| November 16, 2042 | @ South Carolina Gamecocks | L 52-82 | 0-1 | D. Roland 11 | B. Menser 3 | K. Porter 11 |
| November 23, 2042 | UAB BLAZERS | W 84-57 | 1-1 | D. Roland 16 | B. Menser 5 | M. Yeaton 13 |
| November 25, 2042 | @ VCU Rams | L 55-74 | 1-2 | D. Roland 18 | L. Keenan 2 | M. Yeaton 9 |
| November 30, 2042 | LOYOLA MARYMOUNT LIONS | W 83-61 | 2-2 | L. Keenan 24 | B. Menser 4 | D. Roland 7 |
| December 3, 2042 | @ Colorado Buffaloes | L 70-87 | 2-3 | L. Keenan 13 | T. Sheppard 5 | L. Keenan 9 |
| December 7, 2042 | ILLINOIS STATE REDBIRDS | W 76-56 | 3-3 | K. Porter 14 | B. Menser 2 | M. Yeaton 11 |
| December 13, 2042 | @ South Dakota State Jackrabbits | W 70-52 | 4-3 | D. Roland 12 | B. Menser 5 | D. Beach 8 |
| December 21, 2042 | INCARNATE WORD CARDINALS | W 81-72 | 5-3 | L. Keenan 17 | B. Menser 7 | M. Yeaton 9 |
| December 23, 2042 | UMASS MINUTEMEN Gulf Coast Showcase | W 79-62 | 6-3 | L. Keenan 15 | B. Menser 5 | K. Porter 11 |
| December 24, 2042 | BYU COUGARS Gulf Coast Showcase | W 97-92 | 7-3 | L. Keenan 20 | B. Menser 6 | B. Menser 6 |
| December 25, 2042 | @ Kent State Golden Flashes Gulf Coast Showcase | W 77-62 | 8-3 | L. Keenan 23 | B. Menser 4 | K. Porter 14 |
| December 26, 2042 | #14 MARYLAND TERRAPINS* | L 83-93 | 8-4 | B. Menser 15 | D. Beach 4 | M. Yeaton 7 |
| December 28, 2042 | @ Illinois Fighting Illini* | L 59-68 | 8-5 | D. Roland 12 | B. Menser 3 | K. Porter 9 |
| January 2, 2043 | USC TROJANS* | W 85-77 | 9-5 | D. Roland 36 | B. Menser 5 | L. Keenan 6 |
| January 4, 2043 | RUTGERS SCARLET KNIGHTS* | W 84-55 | 10-5 | D. Roland 23 | D. Roland 7 | K. Porter 7 |
| January 9, 2043 | @ Wisconsin Badgers* | L 67-71 | 10-6 | L. Keenan 14 | C. Emerson 4 | K. Porter 8 |
| January 11, 2043 | @ Penn State Nittany Lions* | L 68-77 | 10-7 | M. Yeaton 13 | B. Menser 4 | M. Yeaton 7 |
| January 16, 2043 | OREGON DUCKS* | W 95-71 | 11-7 | D. Roland 18 | B. Menser 4 | L. Keenan 9 |
| January 18, 2043 | @ Washington Huskies* | L 77-84 | 11-8 | L. Keenan 12 | B. Menser 6 | K. Porter 8 |
| January 23, 2043 | #6 PURDUE BOILERMAKERS* | W 91-80 | 12-8 | D. Roland 25 | B. Menser 6 | K. Porter 8 |
| January 25, 2043 | @ Indiana Hoosiers* | L 72-99 | 12-9 | D. Roland 22 | E. Palacios 5 | M. Yeaton 9 |
| January 30, 2043 | NORTHWESTERN WILDCATS* | W 72-60 | 13-9 | D. Roland 18 | B. Menser 10 | K. Porter 11 |
| February 1, 2043 | UCLA BRUINS* | W 84-60 | 14-9 | D. Roland 17 | C. Emerson 4 | C. Emerson 9 |
| February 6, 2043 | @ #5 Minnesota Golden Gophers* | L 73-92 | 14-10 | K. Porter 16 | B. Menser 6 | D. Beach 9 |
| February 8, 2043 | MICHIGAN WOLVERINES* | W 70-67 | 15-10 | D. Roland 13 | B. Menser 7 | B. Menser 6 |
| February 13, 2043 | @ Nebraska Cornhuskers* | W 83-78 | 16-10 | L. Keenan 16 | B. Menser 6 | K. Porter 8 |
| February 15, 2043 | OHIO STATE BUCKEYES* | W 59-42 | 17-10 | B. Menser 15 | B. Menser 4 | K. Porter 9 |
| February 20, 2043 | @ #17 Iowa Hawkeyes* | L 61-68 | 17-11 | B. Menser 12 | B. Menser 7 | L. Keenan 6 |
| February 22, 2043 | @ Michigan Wolverines* | W 76-66 | 18-11 | L. Keenan 21 | B. Menser 8 | M. Yeaton 11 |
| February 27, 2043 | INDIANA HOOSIERS* | W 78-69 | 19-11 | M. Andersen 16 | B. Menser 6 | M. Yeaton 8 |
| March 1, 2043 | @ #25 USC Trojans* | W 87-85 | 20-11 | L. Keenan 23 | B. Menser 7 | C. Emerson 8 |
| March 9, 2043 | #23 MARYLAND TERRAPINS Big 10 Tournament | L 87-95 | 20-12 | L. Keenan 26 | B. Menser 4 | M. Yeaton 6 |
| March 17, 2043 | @ Vanderbilt Commodores NCAA Tournament | W 103-86 | 21-12 | D. Roland 25 | L. Keenan 7 | C. Emerson 7 |
| March 19, 2043 | @ #2 Baylor Bears NCAA Tournament | L 69-79 | 21-13 | D. Roland 15 | B. Menser 6 | K. Porter 9 |
