| November 13, 2042 | LIBERTY FLAMES | L 65-68 | 0-1 | L. Horner 15 | J. Reeder 4 | D. Finley 9 |
| November 15, 2042 | LA SALLE EXPLORERS | L 53-75 | 0-2 | J. Reeder 16 | O. Sewell 4 | D. Finley 9 |
| November 22, 2042 | @ Missouri Tigers | L 66-85 | 0-3 | J. Reeder 21 | D. Finley 5 | D. Brady 7 |
| December 5, 2042 | @ BYU Cougars | L 60-75 | 0-4 | O. Sewell 13 | O. Sewell 4 | D. Finley 8 |
| December 9, 2042 | @ Dayton Flyers Jimmy V Classic | W 77-62 | 1-4 | J. Reeder 17 | D. Brady 4 | D. Brady 9 |
| December 10, 2042 | @ Arkansas Razorbacks Jimmy V Classic | W 68-56 | 2-4 | O. Sewell 22 | J. Reeder 4 | D. Brady 14 |
| December 11, 2042 | SAN JOSE STATE SPARTANS Jimmy V Classic | L 57-65 | 2-5 | O. Sewell 14 | L. Horner 6 | L. Horner 7 |
| December 13, 2042 | @ UIC Flames | W 84-66 | 3-5 | O. Sewell 19 | O. Sewell 3 | D. Finley 9 |
| December 16, 2042 | ALABAMA A&M BULLDOGS | L 70-74 | 3-6 | J. Reeder 16 | D. Brady 5 | D. Finley 8 |
| December 19, 2042 | MONTANA GRIZZLIES | W 83-59 | 4-6 | O. Sewell 15 | O. Sewell 5 | D. Brady 11 |
| December 22, 2042 | MONTANA STATE BOBCATS | W 76-68 | 5-6 | L. Horner 14 | D. Finley 4 | L. Horner 9 |
| December 26, 2042 | ILLINOIS FIGHTING ILLINI* | W 79-77 | 6-6 | J. Reeder 14 | J. Bush 5 | D. Brady 6 |
| December 28, 2042 | @ USC Trojans* | L 68-89 | 6-7 | J. Reeder 15 | O. Sewell 4 | D. Finley 11 |
| January 2, 2043 | #9 MARYLAND TERRAPINS* | L 55-57 | 6-8 | J. Reeder 12 | O. Sewell 4 | L. Horner 10 |
| January 4, 2043 | @ Ohio State Buckeyes* | W 63-50 | 7-8 | O. Sewell 22 | O. Sewell 5 | L. Horner 6 |
| January 9, 2043 | WASHINGTON HUSKIES* | W 67-60 | 8-8 | J. Reeder 16 | J. Reeder 2 | L. Horner 10 |
| January 11, 2043 | @ Rutgers Scarlet Knights* | L 70-81 | 8-9 | O. Sewell 17 | O. Sewell 6 | D. Finley 8 |
| January 16, 2043 | MICHIGAN WOLVERINES* | W 75-70 | 9-9 | J. Reeder 20 | O. Sewell 5 | D. Brady 8 |
| January 18, 2043 | @ Nebraska Cornhuskers* | W 83-81 | 10-9 | J. Bush 18 | L. Horner 5 | D. Brady 9 |
| January 23, 2043 | @ Indiana Hoosiers* | L 76-85 | 10-10 | D. Brady 14 | O. Sewell 4 | L. Horner 6 |
| January 25, 2043 | @ #16 Iowa Hawkeyes* | W 76-64 | 11-10 | J. Reeder 29 | O. Sewell 6 | O. Sewell 6 |
| January 30, 2043 | @ Michigan State Spartans* | L 60-72 | 11-11 | J. Reeder 23 | O. Sewell 6 | D. Finley 11 |
| February 1, 2043 | #6 PURDUE BOILERMAKERS* | W 76-71 | 12-11 | M. Howell 19 | O. Sewell 4 | M. Howell 16 |
| February 6, 2043 | OREGON DUCKS* | L 61-73 | 12-12 | J. Reeder 21 | O. Sewell 8 | D. Finley 6 |
| February 8, 2043 | #5 MINNESOTA GOLDEN GOPHERS* | L 70-76 | 12-13 | J. Bush 22 | O. Sewell 3 | M. Howell 10 |
| February 13, 2043 | UCLA BRUINS (9-15, 4-10, 1-7 Away)* | - | | | | |
| February 15, 2043 | @ Penn State Nittany Lions (18-5, 12-2, 10-1 Home)* | - | | | | |
| February 20, 2043 | @ Wisconsin Badgers (11-12, 6-8, 11-3 Home)* | - | | | | |
| February 22, 2043 | @ Minnesota Golden Gophers (21-4, 12-2, 12-2 Home)* | - | | | | |
| February 27, 2043 | IOWA HAWKEYES (18-7, 8-6, 6-4 Away)* | - | | | | |
| March 1, 2043 | PENN STATE NITTANY LIONS (18-5, 12-2, 8-3 Away)* | - | | | | |
