| November 16, 2042 | UCF KNIGHTS | W 74-58 | 1-0 | R. Kelly 12 | R. Kelly 4 | D. Valencia 13 |
| November 19, 2042 | RHODE ISLAND RAMS | W 88-77 | 2-0 | D. Valencia 25 | R. Kelly 7 | D. Valencia 16 |
| November 23, 2042 | KENT STATE GOLDEN FLASHES | W 76-64 | 3-0 | O. Arndt 14 | K. Walker 8 | O. Arndt 10 |
| November 26, 2042 | @ #25 Xavier Musketeers | L 71-79 | 3-1 | R. Kelly 16 | K. Walker 6 | R. Kelly 8 |
| November 30, 2042 | TOLEDO ROCKETS | W 69-55 | 4-1 | K. Walker 24 | R. Kelly 2 | D. Valencia 10 |
| December 7, 2042 | ST. JOHN'S RED STORM | W 75-55 | 5-1 | E. Wyatt 22 | K. Walker 8 | E. Wyatt 10 |
| December 13, 2042 | @ #22 Ole Miss Rebels | L 66-85 | 5-2 | R. Kelly 20 | K. Walker 10 | E. Wyatt 8 |
| December 16, 2042 | SOUTH FLORIDA BULLS Vegas Showdown | L 52-70 | 5-3 | K. Walker 10 | K. Walker 3 | T. Rankin 8 |
| December 21, 2042 | NORFOLK STATE SPARTANS | W 72-58 | 6-3 | R. Kelly 10 | K. Walker 6 | O. Arndt 9 |
| December 26, 2042 | NOTRE DAME FIGHTING IRISH (8-4, 0-0, 0-3 Away)* | - | | | | |
| December 28, 2042 | VIRGINIA TECH HOKIES (4-6, 0-0, 0-2 Away)* | - | | | | |
| January 2, 2043 | @ Miami (FL) Hurricanes (9-2, 0-0, 5-0 Home)* | - | | | | |
| January 4, 2043 | SMU MUSTANGS (6-4, 0-0, 0-1 Away)* | - | | | | |
| January 9, 2043 | @ Wake Forest Demon Deacons (3-7, 0-0, 0-3 Home)* | - | | | | |
| January 11, 2043 | @ North Carolina Tar Heels (10-1, 0-0, 5-0 Home)* | - | | | | |
| January 16, 2043 | @ Boston College Eagles (3-6, 0-0, 2-3 Home)* | - | | | | |
| January 18, 2043 | VIRGINIA CAVALIERS (2-7, 0-0, 1-4 Away)* | - | | | | |
| January 23, 2043 | STANFORD CARDINAL (11-1, 0-0, 1-1 Away)* | - | | | | |
| January 25, 2043 | @ Pittsburgh Panthers (7-4, 0-0, 4-1 Home)* | - | | | | |
| January 30, 2043 | @ Clemson Tigers (2-7, 0-0, 1-3 Home)* | - | | | | |
| February 1, 2043 | LOUISVILLE CARDINALS (9-2, 0-0, 3-0 Away)* | - | | | | |
| February 6, 2043 | CALIFORNIA GOLDEN BEARS (1-8, 0-0, 0-3 Away)* | - | | | | |
| February 8, 2043 | FLORIDA STATE SEMINOLES (7-2, 0-0, 0-2 Away)* | - | | | | |
| February 13, 2043 | GEORGIA TECH YELLOW JACKETS (8-3, 0-0, 2-2 Away)* | - | | | | |
| February 15, 2043 | @ Syracuse Orange (6-3, 0-0, 5-1 Home)* | - | | | | |
| February 20, 2043 | @ Duke Blue Devils (5-4, 0-0, 4-1 Home)* | - | | | | |
| February 22, 2043 | @ SMU Mustangs (6-4, 0-0, 5-2 Home)* | - | | | | |
| February 27, 2043 | PITTSBURGH PANTHERS (7-4, 0-0, 0-3 Away)* | - | | | | |
| March 1, 2043 | @ Louisville Cardinals (9-2, 0-0, 4-1 Home)* | - | | | | |
