| November 15, 2042 | @ Cincinnati Bearcats | W 80-66 | 1-0 | C. Parra 23 | D. Greenberg 8 | C. Morse 7 |
| November 19, 2042 | @ #11 Florida State Seminoles | L 50-70 | 1-1 | C. Barlow 14 | D. Greenberg 2 | T. Carpenter 8 |
| November 23, 2042 | @ #12 NC State Wolfpack | L 64-76 | 1-2 | D. Norris 15 | C. Parra 4 | T. Carpenter 8 |
| November 25, 2042 | @ Kentucky Wildcats | W 93-90 | 2-2 | C. Morse 18 | D. Greenberg 7 | C. Barlow 7 |
| November 30, 2042 | @ Princeton Tigers | W 86-77 | 3-2 | D. Greenberg 20 | D. Greenberg 6 | C. Parra 9 |
| December 3, 2042 | @ Yale Bulldogs | L 77-82 | 3-3 | D. Greenberg 17 | D. Greenberg 7 | D. Norris 11 |
| December 13, 2042 | YOUNGSTOWN STATE PENGUINS | W 84-75 | 4-3 | C. Parra 19 | D. Greenberg 8 | D. Norris 6 |
| December 19, 2042 | @ Niagara Purple Eagles | L 56-63 | 4-4 | D. Norris 12 | D. Greenberg 4 | D. Norris 10 |
| December 23, 2042 | @ Temple Owls Gulf Coast Showcase | W 69-53 | 5-4 | C. Barlow 20 | D. Greenberg 7 | C. Morse 8 |
| December 24, 2042 | @ East Tennessee State Buccaneers Gulf Coast Showcase | W 87-77 | 6-4 | C. Parra 31 | D. Greenberg 4 | T. Carpenter 8 |
| December 25, 2042 | MICHIGAN STATE SPARTANS (7-3, 1-3 Away) Gulf Coast Showcase | - | | | | |
| December 26, 2042 | @ Miami (OH) Red Hawks (3-6, 0-0, 3-1 Home)* | - | | | | |
| December 29, 2042 | @ Buffalo Bulls (4-5, 0-0, 4-0 Home)* | - | | | | |
| January 2, 2043 | CENTRAL MICHIGAN CHIPPEWAS (4-5, 0-0, 1-5 Away)* | - | | | | |
| January 5, 2043 | NORTHERN ILLINOIS HUSKIES (6-3, 0-0, 1-3 Away)* | - | | | | |
| January 9, 2043 | EASTERN MICHIGAN EAGLES (5-4, 0-0, 3-3 Away)* | - | | | | |
| January 12, 2043 | @ Akron Zips (7-2, 0-0, 4-0 Home)* | - | | | | |
| January 16, 2043 | @ Ohio Bobcats (6-4, 0-0, 5-1 Home)* | - | | | | |
| January 19, 2043 | WESTERN MICHIGAN BRONCOS (5-4, 0-0, 2-2 Away)* | - | | | | |
| January 23, 2043 | BALL STATE CARDINALS (2-7, 0-0, 1-5 Away)* | - | | | | |
| January 26, 2043 | @ Bowling Green Falcons (3-6, 0-0, 3-0 Home)* | - | | | | |
| January 30, 2043 | @ Western Michigan Broncos (5-4, 0-0, 3-2 Home)* | - | | | | |
| February 2, 2043 | @ Ball State Cardinals (2-7, 0-0, 1-2 Home)* | - | | | | |
| February 6, 2043 | AKRON ZIPS (7-2, 0-0, 3-1 Away)* | - | | | | |
| February 9, 2043 | OHIO BOBCATS (6-4, 0-0, 0-2 Away)* | - | | | | |
| February 13, 2043 | @ Central Michigan Chippewas (4-5, 0-0, 3-0 Home)* | - | | | | |
| February 16, 2043 | @ Northern Illinois Huskies (6-3, 0-0, 5-0 Home)* | - | | | | |
| February 20, 2043 | MIAMI (OH) RED HAWKS (3-6, 0-0, 0-4 Away)* | - | | | | |
| February 23, 2043 | BUFFALO BULLS (4-5, 0-0, 0-4 Away)* | - | | | | |
| February 27, 2043 | BOWLING GREEN FALCONS (3-6, 0-0, 0-6 Away)* | - | | | | |
| March 2, 2043 | @ Toledo Rockets (5-5, 0-0, 3-0 Home)* | - | | | | |
