| November 13, 2042 | LIBERTY FLAMES | L 65-68 | 0-1 | L. Horner 15 | J. Reeder 4 | D. Finley 9 |
| November 15, 2042 | LA SALLE EXPLORERS | L 53-75 | 0-2 | J. Reeder 16 | O. Sewell 4 | D. Finley 9 |
| November 22, 2042 | @ Missouri Tigers | L 66-85 | 0-3 | J. Reeder 21 | D. Finley 5 | D. Brady 7 |
| December 5, 2042 | @ BYU Cougars | L 60-75 | 0-4 | O. Sewell 13 | O. Sewell 4 | D. Finley 8 |
| December 9, 2042 | @ Dayton Flyers Jimmy V Classic | W 77-62 | 1-4 | J. Reeder 17 | D. Brady 4 | D. Brady 9 |
| December 10, 2042 | @ Arkansas Razorbacks Jimmy V Classic | W 68-56 | 2-4 | O. Sewell 22 | J. Reeder 4 | D. Brady 14 |
| December 11, 2042 | SAN JOSE STATE SPARTANS Jimmy V Classic | L 57-65 | 2-5 | O. Sewell 14 | L. Horner 6 | L. Horner 7 |
| December 13, 2042 | @ UIC Flames | W 84-66 | 3-5 | O. Sewell 19 | O. Sewell 3 | D. Finley 9 |
| December 16, 2042 | ALABAMA A&M BULLDOGS | L 70-74 | 3-6 | J. Reeder 16 | D. Brady 5 | D. Finley 8 |
| December 19, 2042 | MONTANA GRIZZLIES | W 83-59 | 4-6 | O. Sewell 15 | O. Sewell 5 | D. Brady 11 |
| December 22, 2042 | MONTANA STATE BOBCATS | W 76-68 | 5-6 | L. Horner 14 | D. Finley 4 | L. Horner 9 |
| December 26, 2042 | ILLINOIS FIGHTING ILLINI (7-2, 0-0, 2-2 Away)* | - | | | | |
| December 28, 2042 | @ USC Trojans (8-2, 0-0, 6-0 Home)* | - | | | | |
| January 2, 2043 | MARYLAND TERRAPINS (7-3, 0-0, 1-2 Away)* | - | | | | |
| January 4, 2043 | @ Ohio State Buckeyes (4-5, 0-0, 4-3 Home)* | - | | | | |
| January 9, 2043 | WASHINGTON HUSKIES (3-6, 0-0, 0-3 Away)* | - | | | | |
| January 11, 2043 | @ Rutgers Scarlet Knights (8-1, 0-0, 8-0 Home)* | - | | | | |
| January 16, 2043 | MICHIGAN WOLVERINES (4-5, 0-0, 0-2 Away)* | - | | | | |
| January 18, 2043 | @ Nebraska Cornhuskers (3-6, 0-0, 3-3 Home)* | - | | | | |
| January 23, 2043 | @ Indiana Hoosiers (7-4, 0-0, 3-1 Home)* | - | | | | |
| January 25, 2043 | @ Iowa Hawkeyes (9-1, 0-0, 4-0 Home)* | - | | | | |
| January 30, 2043 | @ Michigan State Spartans (7-3, 0-0, 4-0 Home)* | - | | | | |
| February 1, 2043 | PURDUE BOILERMAKERS (10-1, 0-0, 0-0 Away)* | - | | | | |
| February 6, 2043 | OREGON DUCKS (4-5, 0-0, 0-2 Away)* | - | | | | |
| February 8, 2043 | MINNESOTA GOLDEN GOPHERS (9-2, 0-0, 2-0 Away)* | - | | | | |
| February 13, 2043 | UCLA BRUINS (5-5, 0-0, 0-1 Away)* | - | | | | |
| February 15, 2043 | @ Penn State Nittany Lions (6-3, 0-0, 5-0 Home)* | - | | | | |
| February 20, 2043 | @ Wisconsin Badgers (5-4, 0-0, 5-2 Home)* | - | | | | |
| February 22, 2043 | @ Minnesota Golden Gophers (9-2, 0-0, 5-1 Home)* | - | | | | |
| February 27, 2043 | IOWA HAWKEYES (9-1, 0-0, 3-1 Away)* | - | | | | |
| March 1, 2043 | PENN STATE NITTANY LIONS (6-3, 0-0, 1-2 Away)* | - | | | | |
