| November 16, 2042 | @ Monmouth Hawks | L 91-97 | 0-1 | A. Houston 15 | A. Houston 4 | S. Holguin 8 |
| November 18, 2042 | TENNESSEE TECH GOLDEN EAGLES | W 65-57 | 1-1 | C. Gilbert 13 | B. Dawson 4 | C. Gilbert 8 |
| November 23, 2042 | @ Butler Bulldogs | L 67-84 | 1-2 | D. Hedrick 15 | A. Minor 5 | C. Gilbert 7 |
| November 26, 2042 | @ Princeton Tigers | W 84-76 | 2-2 | S. Holguin 26 | B. Phillips 3 | S. Holguin 9 |
| November 29, 2042 | @ VCU Rams | L 60-82 | 2-3 | B. Phillips 11 | A. Houston 5 | S. Holguin 8 |
| December 1, 2042 | LAMAR CARDINALS | W 73-65 | 3-3 | D. Hedrick 17 | A. Houston 6 | C. Gilbert 6 |
| December 6, 2042 | MOREHEAD STATE EAGLES | W 75-65 | 4-3 | A. Houston 16 | B. Phillips 5 | D. Hedrick 6 |
| December 13, 2042 | UNC WILMINGTON SEAHAWKS | W 85-81 | 5-3 | B. Phillips 23 | A. Houston 6 | S. Holguin 12 |
| December 16, 2042 | @ #16 Maryland Terrapins Diamond Head Classic | L 66-79 | 5-4 | S. Holguin 23 | D. Hedrick 3 | S. Holguin 13 |
| December 19, 2042 | @ #18 Oklahoma State Cowboys | L 57-64 | 5-5 | B. Phillips 12 | A. Houston 7 | C. Gilbert 10 |
| December 26, 2042 | FDU KNIGHTS | L 75-77 | 5-6 | B. Dawson 15 | A. Houston 6 | D. Hedrick 7 |
| January 2, 2043 | @ #5 Wichita State Shockers* | L 63-87 | 5-7 | S. Holguin 20 | D. Hedrick 3 | D. Hedrick 6 |
| January 9, 2043 | @ South Florida Bulls* | L 74-88 | 5-8 | D. Hedrick 15 | A. Houston 3 | D. Hedrick 5 |
| January 12, 2043 | UAB BLAZERS* | L 72-77 | 5-9 | D. Hedrick 12 | S. Holguin 4 | B. Phillips 6 |
| January 14, 2043 | @ UTSA Roadrunners* | W 82-59 | 6-9 | C. Gilbert 19 | A. Houston 6 | D. Hedrick 10 |
| January 16, 2043 | @ Charlotte 49ers* | L 57-72 | 6-10 | A. Houston 11 | A. Houston 6 | D. Thompson 8 |
| January 19, 2043 | NORTH TEXAS MEAN GREEN* | W 90-71 | 7-10 | S. Holguin 25 | B. Phillips 6 | C. Gilbert 9 |
| January 23, 2043 | UTSA ROADRUNNERS* | W 83-76 | 8-10 | C. Gilbert 24 | A. Houston 4 | D. Hedrick 9 |
| January 26, 2043 | @ Temple Owls* | L 73-83 | 8-11 | A. Houston 15 | A. Houston 5 | S. Holguin 8 |
| January 28, 2043 | @ North Texas Mean Green* | W 95-83 | 9-11 | S. Holguin 16 | A. Minor 8 | C. Gilbert 12 |
| January 30, 2043 | TULSA GOLDEN HURRICANES* | W 87-85 | 10-11 | S. Holguin 21 | B. Phillips 6 | C. Gilbert 8 |
| February 2, 2043 | @ Tulane Green Wave* | L 74-92 | 10-12 | C. Gilbert 16 | S. Holguin 4 | D. Hedrick 7 |
| February 6, 2043 | @ UAB Blazers* | L 80-91 | 10-13 | C. Gilbert 16 | A. Houston 3 | C. Gilbert 6 |
| February 9, 2043 | FLORIDA ATLANTIC OWLS* | L 78-82 | 10-14 | S. Holguin 15 | A. Houston 5 | R. Newberry 6 |
| February 13, 2043 | RICE OWLS* | W 92-63 | 11-14 | S. Holguin 16 | A. Houston 5 | S. Holguin 8 |
| February 16, 2043 | @ Memphis Tigers* | L 68-83 | 11-15 | S. Holguin 16 | A. Houston 2 | D. Hedrick 7 |
| February 20, 2043 | WICHITA STATE SHOCKERS (25-3, 14-1, 8-2 Away)* | - | | | | |
| February 27, 2043 | SOUTH FLORIDA BULLS (21-5, 11-3, 5-2 Away)* | - | | | | |
| March 2, 2043 | CHARLOTTE 49ERS (19-9, 10-4, 6-7 Away)* | - | | | | |
