| November 15, 2042 | @ Alabama Crimson Tide | L 60-102 | 0-1 | D. Caldwell 11 | L. Akers 3 | H. Perry 4 |
| November 22, 2042 | @ Holy Cross Crusaders | L 73-74 | 0-2 | D. Moya 16 | J. Calderon 5 | L. Akers 7 |
| November 25, 2042 | MAINE BLACK BEARS | W 80-73 | 1-2 | J. Calderon 17 | D. Moya 3 | J. Calderon 5 |
| November 29, 2042 | RICHMOND SPIDERS | W 81-54 | 2-2 | J. Calderon 19 | D. Moya 7 | D. Caldwell 10 |
| December 2, 2042 | DETROIT MERCY TITANS | L 71-72 | 2-3 | D. Moya 13 | D. Moya 3 | D. Caldwell 7 |
| December 6, 2042 | @ Texas A&M Aggies | L 69-74 | 2-4 | J. Calderon 23 | L. Akers 5 | L. Akers 6 |
| December 9, 2042 | @ Indiana Hoosiers Cayman Islands Classic | L 61-79 | 2-5 | H. Perry 12 | D. Moya 3 | L. Akers 9 |
| December 13, 2042 | NORTHERN KENTUCKY NORSE | W 78-50 | 3-5 | D. Moya 12 | L. Akers 4 | D. Carter 14 |
| December 15, 2042 | @ MD-Eastern Shore Hawks | L 65-79 | 3-6 | D. Moya 19 | J. Calderon 5 | L. Akers 6 |
| December 26, 2042 | KENT STATE GOLDEN FLASHES (6-4, 0-0, 3-4 Away)* | - | | | | |
| December 29, 2042 | BOWLING GREEN FALCONS (3-6, 0-0, 0-6 Away)* | - | | | | |
| January 2, 2043 | @ Eastern Michigan Eagles (5-4, 0-0, 2-1 Home)* | - | | | | |
| January 5, 2043 | @ Toledo Rockets (5-5, 0-0, 3-0 Home)* | - | | | | |
| January 9, 2043 | @ Akron Zips (7-2, 0-0, 4-0 Home)* | - | | | | |
| January 12, 2043 | WESTERN MICHIGAN BRONCOS (5-4, 0-0, 2-2 Away)* | - | | | | |
| January 16, 2043 | @ Ball State Cardinals (2-7, 0-0, 1-2 Home)* | - | | | | |
| January 19, 2043 | CENTRAL MICHIGAN CHIPPEWAS (4-5, 0-0, 1-5 Away)* | - | | | | |
| January 23, 2043 | NORTHERN ILLINOIS HUSKIES (6-3, 0-0, 1-3 Away)* | - | | | | |
| January 26, 2043 | BALL STATE CARDINALS (2-7, 0-0, 1-5 Away)* | - | | | | |
| January 30, 2043 | @ Central Michigan Chippewas (4-5, 0-0, 3-0 Home)* | - | | | | |
| February 2, 2043 | @ Northern Illinois Huskies (6-3, 0-0, 5-0 Home)* | - | | | | |
| February 6, 2043 | @ Western Michigan Broncos (5-4, 0-0, 3-2 Home)* | - | | | | |
| February 9, 2043 | @ Buffalo Bulls (4-5, 0-0, 4-0 Home)* | - | | | | |
| February 13, 2043 | EASTERN MICHIGAN EAGLES (5-4, 0-0, 3-3 Away)* | - | | | | |
| February 16, 2043 | TOLEDO ROCKETS (5-5, 0-0, 1-4 Away)* | - | | | | |
| February 20, 2043 | @ Kent State Golden Flashes (6-4, 0-0, 1-0 Home)* | - | | | | |
| February 23, 2043 | @ Bowling Green Falcons (3-6, 0-0, 3-0 Home)* | - | | | | |
| February 27, 2043 | BUFFALO BULLS (4-5, 0-0, 0-4 Away)* | - | | | | |
| March 2, 2043 | OHIO BOBCATS (6-4, 0-0, 0-2 Away)* | - | | | | |
