| November 13, 2042 | FURMAN PALADINS Legends Classic | W 88-66 | 1-0 | J. Casillas 21 | J. Casillas 4 | L. Mann 12 |
| November 15, 2042 | OHIO BOBCATS Legends Classic | W 85-83 | 2-0 | D. Reyes 16 | J. Casillas 8 | D. Taylor 9 |
| November 17, 2042 | #24 STANFORD CARDINAL Legends Classic | L 81-99 | 2-1 | D. Reyes 19 | J. Casillas 6 | L. Mann 6 |
| November 23, 2042 | @ Kansas State Wildcats | W 81-70 | 3-1 | L. Mann 21 | J. Casillas 3 | L. Mann 8 |
| November 26, 2042 | COLORADO STATE RAMS | W 90-74 | 4-1 | J. Casillas 19 | J. Casillas 3 | L. Mann 14 |
| November 30, 2042 | #6 WEST VIRGINIA MOUNTAINEERS | W 91-75 | 5-1 | D. Reyes 17 | J. Casillas 6 | L. Mann 10 |
| December 3, 2042 | #4 NOTRE DAME FIGHTING IRISH | W 75-72 | 6-1 | L. Mann 24 | J. Casillas 8 | L. Mann 12 |
| December 7, 2042 | VIRGINIA TECH HOKIES | W 73-64 | 7-1 | J. Casillas 18 | J. Casillas 5 | L. Mann 14 |
| December 10, 2042 | IOWA STATE CYCLONES | W 79-62 | 8-1 | L. Mann 19 | J. Casillas 5 | L. Mann 15 |
| December 13, 2042 | @ St. Thomas Tommies | W 81-78 | 9-1 | L. Mann 15 | J. Casillas 4 | L. Mann 10 |
| December 21, 2042 | FLORIDA GATORS | L 81-84 | 9-2 | L. Mann 29 | J. Casillas 8 | L. Mann 12 |
| December 26, 2042 | WISCONSIN BADGERS* | W 87-40 | 10-2 | K. Stinnett 20 | A. Kalmari 8 | K. Stinnett 10 |
| December 28, 2042 | @ Washington Huskies* | W 102-84 | 11-2 | D. Reyes 21 | J. Casillas 5 | L. Mann 8 |
| January 2, 2043 | @ #19 Iowa Hawkeyes* | W 74-67 | 12-2 | L. Mann 19 | D. Reyes 4 | L. Mann 10 |
| January 4, 2043 | USC TROJANS* | L 82-89 | 12-3 | D. Reyes 15 | J. Casillas 8 | D. Taylor 9 |
| January 9, 2043 | RUTGERS SCARLET KNIGHTS* | W 80-51 | 13-3 | K. Stinnett 16 | J. Casillas 8 | D. Taylor 12 |
| January 11, 2043 | ILLINOIS FIGHTING ILLINI* | W 84-73 | 14-3 | J. Casillas 23 | J. Casillas 6 | D. Taylor 12 |
| January 16, 2043 | UCLA BRUINS* | W 81-72 | 15-3 | E. Augusto 27 | J. Casillas 9 | D. Taylor 10 |
| January 18, 2043 | @ Oregon Ducks* | W 78-75 OT | 16-3 | E. Augusto 24 | J. Casillas 4 | J. Bass 11 |
| January 23, 2043 | OHIO STATE BUCKEYES* | W 96-73 | 17-3 | D. Reyes 33 | J. Casillas 9 | D. Taylor 10 |
| January 25, 2043 | @ #6 Purdue Boilermakers* | L 69-85 | 17-4 | K. Stinnett 16 | J. Casillas 6 | K. Stinnett 8 |
| January 30, 2043 | MICHIGAN WOLVERINES* | W 81-67 | 18-4 | J. Bass 19 | J. Casillas 6 | J. Bass 8 |
| February 1, 2043 | @ Nebraska Cornhuskers* | W 86-77 | 19-4 | J. Casillas 22 | J. Casillas 7 | D. Taylor 11 |
| February 6, 2043 | MICHIGAN STATE SPARTANS* | W 92-73 | 20-4 | D. Taylor 18 | J. Casillas 5 | D. Taylor 9 |
| February 8, 2043 | @ Northwestern Wildcats* | W 76-70 | 21-4 | E. Augusto 17 | J. Casillas 3 | D. Taylor 14 |
| February 13, 2043 | @ Indiana Hoosiers (17-8, 10-4, 9-2 Home)* | - | | | | |
| February 15, 2043 | @ Maryland Terrapins (16-8, 9-5, 9-2 Home)* | - | | | | |
| February 20, 2043 | @ Penn State Nittany Lions (18-5, 12-2, 10-1 Home)* | - | | | | |
| February 22, 2043 | NORTHWESTERN WILDCATS (12-13, 7-7, 4-6 Away)* | - | | | | |
| February 27, 2043 | @ USC Trojans (16-9, 8-6, 11-1 Home)* | - | | | | |
| March 1, 2043 | NEBRASKA CORNHUSKERS (5-18, 2-12, 0-8 Away)* | - | | | | |
