| November 16, 2042 | PROVIDENCE FRIARS | W 83-66 | 1-0 | C. Franklin 23 | C. Franklin 6 | K. Wilden 10 |
| November 19, 2042 | ILLINOIS STATE REDBIRDS | W 75-60 | 2-0 | G. Hammond 21 | C. Franklin 7 | K. Wilden 12 |
| November 23, 2042 | UTSA ROADRUNNERS | W 77-58 | 3-0 | G. Hammond 22 | C. Franklin 9 | R. Smith 12 |
| November 26, 2042 | @ Loyola Marymount Lions | W 76-51 | 4-0 | G. Hammond 10 | C. Franklin 4 | D. Daniels 6 |
| November 30, 2042 | @ Oregon State Beavers | L 61-67 | 4-1 | M. Chandler 19 | C. Franklin 5 | M. Chandler 9 |
| December 3, 2042 | @ Pepperdine Waves | L 73-87 | 4-2 | G. Hammond 14 | C. Franklin 8 | R. Smith 9 |
| December 5, 2042 | JACKSONVILLE DOLPHINS | W 84-65 | 5-2 | R. Smith 23 | C. Franklin 6 | K. Wilden 10 |
| December 13, 2042 | @ Missouri Tigers | W 76-72 | 6-2 | M. Chandler 18 | G. Hammond 6 | R. Smith 10 |
| December 21, 2042 | SOUTH CAROLINA GAMECOCKS | W 94-77 | 7-2 | M. Chandler 25 | G. Hammond 6 | K. Wilden 10 |
| December 26, 2042 | @ Northwestern Wildcats* | L 77-79 | 7-3 | M. Chandler 29 | C. Franklin 4 | M. Chandler 9 |
| December 28, 2042 | MICHIGAN STATE SPARTANS* | W 68-59 | 8-3 | M. Chandler 25 | C. Franklin 6 | R. Smith 10 |
| January 2, 2043 | NEBRASKA CORNHUSKERS* | W 75-58 | 9-3 | M. Chandler 15 | C. Franklin 5 | R. Smith 13 |
| January 4, 2043 | @ Michigan Wolverines* | L 81-86 | 9-4 | M. Chandler 27 | C. Franklin 3 | D. Alston 9 |
| January 9, 2043 | @ Oregon Ducks* | L 64-87 | 9-5 | M. Chandler 25 | C. Franklin 5 | R. Smith 8 |
| January 11, 2043 | @ #7 Minnesota Golden Gophers* | L 73-84 | 9-6 | G. Hammond 19 | C. Franklin 3 | R. Smith 14 |
| January 16, 2043 | #10 MARYLAND TERRAPINS* | W 91-77 | 10-6 | M. Chandler 30 | C. Franklin 5 | K. Wilden 9 |
| January 18, 2043 | @ Penn State Nittany Lions* | W 87-80 | 11-6 | M. Chandler 24 | C. Franklin 6 | R. Smith 11 |
| January 23, 2043 | USC TROJANS* | W 71-69 | 12-6 | M. Chandler 25 | C. Franklin 5 | M. Chandler 9 |
| January 25, 2043 | RUTGERS SCARLET KNIGHTS* | W 89-82 | 13-6 | M. Chandler 33 | C. Franklin 6 | M. Chandler 13 |
| January 30, 2043 | @ Ohio State Buckeyes* | W 74-59 | 14-6 | G. Hammond 15 | D. Daniels 5 | K. Wilden 9 |
| February 1, 2043 | #17 IOWA HAWKEYES* | W 72-67 | 15-6 | G. Hammond 16 | C. Franklin 4 | D. Alston 7 |
| February 6, 2043 | INDIANA HOOSIERS* | L 54-73 | 15-7 | M. Chandler 17 | M. Chandler 4 | R. Smith 11 |
| February 8, 2043 | WISCONSIN BADGERS* | W 81-63 | 16-7 | G. Hammond 26 | G. Hammond 4 | R. Smith 7 |
| February 13, 2043 | @ Washington Huskies* | W 70-68 | 17-7 | M. Chandler 17 | C. Franklin 7 | K. Wilden 12 |
| February 15, 2043 | UCLA BRUINS* | W 92-57 | 18-7 | G. Hammond 19 | C. Franklin 4 | K. Wilden 8 |
| February 20, 2043 | @ #8 Purdue Boilermakers* | L 71-89 | 18-8 | G. Hammond 13 | C. Franklin 5 | R. Smith 9 |
| February 22, 2043 | @ Wisconsin Badgers* | L 67-79 | 18-9 | M. Chandler 16 | C. Franklin 6 | K. Wilden 7 |
| February 27, 2043 | @ Rutgers Scarlet Knights* | W 77-65 | 19-9 | M. Chandler 29 | C. Franklin 8 | K. Wilden 6 |
| March 1, 2043 | WASHINGTON HUSKIES* | W 81-67 | 20-9 | M. Chandler 20 | C. Franklin 8 | R. Smith 6 |
| March 9, 2043 | MICHIGAN WOLVERINES Big 10 Tournament | W 75-71 | 21-9 | M. Chandler 16 | C. Franklin 6 | C. Franklin 5 |
| March 10, 2043 | @ #7 Purdue Boilermakers Big 10 Tournament | L 69-84 | 21-10 | C. Franklin 17 | D. Alston 3 | K. Wilden 9 |
| March 16, 2043 | @ Charlotte 49ers NCAA Tournament | L 75-81 | 21-11 | G. Hammond 17 | C. Franklin 2 | R. Smith 12 |
