| November 15, 2042 | @ Saint Louis Billikens | L 73-88 | 0-1 | D. Holden 16 | N. Houston 7 | D. Holden 11 |
| November 17, 2042 | TCU HORNED FROGS | W 93-84 | 1-1 | D. Quezada 19 | D. Holden 6 | E. Hammond 8 |
| November 21, 2042 | GEORGIA BULLDOGS WSSN Classic | W 74-54 | 2-1 | J. Charity 12 | N. Houston 5 | E. Hammond 17 |
| November 22, 2042 | @ Creighton Blue Jays WSSN Classic | L 59-72 | 2-2 | V. Landry 12 | D. Quezada 3 | D. Holden 8 |
| November 24, 2042 | MD-EASTERN SHORE HAWKS | W 86-65 | 3-2 | E. Hammond 13 | J. Charity 4 | D. Holden 9 |
| November 29, 2042 | @ Mississippi State Bulldogs | L 72-77 | 3-3 | D. Holden 13 | N. Houston 7 | E. Hammond 11 |
| December 2, 2042 | @ George Mason Patriots | L 67-81 | 3-4 | D. Holden 16 | V. Landry 4 | E. Hammond 10 |
| December 7, 2042 | GEORGETOWN HOYAS | W 72-63 | 4-4 | D. Quezada 15 | V. Landry 4 | E. Hammond 13 |
| December 10, 2042 | @ Penn State Nittany Lions | L 64-83 | 4-5 | D. Quezada 13 | N. Houston 5 | D. Holden 9 |
| December 13, 2042 | ARKANSAS RAZORBACKS | L 66-71 | 4-6 | D. Quezada 12 | N. Houston 6 | E. Hammond 15 |
| December 17, 2042 | APP STATE MOUNTAINEERS | L 62-69 | 4-7 | N. Houston 15 | N. Houston 3 | E. Hammond 10 |
| December 21, 2042 | #6 NORTH CAROLINA TAR HEELS | L 61-65 | 4-8 | D. Quezada 13 | N. Houston 10 | E. Hammond 9 |
| January 2, 2043 | FLORIDA ATLANTIC OWLS* | W 65-62 | 5-8 | N. Houston 11 | N. Houston 5 | E. Hammond 9 |
| January 5, 2043 | TULSA GOLDEN HURRICANES* | L 62-64 | 5-9 | D. Holden 13 | D. Yearwood 3 | E. Hammond 9 |
| January 9, 2043 | @ UTSA Roadrunners* | L 74-84 | 5-10 | D. Arthurs 12 | V. Landry 3 | E. Hammond 10 |
| January 12, 2043 | @ Charlotte 49ers* | L 57-69 | 5-11 | D. Holden 18 | D. Quezada 4 | E. Hammond 10 |
| January 14, 2043 | @ UAB Blazers* | L 69-84 | 5-12 | D. Holden 21 | N. Houston 5 | D. Main 8 |
| January 16, 2043 | NORTH TEXAS MEAN GREEN* | W 74-63 | 6-12 | D. Quezada 12 | N. Houston 4 | D. Main 12 |
| January 19, 2043 | @ #5 Wichita State Shockers* | L 53-74 | 6-13 | D. Quezada 10 | V. Landry 2 | E. Hammond 15 |
| January 23, 2043 | UAB BLAZERS* | L 64-72 | 6-14 | D. Quezada 19 | N. Houston 7 | D. Holden 8 |
| January 26, 2043 | @ Florida Atlantic Owls* | L 58-70 | 6-15 | D. Holden 16 | J. Charity 3 | D. Holden 10 |
| January 30, 2043 | @ South Florida Bulls* | L 80-94 | 6-16 | V. Landry 12 | V. Landry 4 | E. Hammond 9 |
| February 6, 2043 | TEMPLE OWLS* | W 76-63 | 7-16 | D. Yearwood 19 | V. Landry 6 | D. Holden 13 |
| February 9, 2043 | @ Rice Owls* | W 85-66 | 8-16 | D. Main 17 | N. Houston 5 | D. Holden 10 |
| February 13, 2043 | @ Tulane Green Wave* | L 74-83 | 8-17 | D. Quezada 25 | N. Houston 7 | E. Hammond 7 |
| February 16, 2043 | EAST CAROLINA PIRATES* | W 83-68 | 9-17 | D. Main 16 | N. Houston 3 | D. Holden 9 |
| February 20, 2043 | CHARLOTTE 49ERS* | L 92-95 OT | 9-18 | N. Houston 17 | D. Arthurs 5 | E. Hammond 9 |
| February 23, 2043 | #3 WICHITA STATE SHOCKERS* | L 73-86 | 9-19 | D. Quezada 10 | N. Houston 3 | E. Hammond 7 |
| February 27, 2043 | UTSA ROADRUNNERS* | W 95-72 | 10-19 | D. Quezada 18 | N. Houston 6 | D. Arthurs 9 |
| March 2, 2043 | @ North Texas Mean Green* | L 55-68 | 10-20 | D. Main 17 | N. Houston 3 | D. Holden 11 |
| March 7, 2043 | @ UTSA Roadrunners AAC Tournament | L 74-86 | 10-21 | D. Holden 13 | V. Landry 5 | D. Holden 9 |
