| November 15, 2042 | @ Rice Owls | W 96-81 | 1-0 | J. Burrough 21 | E. Rosas 7 | V. Underwood 10 |
| November 18, 2042 | @ Eastern Washington Eagles | W 88-76 | 2-0 | L. Harris 14 | R. Toledo 3 | L. Harris 7 |
| November 22, 2042 | SAINT JOSEPH'S HAWKS | L 61-64 | 2-1 | V. Underwood 15 | R. Toledo 3 | L. Harris 7 |
| November 25, 2042 | STEPHEN F. AUSTIN LUMBERJACKS ESPN Events Invitational | W 92-69 | 3-1 | J. Blackwell 16 | R. Toledo 9 | L. Harris 10 |
| November 26, 2042 | @ Western Kentucky Hilltoppers ESPN Events Invitational | W 96-90 | 4-1 | V. Underwood 17 | R. Toledo 8 | V. Underwood 8 |
| November 27, 2042 | @ Bucknell Bison ESPN Events Invitational | W 102-75 | 5-1 | V. Underwood 21 | J. Burrough 4 | V. Underwood 12 |
| November 29, 2042 | MARSHALL THUNDERING HERD | W 82-68 | 6-1 | L. May 16 | R. Toledo 7 | T. Smith 8 |
| December 2, 2042 | @ Villanova Wildcats | L 85-88 | 6-2 | L. May 19 | L. May 4 | V. Underwood 9 |
| December 7, 2042 | @ UTSA Roadrunners | L 92-94 | 6-3 | L. May 18 | J. Blackwell 7 | J. Burrough 7 |
| December 13, 2042 | IU INDY JAGUARS | W 84-55 | 7-3 | L. Harris 23 | L. May 5 | J. Burrough 7 |
| December 20, 2042 | @ Liberty Flames | W 74-60 | 8-3 | L. May 15 | J. Blackwell 5 | T. Smith 14 |
| December 26, 2042 | @ Northern Iowa Panthers* | W 71-50 | 9-3 | J. Burrough 12 | R. Toledo 3 | L. Harris 12 |
| December 29, 2042 | @ UIC Flames* | W 98-80 | 10-3 | T. Smith 23 | J. Burrough 4 | T. Smith 10 |
| January 2, 2043 | ILLINOIS STATE REDBIRDS* | W 78-61 | 11-3 | L. May 17 | L. May 5 | T. Smith 9 |
| January 5, 2043 | BELMONT BRUINS* | W 86-63 | 12-3 | L. May 24 | J. Blackwell 7 | T. Smith 12 |
| January 9, 2043 | DRAKE BULLDOGS* | W 94-72 | 13-3 | L. May 30 | C. McClellan 7 | J. Burrough 10 |
| January 12, 2043 | @ Valparaiso Crusaders* | W 80-70 | 14-3 | L. Harris 13 | L. May 5 | T. Smith 10 |
| January 16, 2043 | MURRAY STATE RACERS* | W 87-70 | 15-3 | T. Smith 18 | T. Smith 5 | J. Burrough 7 |
| January 19, 2043 | @ Southern Illinois Salukis* | L 77-86 | 15-4 | J. Blackwell 25 | J. Blackwell 4 | L. Harris 6 |
| January 23, 2043 | @ Bradley Braves* | L 85-98 | 15-5 | T. Smith 24 | T. Smith 5 | L. Harris 10 |
| January 26, 2043 | @ Murray State Racers* | L 58-88 | 15-6 | L. May 13 | T. Smith 3 | T. Smith 10 |
| January 30, 2043 | SOUTHERN ILLINOIS SALUKIS* | W 90-75 | 16-6 | J. Blackwell 18 | J. Blackwell 9 | V. Underwood 8 |
| February 2, 2043 | BRADLEY BRAVES* | W 79-67 | 17-6 | J. Burrough 25 | J. Blackwell 3 | J. Burrough 7 |
| February 6, 2043 | VALPARAISO CRUSADERS* | W 101-68 | 18-6 | L. May 28 | J. Blackwell 7 | L. Harris 9 |
| February 9, 2043 | MISSOURI STATE BEARS* | W 84-74 | 19-6 | L. May 17 | L. May 4 | T. Smith 12 |
| February 13, 2043 | @ Illinois State Redbirds* | W 75-68 | 20-6 | L. Harris 20 | J. Blackwell 3 | L. Harris 9 |
| February 16, 2043 | @ Belmont Bruins* | W 95-86 | 21-6 | T. Smith 27 | J. Blackwell 7 | T. Smith 11 |
| February 20, 2043 | NORTHERN IOWA PANTHERS* | W 82-64 | 22-6 | C. McClellan 14 | L. Harris 4 | L. Harris 6 |
| February 23, 2043 | @ Missouri State Bears* | W 89-77 | 23-6 | C. McClellan 20 | C. McClellan 5 | V. Underwood 9 |
| February 27, 2043 | UIC FLAMES* | W 98-64 | 24-6 | C. McClellan 21 | C. McClellan 7 | J. Burrough 10 |
| March 2, 2043 | @ Evansville Purple Aces* | L 70-85 | 24-7 | L. Harris 14 | C. McClellan 6 | L. Harris 6 |
| March 7, 2043 | ILLINOIS STATE REDBIRDS MVC Tournament | L 75-82 | 24-8 | L. May 13 | T. Smith 4 | T. Smith 19 |
| March 14, 2043 | UCF KNIGHTS NCAA Tournament | L 80-92 | 24-9 | C. McClellan 14 | C. McClellan 6 | T. Smith 9 |
