| November 16, 2042 | BOWLING GREEN FALCONS | W 82-60 | 1-0 | M. Henry 15 | D. Wu 4 | D. Wu 12 |
| November 23, 2042 | IU INDY JAGUARS | W 80-57 | 2-0 | B. Hall 14 | C. Stewart 4 | D. Wu 11 |
| November 26, 2042 | STONY BROOK SEAWOLVES | W 86-70 | 3-0 | D. Wu 24 | M. Henry 6 | D. Wu 15 |
| November 30, 2042 | @ #24 Syracuse Orange | W 75-57 | 4-0 | C. Clay 18 | M. Henry 12 | D. Wu 13 |
| December 3, 2042 | @ Kentucky Wildcats | W 90-69 | 5-0 | C. Stewart 21 | M. Henry 6 | B. Hall 14 |
| December 7, 2042 | SOUTH CAROLINA GAMECOCKS | W 75-66 | 6-0 | C. Clay 18 | M. Henry 5 | D. Wu 14 |
| December 13, 2042 | @ Iowa State Cyclones | W 88-75 | 7-0 | C. Stewart 18 | M. Henry 7 | B. Hall 10 |
| December 21, 2042 | @ Utah Utes | L 80-82 | 7-1 | D. Wu 18 | C. Stewart 5 | B. Hall 15 |
| December 23, 2042 | VANDERBILT COMMODORES saatva Empire Classic | W 89-77 | 8-1 | D. Wu 19 | B. Hall 6 | B. Hall 12 |
| December 24, 2042 | @ Fresno State Bulldogs saatva Empire Classic | W 83-60 | 9-1 | D. Wu 22 | C. Clay 4 | D. Wu 14 |
| December 25, 2042 | @ Kansas State Wildcats saatva Empire Classic | W 77-59 | 10-1 | B. Hall 13 | M. Henry 4 | B. Hall 13 |
| December 26, 2042 | @ Michigan Wolverines* | W 86-65 | 11-1 | C. Stewart 25 | M. Henry 6 | B. Hall 10 |
| December 28, 2042 | @ UCLA Bruins* | L 53-61 | 11-2 | D. Wu 11 | M. Henry 2 | B. Hall 14 |
| January 2, 2043 | #6 MINNESOTA GOLDEN GOPHERS* | L 67-74 | 11-3 | B. Hall 19 | M. Henry 5 | B. Hall 11 |
| January 4, 2043 | #2 PURDUE BOILERMAKERS* | W 73-57 | 12-3 | B. Hall 16 | M. Henry 5 | B. Hall 15 |
| January 9, 2043 | NEBRASKA CORNHUSKERS* | W 76-58 | 13-3 | B. Hall 21 | M. Henry 6 | D. Wu 10 |
| January 11, 2043 | INDIANA HOOSIERS* | W 102-67 | 14-3 | C. Stewart 24 | B. Farmer 10 | D. Wu 12 |
| January 16, 2043 | @ Penn State Nittany Lions* | L 70-78 | 14-4 | C. Stewart 20 | C. Stewart 2 | D. Covington 12 |
| January 18, 2043 | WISCONSIN BADGERS* | W 82-66 | 15-4 | M. Henry 21 | M. Henry 7 | B. Hall 8 |
| January 23, 2043 | WASHINGTON HUSKIES* | W 84-73 | 16-4 | B. Hall 25 | D. Wu 3 | B. Hall 13 |
| January 25, 2043 | NORTHWESTERN WILDCATS* | L 64-76 | 16-5 | B. Hall 21 | M. Henry 4 | B. Hall 8 |
| January 30, 2043 | @ Rutgers Scarlet Knights* | W 62-61 | 17-5 | C. Clay 15 | M. Henry 9 | B. Hall 11 |
| February 1, 2043 | @ Illinois Fighting Illini* | L 67-72 | 17-6 | B. Hall 15 | M. Henry 5 | D. Covington 9 |
| February 6, 2043 | USC TROJANS* | L 76-89 | 17-7 | B. Hall 16 | M. Henry 3 | B. Hall 10 |
| February 8, 2043 | @ Ohio State Buckeyes* | W 74-46 | 18-7 | C. Clay 25 | M. Henry 7 | D. Wu 7 |
| February 13, 2043 | @ Maryland Terrapins (16-8, 9-5, 9-2 Home)* | - | | | | |
| February 15, 2043 | OREGON DUCKS (13-10, 9-5, 3-5 Away)* | - | | | | |
| February 20, 2043 | MICHIGAN STATE SPARTANS (15-10, 7-7, 1-9 Away)* | - | | | | |
| February 22, 2043 | @ Oregon Ducks (13-10, 9-5, 10-4 Home)* | - | | | | |
| February 27, 2043 | @ Northwestern Wildcats (12-13, 7-7, 6-6 Home)* | - | | | | |
| March 1, 2043 | @ Purdue Boilermakers (18-7, 8-6, 12-2 Home)* | - | | | | |
