| November 16, 2042 | @ UAB Blazers | W 62-51 | 1-0 | K. Hickerson 13 | K. Hickerson 2 | B. Pryor 13 |
| November 17, 2042 | FDU KNIGHTS | W 74-65 | 2-0 | B. Pryor 20 | L. Humphries 6 | B. Pryor 11 |
| November 21, 2042 | ILLINOIS STATE REDBIRDS WSSN Classic | W 91-73 | 3-0 | B. Pryor 17 | L. Humphries 5 | B. Pryor 11 |
| November 22, 2042 | #22 UCLA BRUINS WSSN Classic | W 94-66 | 4-0 | L. Humphries 19 | L. Humphries 8 | B. Pryor 12 |
| November 23, 2042 | @ Creighton Blue Jays WSSN Classic | L 60-69 | 4-1 | B. Woods 14 | L. Humphries 5 | B. Pryor 9 |
| November 26, 2042 | DENVER PIONEERS | W 71-49 | 5-1 | K. Hickerson 15 | L. Humphries 4 | B. Pryor 12 |
| November 30, 2042 | #9 MARYLAND TERRAPINS | W 88-77 | 6-1 | B. Pryor 21 | L. Humphries 7 | B. Pryor 9 |
| December 3, 2042 | @ Temple Owls | W 84-69 | 7-1 | O. Riley 17 | L. Humphries 9 | B. Pryor 11 |
| December 7, 2042 | FURMAN PALADINS | W 75-55 | 8-1 | B. Woods 18 | L. Humphries 6 | O. Riley 8 |
| December 13, 2042 | @ #12 LSU Tigers | L 75-78 | 8-2 | L. Humphries 21 | L. Humphries 5 | B. Pryor 6 |
| December 21, 2042 | NORTH CAROLINA CENTRAL EAGLES | W 66-61 | 9-2 | O. Riley 22 | L. Humphries 3 | A. Flores 7 |
| December 26, 2042 | @ Virginia Cavaliers (2-7, 0-0, 1-2 Home)* | - | | | | |
| December 28, 2042 | GEORGIA TECH YELLOW JACKETS (8-3, 0-0, 2-2 Away)* | - | | | | |
| January 2, 2043 | NC STATE WOLFPACK (6-3, 0-0, 0-2 Away)* | - | | | | |
| January 4, 2043 | @ California Golden Bears (1-8, 0-0, 1-4 Home)* | - | | | | |
| January 9, 2043 | @ Pittsburgh Panthers (7-4, 0-0, 4-1 Home)* | - | | | | |
| January 11, 2043 | @ Louisville Cardinals (9-2, 0-0, 4-1 Home)* | - | | | | |
| January 16, 2043 | VIRGINIA TECH HOKIES (4-6, 0-0, 0-2 Away)* | - | | | | |
| January 18, 2043 | @ SMU Mustangs (6-4, 0-0, 5-2 Home)* | - | | | | |
| January 23, 2043 | NOTRE DAME FIGHTING IRISH (8-4, 0-0, 0-3 Away)* | - | | | | |
| January 25, 2043 | SYRACUSE ORANGE (6-3, 0-0, 1-1 Away)* | - | | | | |
| January 30, 2043 | @ North Carolina Tar Heels (10-1, 0-0, 5-0 Home)* | - | | | | |
| February 1, 2043 | WAKE FOREST DEMON DEACONS (3-7, 0-0, 2-3 Away)* | - | | | | |
| February 6, 2043 | CLEMSON TIGERS (2-7, 0-0, 1-3 Away)* | - | | | | |
| February 8, 2043 | BOSTON COLLEGE EAGLES (3-6, 0-0, 1-2 Away)* | - | | | | |
| February 13, 2043 | @ Duke Blue Devils (5-4, 0-0, 4-1 Home)* | - | | | | |
| February 15, 2043 | STANFORD CARDINAL (11-1, 0-0, 1-1 Away)* | - | | | | |
| February 20, 2043 | @ Florida State Seminoles (7-2, 0-0, 7-0 Home)* | - | | | | |
| February 22, 2043 | @ Boston College Eagles (3-6, 0-0, 2-3 Home)* | - | | | | |
| February 27, 2043 | @ Syracuse Orange (6-3, 0-0, 5-1 Home)* | - | | | | |
| March 1, 2043 | DUKE BLUE DEVILS (5-4, 0-0, 1-2 Away)* | - | | | | |
