| November 16, 2042 | ARIZONA STATE SUN DEVILS | L 64-74 | 0-1 | M. Blizzard 21 | A. Joyner 3 | I. Villalobos 9 |
| November 18, 2042 | RICHMOND SPIDERS Allstate Maui Invitational | W 82-72 | 1-1 | R. Bolton 25 | A. Joyner 10 | M. Blizzard 10 |
| November 19, 2042 | SEATTLE REDHAWKS Allstate Maui Invitational | L 61-64 | 1-2 | C. Mobley 12 | A. Joyner 4 | I. Villalobos 8 |
| November 23, 2042 | NJIT HIGHLANDERS | W 96-75 | 2-2 | R. Bolton 27 | A. Joyner 8 | C. Shapiro 9 |
| November 26, 2042 | HOUSTON CHRISTIAN HUSKIES | W 98-75 | 3-2 | R. Bolton 28 | A. Joyner 6 | V. Roth 8 |
| November 30, 2042 | GRAND CANYON ANTELOPES | L 75-80 | 3-3 | A. Joyner 16 | C. Mobley 5 | V. Roth 7 |
| December 3, 2042 | ORAL ROBERTS GOLDEN EAGLES | L 38-53 | 3-4 | R. Bolton 8 | A. Joyner 3 | A. Joyner 7 |
| December 7, 2042 | MANHATTAN JASPERS | L 67-76 | 3-5 | V. Roth 15 | A. Joyner 5 | M. Blizzard 10 |
| December 13, 2042 | @ Loyola Chicago Ramblers | L 72-77 | 3-6 | R. Bolton 14 | A. Joyner 8 | A. Joyner 7 |
| December 21, 2042 | BOSTON UNIVERSITY TERRIERS | L 73-74 | 3-7 | V. Roth 16 | A. Joyner 7 | V. Roth 8 |
| December 26, 2042 | @ Georgetown Hoyas* | W 65-64 | 4-7 | M. Blizzard 16 | A. Joyner 5 | M. Blizzard 13 |
| December 28, 2042 | #17 CREIGHTON BLUE JAYS* | W 85-78 | 5-7 | R. Bolton 20 | V. Roth 4 | M. Blizzard 9 |
| January 2, 2043 | @ St. John's Red Storm* | W 96-91 | 6-7 | M. Blizzard 28 | R. Bolton 6 | M. Blizzard 9 |
| January 4, 2043 | #25 SETON HALL PIRATES* | W 81-68 | 7-7 | M. Blizzard 25 | A. Joyner 3 | V. Roth 12 |
| January 11, 2043 | XAVIER MUSKETEERS* | L 74-80 OT | 7-8 | R. Bolton 24 | A. Joyner 3 | M. Blizzard 10 |
| January 13, 2043 | @ Marquette Golden Eagles* | L 78-93 | 7-9 | A. Joyner 24 | A. Joyner 8 | C. Shapiro 5 |
| January 20, 2043 | #13 BUTLER BULLDOGS* | L 59-72 | 7-10 | R. Bolton 13 | R. Bolton 5 | V. Roth 9 |
| January 23, 2043 | PROVIDENCE FRIARS* | W 76-73 | 8-10 | I. Villalobos 13 | A. Joyner 4 | M. Blizzard 12 |
| January 27, 2043 | @ Connecticut Huskies* | L 56-72 | 8-11 | C. Mobley 13 | R. Bolton 6 | C. Shapiro 9 |
| January 30, 2043 | @ Villanova Wildcats* | W 75-72 | 9-11 | R. Bolton 14 | R. Bolton 6 | K. Newman 9 |
| February 1, 2043 | @ #21 Seton Hall Pirates* | L 54-73 | 9-12 | I. Villalobos 23 | C. Mobley 4 | M. Blizzard 11 |
| February 3, 2043 | MARQUETTE GOLDEN EAGLES* | W 72-66 | 10-12 | I. Villalobos 21 | C. Mobley 5 | C. Shapiro 6 |
| February 8, 2043 | @ Xavier Musketeers* | L 72-85 | 10-13 | J. Shields 12 | I. Villalobos 4 | J. Shields 5 |
| February 13, 2043 | @ #23 Creighton Blue Jays* | L 65-87 | 10-14 | I. Villalobos 21 | A. Joyner 4 | I. Villalobos 7 |
| February 15, 2043 | CONNECTICUT HUSKIES* | W 72-62 | 11-14 | K. Newman 13 | I. Villalobos 7 | K. Newman 9 |
| February 17, 2043 | VILLANOVA WILDCATS* | W 88-85 | 12-14 | A. Joyner 21 | R. Bolton 4 | K. Newman 7 |
| February 22, 2043 | @ #6 Butler Bulldogs* | L 71-89 | 12-15 | I. Villalobos 19 | A. Joyner 5 | M. Blizzard 7 |
| February 24, 2043 | @ Providence Friars* | L 72-84 | 12-16 | A. Joyner 23 | I. Villalobos 4 | C. Shapiro 6 |
| March 1, 2043 | GEORGETOWN HOYAS* | L 61-68 | 12-17 | M. Blizzard 14 | R. Bolton 5 | M. Blizzard 10 |
| March 3, 2043 | ST. JOHN'S RED STORM* | W 82-62 | 13-17 | M. Blizzard 19 | I. Villalobos 4 | C. Shapiro 11 |
| March 9, 2043 | PROVIDENCE FRIARS Big East Tournament | W 81-55 | 14-17 | A. Joyner 23 | A. Joyner 4 | R. Bolton 10 |
| March 10, 2043 | @ Seton Hall Pirates Big East Tournament | L 85-87 | 14-18 | M. Blizzard 17 | A. Joyner 6 | J. Shields 5 |
