| November 16, 2042 | CHICAGO STATE COUGARS | W 91-72 | 1-0 | N. Fonseca 25 | D. Toole 8 | J. Humphries 8 |
| November 18, 2042 | STONY BROOK SEAWOLVES Emerald Coast Classic | W 96-68 | 2-0 | J. Humphries 16 | D. Toole 3 | J. Albert 8 |
| November 19, 2042 | WINTHROP EAGLES Emerald Coast Classic | W 97-90 | 3-0 | N. Fonseca 26 | D. Toole 6 | B. McCarthy 7 |
| November 20, 2042 | @ #23 Connecticut Huskies Emerald Coast Classic | W 81-74 | 4-0 | N. Fonseca 23 | D. Toole 6 | A. Adams 12 |
| November 23, 2042 | @ Georgetown Hoyas | L 62-75 | 4-1 | B. McCarthy 14 | D. Toole 4 | J. Albert 15 |
| November 24, 2042 | @ Kansas State Wildcats | W 69-59 | 5-1 | N. Fonseca 24 | J. Reynolds 4 | J. Humphries 9 |
| November 29, 2042 | UMASS LOWELL RIVER HAWKS | W 76-68 | 6-1 | N. Fonseca 23 | D. Toole 3 | J. Albert 10 |
| December 1, 2042 | FDU KNIGHTS | L 70-87 | 6-2 | A. Adams 19 | N. Fonseca 4 | A. Adams 7 |
| December 5, 2042 | @ #2 Baylor Bears | L 74-88 | 6-3 | N. Fonseca 16 | D. Toole 3 | J. Humphries 7 |
| December 13, 2042 | @ Georgia Bulldogs | W 78-66 | 7-3 | N. Fonseca 16 | N. Fonseca 4 | J. Humphries 8 |
| December 21, 2042 | GREEN BAY PHOENIX | W 65-60 | 8-3 | N. Fonseca 28 | D. Toole 4 | J. Albert 5 |
| December 26, 2042 | VIRGINIA TECH HOKIES* | W 79-69 | 9-3 | D. Toole 12 | D. Toole 3 | N. Fonseca 7 |
| December 28, 2042 | @ #18 Miami (FL) Hurricanes* | L 67-82 | 9-4 | D. Toole 15 | B. McCarthy 2 | N. Fonseca 6 |
| January 2, 2043 | #14 NOTRE DAME FIGHTING IRISH* | L 81-104 | 9-5 | N. Fonseca 21 | D. Toole 3 | J. Humphries 6 |
| January 4, 2043 | SYRACUSE ORANGE* | W 79-77 | 10-5 | J. Albert 19 | D. Toole 5 | J. Albert 8 |
| January 9, 2043 | @ Boston College Eagles* | L 77-79 | 10-6 | J. Humphries 15 | D. Toole 6 | J. Humphries 10 |
| January 11, 2043 | @ SMU Mustangs* | W 76-74 | 11-6 | N. Fonseca 14 | J. Reynolds 6 | J. Humphries 6 |
| January 16, 2043 | PITTSBURGH PANTHERS* | L 66-71 | 11-7 | B. McCarthy 17 | D. Toole 8 | J. Humphries 10 |
| January 18, 2043 | @ Duke Blue Devils* | L 58-65 | 11-8 | N. Fonseca 14 | D. Toole 6 | J. Albert 9 |
| January 23, 2043 | FLORIDA STATE SEMINOLES* | W 84-75 | 12-8 | N. Fonseca 31 | D. Toole 8 | A. Adams 8 |
| January 25, 2043 | @ Clemson Tigers* | W 84-83 | 13-8 | N. Fonseca 17 | A. Adams 4 | J. Humphries 6 |
| January 30, 2043 | VIRGINIA CAVALIERS* | W 74-67 | 14-8 | N. Fonseca 17 | N. Fonseca 3 | J. Albert 7 |
| February 1, 2043 | #8 STANFORD CARDINAL* | W 83-73 | 15-8 | N. Fonseca 19 | D. Toole 6 | B. McCarthy 5 |
| February 6, 2043 | @ Louisville Cardinals* | L 61-82 | 15-9 | N. Fonseca 13 | D. Toole 4 | J. Humphries 8 |
| February 8, 2043 | CALIFORNIA GOLDEN BEARS* | W 86-77 | 16-9 | A. Adams 19 | D. Toole 8 | B. McCarthy 7 |
| February 13, 2043 | @ NC State Wolfpack (15-8, 9-5, 12-2 Home)* | - | | | | |
| February 15, 2043 | NORTH CAROLINA TAR HEELS (24-1, 14-0, 9-1 Away)* | - | | | | |
| February 20, 2043 | @ Wake Forest Demon Deacons (6-18, 3-11, 3-8 Home)* | - | | | | |
| February 22, 2043 | @ California Golden Bears (7-16, 6-8, 7-6 Home)* | - | | | | |
| February 27, 2043 | CLEMSON TIGERS (7-16, 5-9, 3-8 Away)* | - | | | | |
| March 1, 2043 | @ Notre Dame Fighting Irish (19-7, 11-3, 10-1 Home)* | - | | | | |
