| November 16, 2042 | PROVIDENCE FRIARS | W 83-66 | 1-0 | C. Franklin 23 | C. Franklin 6 | K. Wilden 10 |
| November 19, 2042 | ILLINOIS STATE REDBIRDS | W 75-60 | 2-0 | G. Hammond 21 | C. Franklin 7 | K. Wilden 12 |
| November 23, 2042 | UTSA ROADRUNNERS | W 77-58 | 3-0 | G. Hammond 22 | C. Franklin 9 | R. Smith 12 |
| November 26, 2042 | @ Loyola Marymount Lions | W 76-51 | 4-0 | G. Hammond 10 | C. Franklin 4 | D. Daniels 6 |
| November 30, 2042 | @ Oregon State Beavers | L 61-67 | 4-1 | M. Chandler 19 | C. Franklin 5 | M. Chandler 9 |
| December 3, 2042 | @ Pepperdine Waves | L 73-87 | 4-2 | G. Hammond 14 | C. Franklin 8 | R. Smith 9 |
| December 5, 2042 | JACKSONVILLE DOLPHINS | W 84-65 | 5-2 | R. Smith 23 | C. Franklin 6 | K. Wilden 10 |
| December 13, 2042 | @ Missouri Tigers | W 76-72 | 6-2 | M. Chandler 18 | G. Hammond 6 | R. Smith 10 |
| December 21, 2042 | SOUTH CAROLINA GAMECOCKS | W 94-77 | 7-2 | M. Chandler 25 | G. Hammond 6 | K. Wilden 10 |
| December 26, 2042 | @ Northwestern Wildcats (5-6, 0-0, 2-3 Home)* | - | | | | |
| December 28, 2042 | MICHIGAN STATE SPARTANS (7-3, 0-0, 1-3 Away)* | - | | | | |
| January 2, 2043 | NEBRASKA CORNHUSKERS (3-6, 0-0, 0-2 Away)* | - | | | | |
| January 4, 2043 | @ Michigan Wolverines (4-5, 0-0, 4-2 Home)* | - | | | | |
| January 9, 2043 | @ Oregon Ducks (4-5, 0-0, 4-2 Home)* | - | | | | |
| January 11, 2043 | @ Minnesota Golden Gophers (9-2, 0-0, 5-1 Home)* | - | | | | |
| January 16, 2043 | MARYLAND TERRAPINS (7-3, 0-0, 1-2 Away)* | - | | | | |
| January 18, 2043 | @ Penn State Nittany Lions (6-3, 0-0, 5-0 Home)* | - | | | | |
| January 23, 2043 | USC TROJANS (8-2, 0-0, 0-2 Away)* | - | | | | |
| January 25, 2043 | RUTGERS SCARLET KNIGHTS (8-1, 0-0, 0-0 Away)* | - | | | | |
| January 30, 2043 | @ Ohio State Buckeyes (4-5, 0-0, 4-3 Home)* | - | | | | |
| February 1, 2043 | IOWA HAWKEYES (9-1, 0-0, 3-1 Away)* | - | | | | |
| February 6, 2043 | INDIANA HOOSIERS (7-4, 0-0, 1-3 Away)* | - | | | | |
| February 8, 2043 | WISCONSIN BADGERS (5-4, 0-0, 0-1 Away)* | - | | | | |
| February 13, 2043 | @ Washington Huskies (3-6, 0-0, 3-2 Home)* | - | | | | |
| February 15, 2043 | UCLA BRUINS (5-5, 0-0, 0-1 Away)* | - | | | | |
| February 20, 2043 | @ Purdue Boilermakers (10-1, 0-0, 7-1 Home)* | - | | | | |
| February 22, 2043 | @ Wisconsin Badgers (5-4, 0-0, 5-2 Home)* | - | | | | |
| February 27, 2043 | @ Rutgers Scarlet Knights (8-1, 0-0, 8-0 Home)* | - | | | | |
| March 1, 2043 | WASHINGTON HUSKIES (3-6, 0-0, 0-3 Away)* | - | | | | |
