| November 16, 2042 | @ South Carolina Gamecocks | L 52-82 | 0-1 | D. Roland 11 | B. Menser 3 | K. Porter 11 |
| November 23, 2042 | UAB BLAZERS | W 84-57 | 1-1 | D. Roland 16 | B. Menser 5 | M. Yeaton 13 |
| November 25, 2042 | @ VCU Rams | L 55-74 | 1-2 | D. Roland 18 | L. Keenan 2 | M. Yeaton 9 |
| November 30, 2042 | LOYOLA MARYMOUNT LIONS | W 83-61 | 2-2 | L. Keenan 24 | B. Menser 4 | D. Roland 7 |
| December 3, 2042 | @ Colorado Buffaloes | L 70-87 | 2-3 | L. Keenan 13 | T. Sheppard 5 | L. Keenan 9 |
| December 7, 2042 | ILLINOIS STATE REDBIRDS | W 76-56 | 3-3 | K. Porter 14 | B. Menser 2 | M. Yeaton 11 |
| December 13, 2042 | @ South Dakota State Jackrabbits | W 70-52 | 4-3 | D. Roland 12 | B. Menser 5 | D. Beach 8 |
| December 21, 2042 | INCARNATE WORD CARDINALS | W 81-72 | 5-3 | L. Keenan 17 | B. Menser 7 | M. Yeaton 9 |
| December 23, 2042 | UMASS MINUTEMEN Gulf Coast Showcase | W 79-62 | 6-3 | L. Keenan 15 | B. Menser 5 | K. Porter 11 |
| December 24, 2042 | BYU COUGARS Gulf Coast Showcase | W 97-92 | 7-3 | L. Keenan 20 | B. Menser 6 | B. Menser 6 |
| December 25, 2042 | @ Kent State Golden Flashes (6-4, 1-0 Home) Gulf Coast Showcase | - | | | | |
| December 26, 2042 | MARYLAND TERRAPINS (7-3, 0-0, 1-2 Away)* | - | | | | |
| December 28, 2042 | @ Illinois Fighting Illini (7-2, 0-0, 5-0 Home)* | - | | | | |
| January 2, 2043 | USC TROJANS (8-2, 0-0, 0-2 Away)* | - | | | | |
| January 4, 2043 | RUTGERS SCARLET KNIGHTS (8-1, 0-0, 0-0 Away)* | - | | | | |
| January 9, 2043 | @ Wisconsin Badgers (5-4, 0-0, 5-2 Home)* | - | | | | |
| January 11, 2043 | @ Penn State Nittany Lions (6-3, 0-0, 5-0 Home)* | - | | | | |
| January 16, 2043 | OREGON DUCKS (4-5, 0-0, 0-2 Away)* | - | | | | |
| January 18, 2043 | @ Washington Huskies (3-6, 0-0, 3-2 Home)* | - | | | | |
| January 23, 2043 | PURDUE BOILERMAKERS (10-1, 0-0, 0-0 Away)* | - | | | | |
| January 25, 2043 | @ Indiana Hoosiers (7-4, 0-0, 3-1 Home)* | - | | | | |
| January 30, 2043 | NORTHWESTERN WILDCATS (5-6, 0-0, 1-2 Away)* | - | | | | |
| February 1, 2043 | UCLA BRUINS (5-5, 0-0, 0-1 Away)* | - | | | | |
| February 6, 2043 | @ Minnesota Golden Gophers (9-2, 0-0, 5-1 Home)* | - | | | | |
| February 8, 2043 | MICHIGAN WOLVERINES (4-5, 0-0, 0-2 Away)* | - | | | | |
| February 13, 2043 | @ Nebraska Cornhuskers (3-6, 0-0, 3-3 Home)* | - | | | | |
| February 15, 2043 | OHIO STATE BUCKEYES (4-5, 0-0, 0-1 Away)* | - | | | | |
| February 20, 2043 | @ Iowa Hawkeyes (9-1, 0-0, 4-0 Home)* | - | | | | |
| February 22, 2043 | @ Michigan Wolverines (4-5, 0-0, 4-2 Home)* | - | | | | |
| February 27, 2043 | INDIANA HOOSIERS (7-4, 0-0, 1-3 Away)* | - | | | | |
| March 1, 2043 | @ USC Trojans (8-2, 0-0, 6-0 Home)* | - | | | | |
