| November 13, 2042 | GARDNER-WEBB RUNNIN' BULLDOGS Legends Classic | W 86-63 | 1-0 | R. Largent 17 | C. Munoz 5 | R. Largent 15 |
| November 15, 2042 | CHARLESTON COUGARS Legends Classic | L 73-76 | 1-1 | R. Largent 20 | C. Munoz 6 | L. Barrera 5 |
| November 23, 2042 | #17 GEORGIA TECH YELLOW JACKETS | W 75-62 | 2-1 | R. Weaver 13 | C. Munoz 3 | R. Largent 11 |
| November 26, 2042 | @ Nevada Wolfpack | L 70-92 | 2-2 | R. Largent 18 | C. Munoz 8 | R. Largent 13 |
| November 30, 2042 | @ Arizona State Sun Devils | L 75-83 | 2-3 | L. Barrera 17 | C. Munoz 6 | R. Largent 8 |
| December 3, 2042 | @ BYU Cougars | L 64-84 | 2-4 | A. Armstrong 20 | C. Munoz 4 | R. Largent 11 |
| December 7, 2042 | @ Memphis Tigers | L 63-72 | 2-5 | A. Armstrong 13 | L. Barrera 4 | R. Weaver 10 |
| December 10, 2042 | @ USC Trojans | L 87-96 OT | 2-6 | R. Largent 24 | L. Barrera 6 | A. Armstrong 9 |
| December 13, 2042 | SYRACUSE ORANGE | L 80-93 | 2-7 | C. Munoz 18 | L. Barrera 4 | R. Largent 11 |
| December 21, 2042 | @ Arkansas Razorbacks | L 73-76 OT | 2-8 | C. Munoz 20 | C. Munoz 3 | R. Weaver 10 |
| December 26, 2042 | DEPAUL BLUE DEMONS* | L 64-65 | 2-9 | A. Armstrong 18 | C. Munoz 2 | R. Largent 10 |
| December 30, 2042 | @ Connecticut Huskies* | L 70-77 | 2-10 | R. Largent 15 | C. Munoz 5 | A. Armstrong 11 |
| January 2, 2043 | XAVIER MUSKETEERS* | W 77-69 | 3-10 | C. Munoz 14 | C. Munoz 4 | R. Weaver 12 |
| January 4, 2043 | #20 BUTLER BULLDOGS* | L 63-75 | 3-11 | L. Barrera 14 | C. Munoz 4 | R. Largent 10 |
| January 6, 2043 | @ Villanova Wildcats* | W 80-68 | 4-11 | C. Munoz 23 | C. Munoz 5 | R. Weaver 10 |
| January 11, 2043 | @ St. John's Red Storm* | W 79-72 | 5-11 | L. Barrera 16 | D. Allen 4 | R. Weaver 11 |
| January 16, 2043 | @ #22 Creighton Blue Jays* | L 59-82 | 5-12 | L. Barrera 17 | C. Munoz 7 | L. Barrera 6 |
| January 18, 2043 | #20 SETON HALL PIRATES* | W 78-69 | 6-12 | A. Armstrong 18 | C. Munoz 5 | R. Largent 12 |
| January 20, 2043 | MARQUETTE GOLDEN EAGLES* | L 71-81 | 6-13 | A. Armstrong 16 | C. Munoz 8 | R. Largent 10 |
| January 25, 2043 | @ Providence Friars* | L 79-82 | 6-14 | L. Barrera 23 | C. Munoz 6 | R. Largent 10 |
| January 27, 2043 | @ #12 Butler Bulldogs* | L 63-86 | 6-15 | C. Munoz 10 | C. Munoz 3 | R. Largent 7 |
| February 1, 2043 | VILLANOVA WILDCATS* | W 97-86 | 7-15 | R. Largent 21 | R. Krieger 6 | R. Largent 8 |
| February 3, 2043 | CONNECTICUT HUSKIES* | L 70-90 | 7-16 | A. Armstrong 13 | C. Munoz 4 | R. Moore 6 |
| February 8, 2043 | @ Marquette Golden Eagles* | L 70-76 | 7-17 | A. Armstrong 21 | C. Munoz 6 | R. Largent 11 |
| February 10, 2043 | @ #23 Seton Hall Pirates* | W 80-79 | 8-17 | L. Barrera 17 | C. Munoz 6 | A. Armstrong 12 |
| February 17, 2043 | PROVIDENCE FRIARS (9-14, 5-9, 3-6 Away)* | - | | | | |
| February 24, 2043 | CREIGHTON BLUE JAYS (17-8, 8-6, 8-4 Away)* | - | | | | |
| February 27, 2043 | ST. JOHN'S RED STORM (9-17, 3-12, 0-10 Away)* | - | | | | |
| March 1, 2043 | @ DePaul Blue Demons (10-13, 7-6, 6-7 Home)* | - | | | | |
| March 3, 2043 | @ Xavier Musketeers (13-11, 5-9, 9-3 Home)* | - | | | | |
