| November 18, 2042 | WINTHROP EAGLES Emerald Coast Classic | L 88-89 | 0-1 | J. Tolbert 24 | S. Leary 5 | G. Roland 9 |
| November 22, 2042 | BINGHAMTON BEARCATS | L 76-83 | 0-2 | R. Miner 13 | S. Leary 5 | R. Miner 9 |
| November 26, 2042 | MICHIGAN WOLVERINES | W 88-72 | 1-2 | R. Miner 16 | S. Leary 3 | R. Miner 11 |
| December 3, 2042 | #3 STANFORD CARDINAL | L 80-86 | 1-3 | J. Tolbert 19 | S. Leary 3 | R. Miner 6 |
| December 6, 2042 | ALABAMA CRIMSON TIDE | L 90-92 | 1-4 | K. Akers 21 | S. Leary 5 | K. Akers 5 |
| December 10, 2042 | @ #3 Minnesota Golden Gophers | L 62-79 | 1-5 | S. Leary 11 | S. Leary 9 | R. Miner 8 |
| December 13, 2042 | IOWA HAWKEYES | L 75-88 | 1-6 | J. Tolbert 15 | M. Evans 6 | K. Akers 7 |
| December 16, 2042 | @ South Carolina Gamecocks | L 76-81 | 1-7 | J. Tolbert 16 | S. Leary 6 | R. Miner 9 |
| December 23, 2042 | UMASS LOWELL RIVER HAWKS | W 76-71 | 2-7 | K. Akers 22 | S. Leary 4 | R. Miner 9 |
| December 28, 2042 | @ #2 Kansas Jayhawks* | L 66-89 | 2-8 | S. Leary 15 | S. Leary 4 | G. Roland 7 |
| December 30, 2042 | KANSAS STATE WILDCATS* | L 73-77 | 2-9 | G. Roland 13 | K. Akers 6 | G. Roland 6 |
| January 4, 2043 | @ UCF Knights* | L 59-89 | 2-10 | J. Tolbert 12 | S. Leary 3 | S. Leary 5 |
| January 6, 2043 | COLORADO BUFFALOES* | W 89-78 | 3-10 | S. Leary 18 | S. Leary 5 | R. Miner 9 |
| January 9, 2043 | #9 WEST VIRGINIA MOUNTAINEERS* | L 61-73 | 3-11 | K. Akers 21 | S. Leary 5 | K. Akers 6 |
| January 13, 2043 | @ #15 Oklahoma State Cowboys* | L 69-78 | 3-12 | S. Leary 14 | B. McIntosh 4 | R. Miner 8 |
| January 18, 2043 | @ TCU Horned Frogs* | L 69-85 | 3-13 | K. Akers 20 | J. Tolbert 3 | K. Akers 11 |
| January 20, 2043 | TEXAS TECH RED RAIDERS* | L 72-75 | 3-14 | K. Akers 18 | S. Leary 5 | J. Tolbert 7 |
| January 25, 2043 | @ Kansas State Wildcats* | L 61-79 | 3-15 | K. Akers 10 | S. Leary 2 | R. Miner 6 |
| January 27, 2043 | CINCINNATI BEARCATS* | L 62-81 | 3-16 | K. Akers 17 | S. Leary 5 | G. Roland 11 |
| February 1, 2043 | #23 HOUSTON COUGARS* | L 65-92 | 3-17 | J. Tolbert 25 | S. Leary 8 | G. Roland 7 |
| February 6, 2043 | @ Arizona Wildcats* | L 70-78 | 3-18 | K. Akers 13 | M. Evans 4 | K. Akers 10 |
| February 8, 2043 | @ BYU Cougars* | L 69-89 | 3-19 | J. Tolbert 13 | K. Akers 4 | K. Akers 8 |
| February 10, 2043 | ARIZONA STATE SUN DEVILS* | L 64-87 | 3-20 | J. Tolbert 11 | M. Evans 7 | G. Roland 6 |
| February 15, 2043 | #2 BAYLOR BEARS* | L 75-95 | 3-21 | S. Leary 12 | S. Leary 5 | G. Roland 8 |
| February 20, 2043 | @ Houston Cougars* | L 71-91 | 3-22 | K. Akers 25 | S. Leary 5 | R. Miner 8 |
| February 22, 2043 | #4 KANSAS JAYHAWKS* | L 81-85 | 3-23 | J. Tolbert 18 | S. Leary 9 | R. Miner 9 |
| February 24, 2043 | @ Utah Utes* | L 76-81 | 3-24 | S. Leary 21 | S. Leary 4 | G. Roland 6 |
| March 1, 2043 | @ Cincinnati Bearcats* | L 71-84 | 3-25 | J. Tolbert 25 | S. Leary 8 | L. Quick 11 |
| March 3, 2043 | BYU COUGARS* | W 88-86 | 4-25 | K. Akers 17 | S. Leary 7 | L. Quick 12 |
| March 8, 2043 | @ Utah Utes Big 12 Tournament | L 56-87 | 4-26 | J. Tolbert 17 | S. Leary 7 | J. Tolbert 4 |
