| November 14, 2042 | @ Kansas State Wildcats | L 51-68 | 0-1 | T. McNeil 18 | G. Lyle 5 | T. McNeil 9 |
| November 18, 2042 | NORTH TEXAS MEAN GREEN Emerald Coast Classic | W 84-73 | 1-1 | A. Brown 16 | G. Lyle 7 | T. McNeil 9 |
| November 19, 2042 | BELMONT BRUINS Emerald Coast Classic | W 77-61 | 2-1 | T. McNeil 16 | G. Lyle 6 | A. Brown 14 |
| November 20, 2042 | #17 GEORGIA TECH YELLOW JACKETS Emerald Coast Classic | L 74-81 | 2-2 | C. Bridge 17 | C. Bridge 4 | B. Ibarra 7 |
| November 22, 2042 | AUBURN TIGERS | W 55-39 | 3-2 | B. Ibarra 10 | M. Battier 2 | B. Ibarra 8 |
| December 3, 2042 | @ #8 Wichita State Shockers | L 77-85 | 3-3 | T. McNeil 13 | G. Lyle 5 | B. Ibarra 6 |
| December 10, 2042 | CLEVELAND STATE VIKINGS | L 54-59 | 3-4 | A. Bragg 10 | G. Lyle 6 | A. Brown 7 |
| December 13, 2042 | VIRGINIA CAVALIERS | W 79-65 | 4-4 | B. Ibarra 23 | G. Lyle 8 | T. McNeil 12 |
| December 16, 2042 | WINTHROP EAGLES | W 90-81 OT | 5-4 | T. McNeil 25 | G. Lyle 7 | T. McNeil 13 |
| December 20, 2042 | TEXAS LONGHORNS | W 80-57 | 6-4 | T. McNeil 21 | M. Woodward 6 | T. McNeil 13 |
| December 23, 2042 | @ #8 LSU Tigers | W 88-84 | 7-4 | T. McNeil 23 | G. Lyle 7 | T. McNeil 13 |
| December 26, 2042 | @ Seton Hall Pirates (8-1, 0-0, 8-0 Home)* | - | | | | |
| December 30, 2042 | GEORGETOWN HOYAS (2-8, 0-0, 0-6 Away)* | - | | | | |
| January 2, 2043 | @ Marquette Golden Eagles (5-4, 0-0, 4-2 Home)* | - | | | | |
| January 4, 2043 | @ Villanova Wildcats (5-4, 0-0, 4-2 Home)* | - | | | | |
| January 6, 2043 | ST. JOHN'S RED STORM (6-5, 0-0, 0-3 Away)* | - | | | | |
| January 11, 2043 | @ Providence Friars (4-5, 0-0, 3-2 Home)* | - | | | | |
| January 13, 2043 | @ Butler Bulldogs (6-4, 0-0, 4-1 Home)* | - | | | | |
| January 20, 2043 | CREIGHTON BLUE JAYS (9-2, 0-0, 3-1 Away)* | - | | | | |
| January 23, 2043 | VILLANOVA WILDCATS (5-4, 0-0, 1-1 Away)* | - | | | | |
| January 27, 2043 | DEPAUL BLUE DEMONS (3-7, 0-0, 0-1 Away)* | - | | | | |
| January 30, 2043 | XAVIER MUSKETEERS (8-2, 0-0, 1-1 Away)* | - | | | | |
| February 1, 2043 | @ St. John's Red Storm (6-5, 0-0, 4-1 Home)* | - | | | | |
| February 3, 2043 | @ Georgetown Hoyas (2-8, 0-0, 1-1 Home)* | - | | | | |
| February 8, 2043 | BUTLER BULLDOGS (6-4, 0-0, 1-2 Away)* | - | | | | |
| February 10, 2043 | PROVIDENCE FRIARS (4-5, 0-0, 1-2 Away)* | - | | | | |
| February 15, 2043 | @ DePaul Blue Demons (3-7, 0-0, 2-5 Home)* | - | | | | |
| February 17, 2043 | @ Xavier Musketeers (8-2, 0-0, 6-0 Home)* | - | | | | |
| February 22, 2043 | MARQUETTE GOLDEN EAGLES (5-4, 0-0, 1-1 Away)* | - | | | | |
| February 24, 2043 | SETON HALL PIRATES (8-1, 0-0, 0-1 Away)* | - | | | | |
| March 1, 2043 | @ Creighton Blue Jays (9-2, 0-0, 3-1 Home)* | - | | | | |
