| November 16, 2042 | SOUTHERN INDIANA SCREAMING EAGLES | W 86-67 | 1-0 | M. Giordano 33 | S. Dawson 11 | S. Rushing 10 |
| November 19, 2042 | @ Providence Friars | W 74-68 | 2-0 | M. Giordano 29 | S. Dawson 8 | C. Lewis 13 |
| November 23, 2042 | @ #10 Wichita State Shockers | L 71-75 | 2-1 | D. Crowder 17 | S. Dawson 6 | C. Lewis 10 |
| November 30, 2042 | BRYANT BULLDOGS | W 89-64 | 3-1 | M. Giordano 24 | S. Dawson 6 | C. Lewis 12 |
| December 3, 2042 | #11 CREIGHTON BLUE JAYS | L 97-104 | 3-2 | M. Giordano 23 | S. Dawson 6 | C. Lewis 14 |
| December 7, 2042 | MONMOUTH HAWKS | W 79-58 | 4-2 | M. Giordano 16 | S. Dawson 6 | D. Crowder 11 |
| December 9, 2042 | MIAMI (OH) RED HAWKS Cayman Islands Classic | W 79-61 | 5-2 | S. Dawson 20 | F. Osmanoglu 4 | C. Lewis 13 |
| December 10, 2042 | @ Duquesne Dukes Cayman Islands Classic | W 93-72 | 6-2 | M. Giordano 24 | S. Dawson 8 | C. Lewis 13 |
| December 11, 2042 | UTAH UTES Cayman Islands Classic | W 88-69 | 7-2 | C. Lewis 18 | S. Dawson 6 | C. Lewis 12 |
| December 13, 2042 | @ Vanderbilt Commodores | L 64-78 | 7-3 | D. Crowder 12 | S. Dawson 6 | D. Crowder 9 |
| December 21, 2042 | @ Cincinnati Bearcats | L 60-75 | 7-4 | M. Giordano 18 | S. Dawson 3 | C. Lewis 9 |
| December 26, 2042 | @ Ohio State Buckeyes* | W 82-77 | 8-4 | C. Lewis 20 | S. Dawson 5 | S. Rushing 8 |
| December 28, 2042 | PENN STATE NITTANY LIONS* | L 77-82 | 8-5 | M. Giordano 20 | F. Osmanoglu 3 | D. Crowder 11 |
| January 2, 2043 | @ Rutgers Scarlet Knights* | W 86-73 | 9-5 | M. Giordano 28 | S. Dawson 8 | D. Crowder 12 |
| January 4, 2043 | WISCONSIN BADGERS* | W 73-57 | 10-5 | M. Giordano 27 | S. Dawson 7 | D. Crowder 8 |
| January 9, 2043 | @ #10 Maryland Terrapins* | L 67-87 | 10-6 | D. Crowder 12 | S. Dawson 8 | C. Lewis 7 |
| January 11, 2043 | @ #19 Iowa Hawkeyes* | L 67-102 | 10-7 | M. Giordano 29 | S. Dawson 8 | C. Lewis 7 |
| January 16, 2043 | #4 PURDUE BOILERMAKERS* | W 70-65 | 11-7 | M. Giordano 20 | D. Crowder 4 | C. Lewis 11 |
| January 18, 2043 | @ UCLA Bruins* | W 83-72 | 12-7 | D. Crowder 19 | S. Dawson 9 | C. Lewis 7 |
| January 23, 2043 | NORTHWESTERN WILDCATS* | W 85-76 | 13-7 | M. Giordano 22 | S. Dawson 8 | C. Lewis 8 |
| January 25, 2043 | MICHIGAN STATE SPARTANS* | W 99-72 | 14-7 | C. Lewis 22 | C. Lewis 7 | C. Lewis 12 |
| January 30, 2043 | NEBRASKA CORNHUSKERS* | W 83-61 | 15-7 | M. Giordano 23 | S. Dawson 6 | D. Crowder 13 |
| February 1, 2043 | @ Michigan Wolverines* | L 79-82 | 15-8 | M. Giordano 20 | F. Osmanoglu 7 | C. Lewis 11 |
| February 6, 2043 | @ Illinois Fighting Illini* | W 73-54 | 16-8 | M. Giordano 21 | M. Giordano 4 | S. Rushing 10 |
| February 8, 2043 | OREGON DUCKS* | W 98-89 OT | 17-8 | S. Rushing 27 | S. Dawson 10 | D. Crowder 12 |
| February 13, 2043 | MINNESOTA GOLDEN GOPHERS (21-4, 12-2, 7-1 Away)* | - | | | | |
| February 15, 2043 | @ Washington Huskies (5-18, 2-12, 5-6 Home)* | - | | | | |
| February 20, 2043 | @ USC Trojans (16-9, 8-6, 11-1 Home)* | - | | | | |
| February 22, 2043 | USC TROJANS (16-9, 8-6, 3-7 Away)* | - | | | | |
| February 27, 2043 | @ Michigan State Spartans (15-10, 7-7, 11-1 Home)* | - | | | | |
| March 1, 2043 | MICHIGAN WOLVERINES (12-11, 8-6, 2-6 Away)* | - | | | | |
