| November 14, 2042 | #19 CONNECTICUT HUSKIES | W 68-51 | 1-0 | S. Mathias 21 | D. Johnston 7 | K. Skidmore 13 |
| November 17, 2042 | VANDERBILT COMMODORES | L 73-77 | 1-1 | S. Mathias 16 | D. Johnston 6 | L. Lackey 9 |
| November 23, 2042 | #6 MINNESOTA GOLDEN GOPHERS | L 70-81 | 1-2 | S. Mathias 20 | S. Mathias 5 | D. Johnston 5 |
| November 24, 2042 | #17 GEORGIA TECH YELLOW JACKETS | L 59-69 | 1-3 | T. Beshara 19 | D. Johnston 5 | M. Shook 6 |
| November 28, 2042 | @ Ole Miss Rebels | L 82-89 | 1-4 | S. Mathias 21 | D. Johnston 7 | M. Shook 6 |
| December 5, 2042 | UAB BLAZERS | W 80-57 | 2-4 | T. Beshara 16 | D. Johnston 5 | T. Beshara 9 |
| December 13, 2042 | @ #20 Mississippi State Bulldogs | W 76-74 | 3-4 | D. Pointer 17 | D. Johnston 5 | D. Pointer 8 |
| December 21, 2042 | #15 MARYLAND TERRAPINS | L 82-87 OT | 3-5 | D. Pointer 19 | D. Johnston 3 | K. Skidmore 8 |
| December 23, 2042 | UIC FLAMES saatva Empire Classic | W 85-69 | 4-5 | T. Beshara 16 | M. Shook 7 | T. Beshara 8 |
| December 24, 2042 | UTSA ROADRUNNERS saatva Empire Classic | W 83-79 | 5-5 | K. Skidmore 19 | S. Mathias 4 | M. Shook 8 |
| December 25, 2042 | #22 IOWA HAWKEYES saatva Empire Classic | L 59-77 | 5-6 | S. Mathias 19 | D. Johnston 10 | M. Shook 6 |
| December 26, 2042 | TEXAS TECH RED RAIDERS* | W 82-64 | 6-6 | S. Mathias 19 | D. Colbert 5 | K. Skidmore 8 |
| December 30, 2042 | @ Iowa State Cyclones* | W 77-73 | 7-6 | S. Mathias 27 | D. Johnston 6 | D. Pointer 9 |
| January 4, 2043 | @ #11 West Virginia Mountaineers* | L 68-79 | 7-7 | S. Mathias 18 | D. Johnston 4 | D. Pointer 7 |
| January 9, 2043 | TCU HORNED FROGS* | W 85-75 | 8-7 | T. Beshara 23 | S. Mathias 7 | T. Beshara 9 |
| January 11, 2043 | #15 OKLAHOMA STATE COWBOYS* | L 70-79 | 8-8 | S. Mathias 18 | D. Johnston 5 | T. Beshara 8 |
| January 13, 2043 | @ Arizona Wildcats* | W 78-64 | 9-8 | S. Mathias 19 | S. Mathias 7 | K. Skidmore 7 |
| January 18, 2043 | #3 KANSAS JAYHAWKS* | L 81-92 | 9-9 | T. Beshara 21 | D. Johnston 5 | D. Pointer 7 |
| January 20, 2043 | @ Cincinnati Bearcats* | L 61-66 | 9-10 | D. Johnston 12 | D. Johnston 4 | T. Beshara 10 |
| January 25, 2043 | IOWA STATE CYCLONES* | W 79-61 | 10-10 | D. Pointer 14 | D. Johnston 5 | K. Skidmore 10 |
| January 30, 2043 | @ Arizona State Sun Devils* | L 52-76 | 10-11 | T. Beshara 14 | D. Johnston 6 | M. Shook 6 |
| February 1, 2043 | @ Utah Utes* | W 80-54 | 11-11 | T. Beshara 13 | S. Mathias 5 | M. Shook 8 |
| February 3, 2043 | #2 BAYLOR BEARS* | L 71-90 | 11-12 | S. Mathias 16 | D. Johnston 7 | T. Beshara 9 |
| February 8, 2043 | @ UCF Knights* | L 64-72 | 11-13 | S. Mathias 17 | D. Johnston 3 | K. Skidmore 12 |
| February 10, 2043 | #12 WEST VIRGINIA MOUNTAINEERS* | L 57-65 | 11-14 | S. Mathias 18 | D. Johnston 4 | T. Beshara 13 |
| February 15, 2043 | @ Texas Tech Red Raiders (10-14, 4-10, 6-6 Home)* | - | | | | |
| February 17, 2043 | COLORADO BUFFALOES (13-11, 7-7, 4-5 Away)* | - | | | | |
| February 20, 2043 | UCF KNIGHTS (14-9, 9-5, 3-7 Away)* | - | | | | |
| February 27, 2043 | @ Houston Cougars (16-7, 9-5, 12-2 Home)* | - | | | | |
| March 1, 2043 | @ BYU Cougars (15-9, 8-6, 10-2 Home)* | - | | | | |
| March 3, 2043 | ARIZONA STATE SUN DEVILS (15-9, 8-6, 4-4 Away)* | - | | | | |
