| November 13, 2042 | GARDNER-WEBB RUNNIN' BULLDOGS Legends Classic | W 86-63 | 1-0 | R. Largent 17 | C. Munoz 5 | R. Largent 15 |
| November 15, 2042 | CHARLESTON COUGARS Legends Classic | L 73-76 | 1-1 | R. Largent 20 | C. Munoz 6 | L. Barrera 5 |
| November 23, 2042 | #17 GEORGIA TECH YELLOW JACKETS | W 75-62 | 2-1 | R. Weaver 13 | C. Munoz 3 | R. Largent 11 |
| November 26, 2042 | @ Nevada Wolfpack | L 70-92 | 2-2 | R. Largent 18 | C. Munoz 8 | R. Largent 13 |
| November 30, 2042 | @ Arizona State Sun Devils | L 75-83 | 2-3 | L. Barrera 17 | C. Munoz 6 | R. Largent 8 |
| December 3, 2042 | @ BYU Cougars | L 64-84 | 2-4 | A. Armstrong 20 | C. Munoz 4 | R. Largent 11 |
| December 7, 2042 | @ Memphis Tigers | L 63-72 | 2-5 | A. Armstrong 13 | L. Barrera 4 | R. Weaver 10 |
| December 10, 2042 | @ USC Trojans | L 87-96 OT | 2-6 | R. Largent 24 | L. Barrera 6 | A. Armstrong 9 |
| December 13, 2042 | SYRACUSE ORANGE | L 80-93 | 2-7 | C. Munoz 18 | L. Barrera 4 | R. Largent 11 |
| December 21, 2042 | @ Arkansas Razorbacks | L 73-76 OT | 2-8 | C. Munoz 20 | C. Munoz 3 | R. Weaver 10 |
| December 26, 2042 | DEPAUL BLUE DEMONS (3-7, 0-0, 0-1 Away)* | - | | | | |
| December 30, 2042 | @ Connecticut Huskies (7-4, 0-0, 4-1 Home)* | - | | | | |
| January 2, 2043 | XAVIER MUSKETEERS (8-2, 0-0, 1-1 Away)* | - | | | | |
| January 4, 2043 | BUTLER BULLDOGS (6-4, 0-0, 1-2 Away)* | - | | | | |
| January 6, 2043 | @ Villanova Wildcats (5-4, 0-0, 4-2 Home)* | - | | | | |
| January 11, 2043 | @ St. John's Red Storm (6-5, 0-0, 4-1 Home)* | - | | | | |
| January 16, 2043 | @ Creighton Blue Jays (9-2, 0-0, 3-1 Home)* | - | | | | |
| January 18, 2043 | SETON HALL PIRATES (8-1, 0-0, 0-1 Away)* | - | | | | |
| January 20, 2043 | MARQUETTE GOLDEN EAGLES (5-4, 0-0, 1-1 Away)* | - | | | | |
| January 25, 2043 | @ Providence Friars (4-5, 0-0, 3-2 Home)* | - | | | | |
| January 27, 2043 | @ Butler Bulldogs (6-4, 0-0, 4-1 Home)* | - | | | | |
| February 1, 2043 | VILLANOVA WILDCATS (5-4, 0-0, 1-1 Away)* | - | | | | |
| February 3, 2043 | CONNECTICUT HUSKIES (7-4, 0-0, 1-2 Away)* | - | | | | |
| February 8, 2043 | @ Marquette Golden Eagles (5-4, 0-0, 4-2 Home)* | - | | | | |
| February 10, 2043 | @ Seton Hall Pirates (8-1, 0-0, 8-0 Home)* | - | | | | |
| February 17, 2043 | PROVIDENCE FRIARS (4-5, 0-0, 1-2 Away)* | - | | | | |
| February 24, 2043 | CREIGHTON BLUE JAYS (9-2, 0-0, 3-1 Away)* | - | | | | |
| February 27, 2043 | ST. JOHN'S RED STORM (6-5, 0-0, 0-3 Away)* | - | | | | |
| March 1, 2043 | @ DePaul Blue Demons (3-7, 0-0, 2-5 Home)* | - | | | | |
| March 3, 2043 | @ Xavier Musketeers (8-2, 0-0, 6-0 Home)* | - | | | | |
