| November 16, 2042 | ST. THOMAS TOMMIES | W 76-73 | 1-0 | B. Robisch 27 | S. Przybilla 5 | S. Przybilla 10 |
| November 18, 2042 | BELMONT BRUINS Emerald Coast Classic | L 64-75 | 1-1 | K. Samson 15 | G. Ransom 4 | J. Breen 10 |
| November 23, 2042 | GEORGIA SOUTHERN EAGLES | L 91-105 | 1-2 | B. Robisch 24 | G. Ransom 7 | S. Przybilla 8 |
| November 26, 2042 | CLEMSON TIGERS | L 64-71 | 1-3 | B. Robisch 17 | S. Przybilla 5 | J. Breen 10 |
| November 28, 2042 | @ #19 Gonzaga Bulldogs | L 55-78 | 1-4 | B. Robisch 9 | S. Przybilla 2 | T. Talbert 8 |
| December 2, 2042 | MISSOURI TIGERS | W 96-80 | 2-4 | S. Przybilla 24 | G. Ransom 8 | J. Breen 11 |
| December 9, 2042 | NJIT HIGHLANDERS | W 76-67 | 3-4 | G. Ransom 16 | G. Ransom 11 | J. Breen 7 |
| December 13, 2042 | #13 CREIGHTON BLUE JAYS | L 75-84 | 3-5 | B. Robisch 20 | K. Samson 5 | T. Talbert 6 |
| December 19, 2042 | @ #20 Saint Mary's Gaels | L 43-61 | 3-6 | J. Breen 10 | S. Przybilla 4 | T. Talbert 7 |
| December 26, 2042 | USC TROJANS (8-2, 0-0, 0-2 Away)* | - | | | | |
| December 28, 2042 | MARYLAND TERRAPINS (7-3, 0-0, 1-2 Away)* | - | | | | |
| January 2, 2043 | @ Illinois Fighting Illini (7-2, 0-0, 5-0 Home)* | - | | | | |
| January 4, 2043 | PENN STATE NITTANY LIONS (6-3, 0-0, 1-2 Away)* | - | | | | |
| January 9, 2043 | @ Iowa Hawkeyes (9-1, 0-0, 4-0 Home)* | - | | | | |
| January 11, 2043 | @ Ohio State Buckeyes (4-5, 0-0, 4-3 Home)* | - | | | | |
| January 16, 2043 | @ Wisconsin Badgers (5-4, 0-0, 5-2 Home)* | - | | | | |
| January 18, 2043 | NORTHWESTERN WILDCATS (5-6, 0-0, 1-2 Away)* | - | | | | |
| January 23, 2043 | UCLA BRUINS (5-5, 0-0, 0-1 Away)* | - | | | | |
| January 25, 2043 | @ Oregon Ducks (4-5, 0-0, 4-2 Home)* | - | | | | |
| January 30, 2043 | @ Indiana Hoosiers (7-4, 0-0, 3-1 Home)* | - | | | | |
| February 1, 2043 | MINNESOTA GOLDEN GOPHERS (9-2, 0-0, 2-0 Away)* | - | | | | |
| February 6, 2043 | MICHIGAN WOLVERINES (4-5, 0-0, 0-2 Away)* | - | | | | |
| February 8, 2043 | PURDUE BOILERMAKERS (10-1, 0-0, 0-0 Away)* | - | | | | |
| February 13, 2043 | MICHIGAN STATE SPARTANS (7-3, 0-0, 1-3 Away)* | - | | | | |
| February 15, 2043 | @ Rutgers Scarlet Knights (8-1, 0-0, 8-0 Home)* | - | | | | |
| February 20, 2043 | @ Washington Huskies (3-6, 0-0, 3-2 Home)* | - | | | | |
| February 22, 2043 | @ Penn State Nittany Lions (6-3, 0-0, 5-0 Home)* | - | | | | |
| February 27, 2043 | OREGON DUCKS (4-5, 0-0, 0-2 Away)* | - | | | | |
| March 1, 2043 | @ Minnesota Golden Gophers (9-2, 0-0, 5-1 Home)* | - | | | | |
