| November 16, 2042 | @ UAB Blazers | W 62-51 | 1-0 | K. Hickerson 13 | K. Hickerson 2 | B. Pryor 13 |
| November 17, 2042 | FDU KNIGHTS | W 74-65 | 2-0 | B. Pryor 20 | L. Humphries 6 | B. Pryor 11 |
| November 21, 2042 | ILLINOIS STATE REDBIRDS WSSN Classic | W 91-73 | 3-0 | B. Pryor 17 | L. Humphries 5 | B. Pryor 11 |
| November 22, 2042 | #22 UCLA BRUINS WSSN Classic | W 94-66 | 4-0 | L. Humphries 19 | L. Humphries 8 | B. Pryor 12 |
| November 23, 2042 | @ Creighton Blue Jays WSSN Classic | L 60-69 | 4-1 | B. Woods 14 | L. Humphries 5 | B. Pryor 9 |
| November 26, 2042 | DENVER PIONEERS | W 71-49 | 5-1 | K. Hickerson 15 | L. Humphries 4 | B. Pryor 12 |
| November 30, 2042 | #9 MARYLAND TERRAPINS | W 88-77 | 6-1 | B. Pryor 21 | L. Humphries 7 | B. Pryor 9 |
| December 3, 2042 | @ Temple Owls | W 84-69 | 7-1 | O. Riley 17 | L. Humphries 9 | B. Pryor 11 |
| December 7, 2042 | FURMAN PALADINS | W 75-55 | 8-1 | B. Woods 18 | L. Humphries 6 | O. Riley 8 |
| December 13, 2042 | @ #12 LSU Tigers | L 75-78 | 8-2 | L. Humphries 21 | L. Humphries 5 | B. Pryor 6 |
| December 21, 2042 | NORTH CAROLINA CENTRAL EAGLES | W 66-61 | 9-2 | O. Riley 22 | L. Humphries 3 | A. Flores 7 |
| December 26, 2042 | @ Virginia Cavaliers* | L 72-82 | 9-3 | B. Woods 14 | L. Humphries 6 | B. Woods 8 |
| December 28, 2042 | GEORGIA TECH YELLOW JACKETS* | W 82-67 | 10-3 | B. Woods 21 | K. Hickerson 3 | A. Flores 8 |
| January 2, 2043 | NC STATE WOLFPACK* | W 71-60 | 11-3 | K. Hickerson 17 | L. Humphries 6 | B. Pryor 8 |
| January 4, 2043 | @ California Golden Bears* | L 74-76 OT | 11-4 | B. Woods 18 | L. Humphries 3 | A. Flores 11 |
| January 9, 2043 | @ Pittsburgh Panthers* | L 66-67 | 11-5 | B. Woods 18 | B. Woods 4 | B. Woods 11 |
| January 11, 2043 | @ #16 Louisville Cardinals* | L 68-80 | 11-6 | L. Humphries 13 | L. Humphries 5 | B. Pryor 7 |
| January 16, 2043 | VIRGINIA TECH HOKIES* | W 69-51 | 12-6 | B. Woods 18 | L. Humphries 5 | B. Pryor 16 |
| January 18, 2043 | @ SMU Mustangs* | L 71-83 | 12-7 | K. Hickerson 19 | L. Humphries 6 | B. Woods 7 |
| January 23, 2043 | #13 NOTRE DAME FIGHTING IRISH* | W 79-75 | 13-7 | L. Humphries 16 | B. Woods 6 | B. Pryor 11 |
| January 25, 2043 | SYRACUSE ORANGE* | L 69-76 | 13-8 | K. Hickerson 21 | L. Humphries 5 | O. Riley 7 |
| January 30, 2043 | @ #1 North Carolina Tar Heels* | L 56-74 | 13-9 | B. Pryor 14 | L. Humphries 4 | B. Pryor 18 |
| February 1, 2043 | WAKE FOREST DEMON DEACONS* | W 74-61 | 14-9 | B. Woods 17 | L. Humphries 3 | B. Pryor 17 |
| February 6, 2043 | CLEMSON TIGERS* | W 87-65 | 15-9 | L. Humphries 14 | O. Riley 6 | B. Pryor 11 |
| February 8, 2043 | BOSTON COLLEGE EAGLES* | W 95-74 | 16-9 | L. Humphries 21 | L. Humphries 8 | B. Pryor 10 |
| February 13, 2043 | @ Duke Blue Devils (13-10, 8-6, 8-3 Home)* | - | | | | |
| February 15, 2043 | STANFORD CARDINAL (20-6, 9-5, 5-4 Away)* | - | | | | |
| February 20, 2043 | @ Florida State Seminoles (14-9, 7-7, 11-2 Home)* | - | | | | |
| February 22, 2043 | @ Boston College Eagles (7-16, 4-10, 5-7 Home)* | - | | | | |
| February 27, 2043 | @ Syracuse Orange (13-10, 7-7, 7-4 Home)* | - | | | | |
| March 1, 2043 | DUKE BLUE DEVILS (13-10, 8-6, 5-6 Away)* | - | | | | |
