| November 16, 2042 | CHICAGO STATE COUGARS | W 91-72 | 1-0 | N. Fonseca 25 | D. Toole 8 | J. Humphries 8 |
| November 18, 2042 | STONY BROOK SEAWOLVES Emerald Coast Classic | W 96-68 | 2-0 | J. Humphries 16 | D. Toole 3 | J. Albert 8 |
| November 19, 2042 | WINTHROP EAGLES Emerald Coast Classic | W 97-90 | 3-0 | N. Fonseca 26 | D. Toole 6 | B. McCarthy 7 |
| November 20, 2042 | @ #23 Connecticut Huskies Emerald Coast Classic | W 81-74 | 4-0 | N. Fonseca 23 | D. Toole 6 | A. Adams 12 |
| November 23, 2042 | @ Georgetown Hoyas | L 62-75 | 4-1 | B. McCarthy 14 | D. Toole 4 | J. Albert 15 |
| November 24, 2042 | @ Kansas State Wildcats | W 69-59 | 5-1 | N. Fonseca 24 | J. Reynolds 4 | J. Humphries 9 |
| November 29, 2042 | UMASS LOWELL RIVER HAWKS | W 76-68 | 6-1 | N. Fonseca 23 | D. Toole 3 | J. Albert 10 |
| December 1, 2042 | FDU KNIGHTS | L 70-87 | 6-2 | A. Adams 19 | N. Fonseca 4 | A. Adams 7 |
| December 5, 2042 | @ #2 Baylor Bears | L 74-88 | 6-3 | N. Fonseca 16 | D. Toole 3 | J. Humphries 7 |
| December 13, 2042 | @ Georgia Bulldogs | W 78-66 | 7-3 | N. Fonseca 16 | N. Fonseca 4 | J. Humphries 8 |
| December 21, 2042 | GREEN BAY PHOENIX | W 65-60 | 8-3 | N. Fonseca 28 | D. Toole 4 | J. Albert 5 |
| December 26, 2042 | VIRGINIA TECH HOKIES (4-6, 0-0, 0-2 Away)* | - | | | | |
| December 28, 2042 | @ Miami (FL) Hurricanes (9-2, 0-0, 5-0 Home)* | - | | | | |
| January 2, 2043 | NOTRE DAME FIGHTING IRISH (8-4, 0-0, 0-3 Away)* | - | | | | |
| January 4, 2043 | SYRACUSE ORANGE (6-3, 0-0, 1-1 Away)* | - | | | | |
| January 9, 2043 | @ Boston College Eagles (3-6, 0-0, 2-3 Home)* | - | | | | |
| January 11, 2043 | @ SMU Mustangs (6-4, 0-0, 5-2 Home)* | - | | | | |
| January 16, 2043 | PITTSBURGH PANTHERS (7-4, 0-0, 0-3 Away)* | - | | | | |
| January 18, 2043 | @ Duke Blue Devils (5-4, 0-0, 4-1 Home)* | - | | | | |
| January 23, 2043 | FLORIDA STATE SEMINOLES (7-2, 0-0, 0-2 Away)* | - | | | | |
| January 25, 2043 | @ Clemson Tigers (2-7, 0-0, 1-3 Home)* | - | | | | |
| January 30, 2043 | VIRGINIA CAVALIERS (2-7, 0-0, 1-4 Away)* | - | | | | |
| February 1, 2043 | STANFORD CARDINAL (11-1, 0-0, 1-1 Away)* | - | | | | |
| February 6, 2043 | @ Louisville Cardinals (9-2, 0-0, 4-1 Home)* | - | | | | |
| February 8, 2043 | CALIFORNIA GOLDEN BEARS (1-8, 0-0, 0-3 Away)* | - | | | | |
| February 13, 2043 | @ NC State Wolfpack (6-3, 0-0, 6-0 Home)* | - | | | | |
| February 15, 2043 | NORTH CAROLINA TAR HEELS (10-1, 0-0, 2-1 Away)* | - | | | | |
| February 20, 2043 | @ Wake Forest Demon Deacons (3-7, 0-0, 0-3 Home)* | - | | | | |
| February 22, 2043 | @ California Golden Bears (1-8, 0-0, 1-4 Home)* | - | | | | |
| February 27, 2043 | CLEMSON TIGERS (2-7, 0-0, 1-3 Away)* | - | | | | |
| March 1, 2043 | @ Notre Dame Fighting Irish (8-4, 0-0, 4-1 Home)* | - | | | | |
