| November 16, 2042 | UCF KNIGHTS | W 74-58 | 1-0 | R. Kelly 12 | R. Kelly 4 | D. Valencia 13 |
| November 19, 2042 | RHODE ISLAND RAMS | W 88-77 | 2-0 | D. Valencia 25 | R. Kelly 7 | D. Valencia 16 |
| November 23, 2042 | KENT STATE GOLDEN FLASHES | W 76-64 | 3-0 | O. Arndt 14 | K. Walker 8 | O. Arndt 10 |
| November 26, 2042 | @ #25 Xavier Musketeers | L 71-79 | 3-1 | R. Kelly 16 | K. Walker 6 | R. Kelly 8 |
| November 30, 2042 | TOLEDO ROCKETS | W 69-55 | 4-1 | K. Walker 24 | R. Kelly 2 | D. Valencia 10 |
| December 7, 2042 | ST. JOHN'S RED STORM | W 75-55 | 5-1 | E. Wyatt 22 | K. Walker 8 | E. Wyatt 10 |
| December 13, 2042 | @ #22 Ole Miss Rebels | L 66-85 | 5-2 | R. Kelly 20 | K. Walker 10 | E. Wyatt 8 |
| December 16, 2042 | SOUTH FLORIDA BULLS Vegas Showdown | L 52-70 | 5-3 | K. Walker 10 | K. Walker 3 | T. Rankin 8 |
| December 21, 2042 | NORFOLK STATE SPARTANS | W 72-58 | 6-3 | R. Kelly 10 | K. Walker 6 | O. Arndt 9 |
| December 26, 2042 | #15 NOTRE DAME FIGHTING IRISH* | L 62-75 | 6-4 | K. Walker 12 | K. Walker 5 | E. Wyatt 9 |
| December 28, 2042 | VIRGINIA TECH HOKIES* | W 74-58 | 7-4 | D. Valencia 18 | R. Kelly 5 | E. Wyatt 12 |
| January 2, 2043 | @ #21 Miami (FL) Hurricanes* | L 60-71 | 7-5 | O. Arndt 13 | K. Walker 3 | O. Arndt 6 |
| January 4, 2043 | SMU MUSTANGS* | L 68-74 | 7-6 | J. Hackett 14 | K. Walker 5 | E. Wyatt 7 |
| January 9, 2043 | @ Wake Forest Demon Deacons* | L 59-69 | 7-7 | O. Arndt 11 | K. Walker 6 | O. Arndt 9 |
| January 11, 2043 | @ #2 North Carolina Tar Heels* | L 46-72 | 7-8 | K. Walker 12 | K. Walker 3 | E. Wyatt 10 |
| January 16, 2043 | @ Boston College Eagles* | W 75-69 | 8-8 | D. Valencia 25 | K. Walker 9 | J. Hackett 7 |
| January 18, 2043 | VIRGINIA CAVALIERS* | W 53-46 | 9-8 | O. Arndt 11 | K. Walker 3 | D. Valencia 10 |
| January 23, 2043 | #7 STANFORD CARDINAL* | W 71-60 | 10-8 | K. Cabrera 12 | K. Walker 4 | D. Valencia 12 |
| January 25, 2043 | @ Pittsburgh Panthers* | W 79-73 | 11-8 | K. Walker 21 | O. Arndt 3 | D. Valencia 10 |
| January 30, 2043 | @ Clemson Tigers* | W 72-59 | 12-8 | K. Walker 16 | K. Walker 6 | O. Arndt 9 |
| February 1, 2043 | LOUISVILLE CARDINALS* | W 76-62 | 13-8 | O. Arndt 15 | K. Walker 8 | E. Wyatt 9 |
| February 6, 2043 | CALIFORNIA GOLDEN BEARS* | W 96-71 | 14-8 | J. Hackett 22 | J. Hackett 6 | D. Valencia 10 |
| February 8, 2043 | FLORIDA STATE SEMINOLES* | W 83-74 | 15-8 | J. Hackett 19 | K. Walker 5 | E. Wyatt 7 |
| February 13, 2043 | GEORGIA TECH YELLOW JACKETS (16-9, 8-6, 4-6 Away)* | - | | | | |
| February 15, 2043 | @ Syracuse Orange (13-10, 7-7, 7-4 Home)* | - | | | | |
| February 20, 2043 | @ Duke Blue Devils (13-10, 8-6, 8-3 Home)* | - | | | | |
| February 22, 2043 | @ SMU Mustangs (13-11, 7-7, 9-4 Home)* | - | | | | |
| February 27, 2043 | PITTSBURGH PANTHERS (15-10, 8-6, 3-6 Away)* | - | | | | |
| March 1, 2043 | @ Louisville Cardinals (15-10, 6-8, 9-4 Home)* | - | | | | |
