| November 15, 2042 | @ Saint Louis Billikens | L 73-88 | 0-1 | D. Holden 16 | N. Houston 7 | D. Holden 11 |
| November 17, 2042 | TCU HORNED FROGS | W 93-84 | 1-1 | D. Quezada 19 | D. Holden 6 | E. Hammond 8 |
| November 21, 2042 | GEORGIA BULLDOGS WSSN Classic | W 74-54 | 2-1 | J. Charity 12 | N. Houston 5 | E. Hammond 17 |
| November 22, 2042 | @ Creighton Blue Jays WSSN Classic | L 59-72 | 2-2 | V. Landry 12 | D. Quezada 3 | D. Holden 8 |
| November 24, 2042 | MD-EASTERN SHORE HAWKS | W 86-65 | 3-2 | E. Hammond 13 | J. Charity 4 | D. Holden 9 |
| November 29, 2042 | @ Mississippi State Bulldogs | L 72-77 | 3-3 | D. Holden 13 | N. Houston 7 | E. Hammond 11 |
| December 2, 2042 | @ George Mason Patriots | L 67-81 | 3-4 | D. Holden 16 | V. Landry 4 | E. Hammond 10 |
| December 7, 2042 | GEORGETOWN HOYAS | W 72-63 | 4-4 | D. Quezada 15 | V. Landry 4 | E. Hammond 13 |
| December 10, 2042 | @ Penn State Nittany Lions | L 64-83 | 4-5 | D. Quezada 13 | N. Houston 5 | D. Holden 9 |
| December 13, 2042 | ARKANSAS RAZORBACKS | L 66-71 | 4-6 | D. Quezada 12 | N. Houston 6 | E. Hammond 15 |
| December 17, 2042 | APP STATE MOUNTAINEERS | L 62-69 | 4-7 | N. Houston 15 | N. Houston 3 | E. Hammond 10 |
| December 21, 2042 | #6 NORTH CAROLINA TAR HEELS | L 61-65 | 4-8 | D. Quezada 13 | N. Houston 10 | E. Hammond 9 |
| January 2, 2043 | FLORIDA ATLANTIC OWLS (5-4, 0-0, 2-1 Away)* | - | | | | |
| January 5, 2043 | TULSA GOLDEN HURRICANES (5-6, 0-0, 0-3 Away)* | - | | | | |
| January 9, 2043 | @ UTSA Roadrunners (4-7, 0-0, 3-3 Home)* | - | | | | |
| January 12, 2043 | @ Charlotte 49ers (8-5, 0-0, 4-0 Home)* | - | | | | |
| January 14, 2043 | @ UAB Blazers (3-8, 0-0, 2-4 Home)* | - | | | | |
| January 16, 2043 | NORTH TEXAS MEAN GREEN (4-6, 0-0, 1-3 Away)* | - | | | | |
| January 19, 2043 | @ Wichita State Shockers (10-2, 0-0, 6-0 Home)* | - | | | | |
| January 23, 2043 | UAB BLAZERS (3-8, 0-0, 0-3 Away)* | - | | | | |
| January 26, 2043 | @ Florida Atlantic Owls (5-4, 0-0, 3-2 Home)* | - | | | | |
| January 30, 2043 | @ South Florida Bulls (9-2, 0-0, 8-1 Home)* | - | | | | |
| February 6, 2043 | TEMPLE OWLS (4-6, 0-0, 0-1 Away)* | - | | | | |
| February 9, 2043 | @ Rice Owls (3-7, 0-0, 3-3 Home)* | - | | | | |
| February 13, 2043 | @ Tulane Green Wave (7-3, 0-0, 5-0 Home)* | - | | | | |
| February 16, 2043 | EAST CAROLINA PIRATES (5-5, 0-0, 1-4 Away)* | - | | | | |
| February 20, 2043 | CHARLOTTE 49ERS (8-5, 0-0, 1-4 Away)* | - | | | | |
| February 23, 2043 | WICHITA STATE SHOCKERS (10-2, 0-0, 2-1 Away)* | - | | | | |
| February 27, 2043 | UTSA ROADRUNNERS (4-7, 0-0, 0-3 Away)* | - | | | | |
| March 2, 2043 | @ North Texas Mean Green (4-6, 0-0, 3-2 Home)* | - | | | | |
