| November 14, 2042 | @ Kansas State Wildcats | L 51-68 | 0-1 | T. McNeil 18 | G. Lyle 5 | T. McNeil 9 |
| November 18, 2042 | NORTH TEXAS MEAN GREEN Emerald Coast Classic | W 84-73 | 1-1 | A. Brown 16 | G. Lyle 7 | T. McNeil 9 |
| November 19, 2042 | BELMONT BRUINS Emerald Coast Classic | W 77-61 | 2-1 | T. McNeil 16 | G. Lyle 6 | A. Brown 14 |
| November 20, 2042 | #17 GEORGIA TECH YELLOW JACKETS Emerald Coast Classic | L 74-81 | 2-2 | C. Bridge 17 | C. Bridge 4 | B. Ibarra 7 |
| November 22, 2042 | AUBURN TIGERS | W 55-39 | 3-2 | B. Ibarra 10 | M. Battier 2 | B. Ibarra 8 |
| December 3, 2042 | @ #8 Wichita State Shockers | L 77-85 | 3-3 | T. McNeil 13 | G. Lyle 5 | B. Ibarra 6 |
| December 10, 2042 | CLEVELAND STATE VIKINGS | L 54-59 | 3-4 | A. Bragg 10 | G. Lyle 6 | A. Brown 7 |
| December 13, 2042 | VIRGINIA CAVALIERS | W 79-65 | 4-4 | B. Ibarra 23 | G. Lyle 8 | T. McNeil 12 |
| December 16, 2042 | WINTHROP EAGLES | W 90-81 OT | 5-4 | T. McNeil 25 | G. Lyle 7 | T. McNeil 13 |
| December 20, 2042 | TEXAS LONGHORNS | W 80-57 | 6-4 | T. McNeil 21 | M. Woodward 6 | T. McNeil 13 |
| December 23, 2042 | @ #8 LSU Tigers | W 88-84 | 7-4 | T. McNeil 23 | G. Lyle 7 | T. McNeil 13 |
| December 26, 2042 | @ Seton Hall Pirates* | L 66-89 | 7-5 | C. Bridge 18 | G. Lyle 4 | A. Brown 7 |
| December 30, 2042 | GEORGETOWN HOYAS* | W 77-70 | 8-5 | C. Bridge 23 | G. Lyle 7 | A. Brown 8 |
| January 2, 2043 | @ Marquette Golden Eagles* | W 88-80 | 9-5 | M. Battier 16 | T. McNeil 4 | O. Babic 6 |
| January 4, 2043 | @ Villanova Wildcats* | L 74-85 | 9-6 | C. Bridge 13 | G. Lyle 9 | A. Brown 9 |
| January 6, 2043 | ST. JOHN'S RED STORM* | W 90-67 | 10-6 | T. McNeil 25 | G. Lyle 4 | T. McNeil 14 |
| January 11, 2043 | @ Providence Friars* | W 94-89 OT | 11-6 | G. Lyle 25 | J. Mapp 5 | T. McNeil 14 |
| January 13, 2043 | @ #18 Butler Bulldogs* | L 77-93 | 11-7 | T. McNeil 18 | G. Lyle 7 | A. Brown 7 |
| January 20, 2043 | #22 CREIGHTON BLUE JAYS* | L 74-84 | 11-8 | T. McNeil 21 | G. Lyle 5 | T. McNeil 10 |
| January 23, 2043 | VILLANOVA WILDCATS* | W 89-79 | 12-8 | T. McNeil 18 | J. Mapp 5 | T. McNeil 7 |
| January 27, 2043 | DEPAUL BLUE DEMONS* | W 72-56 | 13-8 | B. Ibarra 21 | G. Lyle 6 | A. Brown 7 |
| January 30, 2043 | XAVIER MUSKETEERS* | W 85-74 | 14-8 | T. McNeil 20 | A. Brown 4 | A. Brown 11 |
| February 1, 2043 | @ St. John's Red Storm* | L 62-76 | 14-9 | T. McNeil 32 | G. Lyle 4 | T. McNeil 10 |
| February 3, 2043 | @ Georgetown Hoyas* | W 90-70 | 15-9 | T. McNeil 26 | G. Lyle 5 | A. Brown 10 |
| February 8, 2043 | #10 BUTLER BULLDOGS* | L 57-61 | 15-10 | A. Brown 16 | G. Lyle 4 | T. McNeil 16 |
| February 10, 2043 | PROVIDENCE FRIARS* | W 70-59 | 16-10 | C. Bridge 16 | G. Lyle 9 | T. McNeil 18 |
| February 15, 2043 | @ DePaul Blue Demons (10-13, 7-6, 6-7 Home)* | - | | | | |
| February 17, 2043 | @ Xavier Musketeers (13-11, 5-9, 9-3 Home)* | - | | | | |
| February 22, 2043 | MARQUETTE GOLDEN EAGLES (14-10, 9-6, 5-5 Away)* | - | | | | |
| February 24, 2043 | SETON HALL PIRATES (17-6, 9-5, 2-5 Away)* | - | | | | |
| March 1, 2043 | @ Creighton Blue Jays (17-8, 8-6, 6-4 Home)* | - | | | | |
