| December 13, 2042 | @ South Carolina Gamecocks | L 78-93 | 2-4 | A. Daniels 18 | J. Randle 5 | R. Griffin 7 |
| December 15, 2042 | #5 GONZAGA BULLDOGS | L 58-70 | 2-5 | L. Porter 14 | J. Randle 5 | L. Porter 9 |
| December 21, 2042 | HOWARD BISON | L 67-79 | 2-6 | J. Randle 16 | J. Randle 4 | L. Porter 11 |
| December 23, 2042 | @ BYU Cougars Gulf Coast Showcase | L 92-103 | 2-7 | C. Windlan 22 | J. Randle 8 | L. Porter 7 |
| December 26, 2042 | @ North Carolina Tar Heels (10-1, 0-0, 5-0 Home)* | - | | | | |
| December 28, 2042 | SMU MUSTANGS (6-4, 0-0, 0-1 Away)* | - | | | | |
| January 2, 2043 | @ Syracuse Orange (6-3, 0-0, 5-1 Home)* | - | | | | |
| January 4, 2043 | BOSTON COLLEGE EAGLES (3-6, 0-0, 1-2 Away)* | - | | | | |
| January 9, 2043 | @ Virginia Tech Hokies (4-6, 0-0, 3-3 Home)* | - | | | | |
| January 11, 2043 | @ Wake Forest Demon Deacons (3-7, 0-0, 0-3 Home)* | - | | | | |
| January 16, 2043 | FLORIDA STATE SEMINOLES (7-2, 0-0, 0-2 Away)* | - | | | | |
| January 18, 2043 | @ Stanford Cardinal (11-1, 0-0, 6-0 Home)* | - | | | | |
| January 23, 2043 | VIRGINIA CAVALIERS (2-7, 0-0, 1-4 Away)* | - | | | | |
| January 25, 2043 | GEORGIA TECH YELLOW JACKETS (8-3, 0-0, 2-2 Away)* | - | | | | |
| January 30, 2043 | NC STATE WOLFPACK (6-3, 0-0, 0-2 Away)* | - | | | | |
| February 1, 2043 | @ California Golden Bears (1-8, 0-0, 1-4 Home)* | - | | | | |
| February 6, 2043 | @ Miami (FL) Hurricanes (9-2, 0-0, 5-0 Home)* | - | | | | |
| February 8, 2043 | PITTSBURGH PANTHERS (7-4, 0-0, 0-3 Away)* | - | | | | |
| February 13, 2043 | LOUISVILLE CARDINALS (9-2, 0-0, 3-0 Away)* | - | | | | |
| February 15, 2043 | @ Duke Blue Devils (5-4, 0-0, 4-1 Home)* | - | | | | |
| February 20, 2043 | @ Notre Dame Fighting Irish (8-4, 0-0, 4-1 Home)* | - | | | | |
| February 22, 2043 | NOTRE DAME FIGHTING IRISH (8-4, 0-0, 0-3 Away)* | - | | | | |
| February 27, 2043 | @ Georgia Tech Yellow Jackets (8-3, 0-0, 3-1 Home)* | - | | | | |
| March 1, 2043 | CALIFORNIA GOLDEN BEARS (1-8, 0-0, 0-3 Away)* | - | | | | |
