| November 16, 2042 | SOUTHERN INDIANA SCREAMING EAGLES | W 86-67 | 1-0 | M. Giordano 33 | S. Dawson 11 | S. Rushing 10 |
| November 19, 2042 | @ Providence Friars | W 74-68 | 2-0 | M. Giordano 29 | S. Dawson 8 | C. Lewis 13 |
| November 23, 2042 | @ #10 Wichita State Shockers | L 71-75 | 2-1 | D. Crowder 17 | S. Dawson 6 | C. Lewis 10 |
| November 30, 2042 | BRYANT BULLDOGS | W 89-64 | 3-1 | M. Giordano 24 | S. Dawson 6 | C. Lewis 12 |
| December 3, 2042 | #11 CREIGHTON BLUE JAYS | L 97-104 | 3-2 | M. Giordano 23 | S. Dawson 6 | C. Lewis 14 |
| December 7, 2042 | MONMOUTH HAWKS | W 79-58 | 4-2 | M. Giordano 16 | S. Dawson 6 | D. Crowder 11 |
| December 9, 2042 | MIAMI (OH) RED HAWKS Cayman Islands Classic | W 79-61 | 5-2 | S. Dawson 20 | F. Osmanoglu 4 | C. Lewis 13 |
| December 10, 2042 | @ Duquesne Dukes Cayman Islands Classic | W 93-72 | 6-2 | M. Giordano 24 | S. Dawson 8 | C. Lewis 13 |
| December 11, 2042 | UTAH UTES Cayman Islands Classic | W 88-69 | 7-2 | C. Lewis 18 | S. Dawson 6 | C. Lewis 12 |
| December 13, 2042 | @ Vanderbilt Commodores | L 64-78 | 7-3 | D. Crowder 12 | S. Dawson 6 | D. Crowder 9 |
| December 21, 2042 | @ Cincinnati Bearcats | L 60-75 | 7-4 | M. Giordano 18 | S. Dawson 3 | C. Lewis 9 |
| December 26, 2042 | @ Ohio State Buckeyes (4-5, 0-0, 4-3 Home)* | - | | | | |
| December 28, 2042 | PENN STATE NITTANY LIONS (6-3, 0-0, 1-2 Away)* | - | | | | |
| January 2, 2043 | @ Rutgers Scarlet Knights (8-1, 0-0, 8-0 Home)* | - | | | | |
| January 4, 2043 | WISCONSIN BADGERS (5-4, 0-0, 0-1 Away)* | - | | | | |
| January 9, 2043 | @ Maryland Terrapins (7-3, 0-0, 5-0 Home)* | - | | | | |
| January 11, 2043 | @ Iowa Hawkeyes (9-1, 0-0, 4-0 Home)* | - | | | | |
| January 16, 2043 | PURDUE BOILERMAKERS (10-1, 0-0, 0-0 Away)* | - | | | | |
| January 18, 2043 | @ UCLA Bruins (5-5, 0-0, 4-3 Home)* | - | | | | |
| January 23, 2043 | NORTHWESTERN WILDCATS (5-6, 0-0, 1-2 Away)* | - | | | | |
| January 25, 2043 | MICHIGAN STATE SPARTANS (7-3, 0-0, 1-3 Away)* | - | | | | |
| January 30, 2043 | NEBRASKA CORNHUSKERS (3-6, 0-0, 0-2 Away)* | - | | | | |
| February 1, 2043 | @ Michigan Wolverines (4-5, 0-0, 4-2 Home)* | - | | | | |
| February 6, 2043 | @ Illinois Fighting Illini (7-2, 0-0, 5-0 Home)* | - | | | | |
| February 8, 2043 | OREGON DUCKS (4-5, 0-0, 0-2 Away)* | - | | | | |
| February 13, 2043 | MINNESOTA GOLDEN GOPHERS (9-2, 0-0, 2-0 Away)* | - | | | | |
| February 15, 2043 | @ Washington Huskies (3-6, 0-0, 3-2 Home)* | - | | | | |
| February 20, 2043 | @ USC Trojans (8-2, 0-0, 6-0 Home)* | - | | | | |
| February 22, 2043 | USC TROJANS (8-2, 0-0, 0-2 Away)* | - | | | | |
| February 27, 2043 | @ Michigan State Spartans (7-3, 0-0, 4-0 Home)* | - | | | | |
| March 1, 2043 | MICHIGAN WOLVERINES (4-5, 0-0, 0-2 Away)* | - | | | | |
