| November 15, 2042 | IU INDY JAGUARS | L 68-79 | 0-1 | D. Britton 23 | D. Britton 4 | D. Britton 5 |
| November 25, 2042 | NEW HAMPSHIRE WILDCATS | L 72-87 | 0-2 | Z. Shields 16 | J. Xavier 5 | A. Cable 16 |
| November 28, 2042 | LIPSCOMB BISONS | L 75-82 | 0-3 | A. Cable 15 | D. Britton 4 | A. Cable 8 |
| December 2, 2042 | @ Chicago State Cougars | L 69-74 | 0-4 | J. Xavier 17 | D. Britton 7 | E. Jamison 9 |
| December 5, 2042 | @ TCU Horned Frogs | L 72-86 | 0-5 | Z. Shields 20 | D. Britton 6 | E. Jamison 10 |
| December 9, 2042 | @ Oklahoma Sooners Cayman Islands Classic | L 60-85 | 0-6 | Z. Shields 13 | D. Britton 2 | Z. Shields 7 |
| December 13, 2042 | OMAHA MAVERICKS | L 66-79 | 0-7 | D. Britton 19 | D. Britton 3 | E. Jamison 4 |
| December 19, 2042 | @ South Carolina State Bulldogs | L 70-82 | 0-8 | Z. Shields 10 | A. Cable 4 | A. Cable 8 |
| December 24, 2042 | PRINCETON TIGERS | L 71-98 | 0-9 | Z. Shields 14 | D. Britton 4 | A. Cable 9 |
| December 26, 2042 | ILLINOIS STATE REDBIRDS* | W 83-80 OT | 1-9 | I. Stuart 20 | E. Jamison 7 | A. Cable 11 |
| December 29, 2042 | BELMONT BRUINS* | L 67-88 | 1-10 | Z. Shields 15 | A. Cable 4 | A. Cable 7 |
| January 2, 2043 | @ Southern Illinois Salukis* | L 61-80 | 1-11 | J. Xavier 13 | E. Jamison 4 | A. Cable 17 |
| January 5, 2043 | @ Bradley Braves* | L 80-84 OT | 1-12 | L. Forrest 11 | J. Xavier 4 | L. Forrest 6 |
| January 9, 2043 | @ Indiana State Sycamores* | L 72-94 | 1-13 | K. Blair 13 | D. Britton 7 | I. Stuart 10 |
| January 12, 2043 | NORTHERN IOWA PANTHERS* | W 72-65 | 2-13 | Z. Shields 13 | E. Jamison 5 | A. Cable 11 |
| January 16, 2043 | UIC FLAMES* | W 68-54 | 3-13 | Z. Shields 14 | J. Xavier 4 | W. Clark 6 |
| January 19, 2043 | @ Valparaiso Crusaders* | L 66-92 | 3-14 | I. Stuart 16 | D. Britton 7 | I. Stuart 6 |
| January 23, 2043 | @ Murray State Racers* | L 63-82 | 3-15 | A. Cable 14 | D. Britton 3 | Z. Shields 8 |
| January 26, 2043 | EVANSVILLE PURPLE ACES* | L 86-91 OT | 3-16 | A. Cable 22 | E. Jamison 5 | A. Cable 8 |
| January 30, 2043 | VALPARAISO CRUSADERS* | W 108-75 | 4-16 | B. Boschee 19 | B. Boschee 6 | A. Cable 9 |
| February 2, 2043 | MURRAY STATE RACERS* | L 77-84 | 4-17 | Z. Shields 17 | I. Stuart 4 | A. Cable 9 |
| February 6, 2043 | @ Northern Iowa Panthers* | W 69-64 | 5-17 | Z. Shields 15 | E. Jamison 4 | Z. Shields 12 |
| February 9, 2043 | @ UIC Flames* | W 82-61 | 6-17 | K. Blair 17 | I. Stuart 3 | I. Stuart 6 |
| February 13, 2043 | SOUTHERN ILLINOIS SALUKIS* | W 75-70 | 7-17 | D. Britton 17 | D. Britton 4 | A. Cable 13 |
| February 16, 2043 | BRADLEY BRAVES* | L 73-79 | 7-18 | Z. Shields 18 | D. Britton 3 | E. Jamison 5 |
| February 20, 2043 | @ Illinois State Redbirds* | L 67-76 | 7-19 | Z. Shields 18 | J. Xavier 5 | Z. Shields 13 |
| February 23, 2043 | @ Belmont Bruins* | L 68-77 | 7-20 | D. Britton 15 | E. Jamison 3 | E. Jamison 9 |
| February 27, 2043 | @ Evansville Purple Aces* | L 69-85 | 7-21 | I. Stuart 15 | D. Britton 6 | A. Cable 6 |
| March 2, 2043 | MISSOURI STATE BEARS* | L 77-81 | 7-22 | E. Jamison 17 | D. Britton 4 | A. Cable 9 |
| March 6, 2043 | @ Missouri State Bears MVC Tournament | L 72-74 | 7-23 | Z. Shields 15 | D. Britton 7 | Z. Shields 9 |
