| November 14, 2042 | #19 CONNECTICUT HUSKIES | W 68-51 | 1-0 | S. Mathias 21 | D. Johnston 7 | K. Skidmore 13 |
| November 17, 2042 | VANDERBILT COMMODORES | L 73-77 | 1-1 | S. Mathias 16 | D. Johnston 6 | L. Lackey 9 |
| November 23, 2042 | #6 MINNESOTA GOLDEN GOPHERS | L 70-81 | 1-2 | S. Mathias 20 | S. Mathias 5 | D. Johnston 5 |
| November 24, 2042 | #17 GEORGIA TECH YELLOW JACKETS | L 59-69 | 1-3 | T. Beshara 19 | D. Johnston 5 | M. Shook 6 |
| November 28, 2042 | @ Ole Miss Rebels | L 82-89 | 1-4 | S. Mathias 21 | D. Johnston 7 | M. Shook 6 |
| December 5, 2042 | UAB BLAZERS | W 80-57 | 2-4 | T. Beshara 16 | D. Johnston 5 | T. Beshara 9 |
| December 13, 2042 | @ #20 Mississippi State Bulldogs | W 76-74 | 3-4 | D. Pointer 17 | D. Johnston 5 | D. Pointer 8 |
| December 21, 2042 | #15 MARYLAND TERRAPINS | L 82-87 OT | 3-5 | D. Pointer 19 | D. Johnston 3 | K. Skidmore 8 |
| December 23, 2042 | UIC FLAMES saatva Empire Classic | W 85-69 | 4-5 | T. Beshara 16 | M. Shook 7 | T. Beshara 8 |
| December 24, 2042 | UTSA ROADRUNNERS saatva Empire Classic | W 83-79 | 5-5 | K. Skidmore 19 | S. Mathias 4 | M. Shook 8 |
| December 25, 2042 | IOWA HAWKEYES (9-1, 3-1 Away) saatva Empire Classic | - | | | | |
| December 26, 2042 | TEXAS TECH RED RAIDERS (6-4, 0-0, 1-2 Away)* | - | | | | |
| December 30, 2042 | @ Iowa State Cyclones (2-7, 0-0, 2-4 Home)* | - | | | | |
| January 4, 2043 | @ West Virginia Mountaineers (9-2, 0-0, 6-1 Home)* | - | | | | |
| January 9, 2043 | TCU HORNED FROGS (7-3, 0-0, 0-2 Away)* | - | | | | |
| January 11, 2043 | OKLAHOMA STATE COWBOYS (10-1, 0-0, 0-0 Away)* | - | | | | |
| January 13, 2043 | @ Arizona Wildcats (3-6, 0-0, 3-2 Home)* | - | | | | |
| January 18, 2043 | KANSAS JAYHAWKS (10-1, 0-0, 1-1 Away)* | - | | | | |
| January 20, 2043 | @ Cincinnati Bearcats (8-2, 0-0, 6-2 Home)* | - | | | | |
| January 25, 2043 | IOWA STATE CYCLONES (2-7, 0-0, 0-2 Away)* | - | | | | |
| January 30, 2043 | @ Arizona State Sun Devils (7-3, 0-0, 5-2 Home)* | - | | | | |
| February 1, 2043 | @ Utah Utes (7-4, 0-0, 5-3 Home)* | - | | | | |
| February 3, 2043 | BAYLOR BEARS (11-1, 0-0, 1-0 Away)* | - | | | | |
| February 8, 2043 | @ UCF Knights (5-4, 0-0, 5-0 Home)* | - | | | | |
| February 10, 2043 | WEST VIRGINIA MOUNTAINEERS (9-2, 0-0, 0-1 Away)* | - | | | | |
| February 15, 2043 | @ Texas Tech Red Raiders (6-4, 0-0, 4-1 Home)* | - | | | | |
| February 17, 2043 | COLORADO BUFFALOES (6-4, 0-0, 1-1 Away)* | - | | | | |
| February 20, 2043 | UCF KNIGHTS (5-4, 0-0, 0-3 Away)* | - | | | | |
| February 27, 2043 | @ Houston Cougars (7-2, 0-0, 7-0 Home)* | - | | | | |
| March 1, 2043 | @ BYU Cougars (7-3, 0-0, 5-0 Home)* | - | | | | |
| March 3, 2043 | ARIZONA STATE SUN DEVILS (7-3, 0-0, 1-0 Away)* | - | | | | |
