| November 16, 2042 | ST. THOMAS TOMMIES | W 76-73 | 1-0 | B. Robisch 27 | S. Przybilla 5 | S. Przybilla 10 |
| November 18, 2042 | BELMONT BRUINS Emerald Coast Classic | L 64-75 | 1-1 | K. Samson 15 | G. Ransom 4 | J. Breen 10 |
| November 23, 2042 | GEORGIA SOUTHERN EAGLES | L 91-105 | 1-2 | B. Robisch 24 | G. Ransom 7 | S. Przybilla 8 |
| November 26, 2042 | CLEMSON TIGERS | L 64-71 | 1-3 | B. Robisch 17 | S. Przybilla 5 | J. Breen 10 |
| November 28, 2042 | @ #19 Gonzaga Bulldogs | L 55-78 | 1-4 | B. Robisch 9 | S. Przybilla 2 | T. Talbert 8 |
| December 2, 2042 | MISSOURI TIGERS | W 96-80 | 2-4 | S. Przybilla 24 | G. Ransom 8 | J. Breen 11 |
| December 9, 2042 | NJIT HIGHLANDERS | W 76-67 | 3-4 | G. Ransom 16 | G. Ransom 11 | J. Breen 7 |
| December 13, 2042 | #13 CREIGHTON BLUE JAYS | L 75-84 | 3-5 | B. Robisch 20 | K. Samson 5 | T. Talbert 6 |
| December 19, 2042 | @ #20 Saint Mary's Gaels | L 43-61 | 3-6 | J. Breen 10 | S. Przybilla 4 | T. Talbert 7 |
| December 26, 2042 | USC TROJANS* | W 90-78 | 4-6 | L. Hines 17 | G. Ransom 4 | L. Hines 10 |
| December 28, 2042 | #14 MARYLAND TERRAPINS* | L 63-74 | 4-7 | G. Ransom 15 | G. Ransom 4 | K. Samson 7 |
| January 2, 2043 | @ Illinois Fighting Illini* | L 58-75 | 4-8 | J. Breen 24 | G. Ransom 3 | B. Robisch 8 |
| January 4, 2043 | PENN STATE NITTANY LIONS* | L 83-92 | 4-9 | B. Robisch 19 | G. Ransom 4 | G. Ransom 6 |
| January 9, 2043 | @ #19 Iowa Hawkeyes* | L 58-76 | 4-10 | J. Breen 11 | G. Ransom 4 | K. Samson 6 |
| January 11, 2043 | @ Ohio State Buckeyes* | L 62-79 | 4-11 | B. Robisch 18 | G. Ransom 4 | T. Talbert 8 |
| January 16, 2043 | @ Wisconsin Badgers* | L 81-85 | 4-12 | B. Robisch 22 | G. Ransom 6 | S. Przybilla 8 |
| January 18, 2043 | NORTHWESTERN WILDCATS* | L 81-83 | 4-13 | G. Ransom 15 | G. Ransom 3 | L. Hines 5 |
| January 23, 2043 | UCLA BRUINS* | W 83-73 | 5-13 | G. Ransom 20 | J. Breen 5 | K. Samson 9 |
| January 25, 2043 | @ Oregon Ducks* | L 75-86 | 5-14 | B. Robisch 15 | G. Ransom 5 | S. Przybilla 7 |
| January 30, 2043 | @ Indiana Hoosiers* | L 61-83 | 5-15 | J. Breen 11 | V. King 3 | J. Breen 10 |
| February 1, 2043 | #5 MINNESOTA GOLDEN GOPHERS* | L 77-86 | 5-16 | G. Ransom 15 | G. Ransom 5 | B. Robisch 7 |
| February 6, 2043 | MICHIGAN WOLVERINES* | L 52-77 | 5-17 | L. Hines 13 | S. Przybilla 2 | L. Hines 6 |
| February 8, 2043 | #8 PURDUE BOILERMAKERS* | L 80-92 | 5-18 | S. Przybilla 19 | G. Ransom 7 | B. Robisch 7 |
| February 13, 2043 | MICHIGAN STATE SPARTANS (15-10, 7-7, 1-9 Away)* | - | | | | |
| February 15, 2043 | @ Rutgers Scarlet Knights (11-12, 3-11, 10-3 Home)* | - | | | | |
| February 20, 2043 | @ Washington Huskies (5-18, 2-12, 5-6 Home)* | - | | | | |
| February 22, 2043 | @ Penn State Nittany Lions (18-5, 12-2, 10-1 Home)* | - | | | | |
| February 27, 2043 | OREGON DUCKS (13-10, 9-5, 3-5 Away)* | - | | | | |
| March 1, 2043 | @ Minnesota Golden Gophers (21-4, 12-2, 12-2 Home)* | - | | | | |
