| November 14, 2042 | @ Arizona Wildcats | L 57-88 | 0-1 | K. Gifford 13 | E. Lee 2 | L. Jonas 7 |
| November 19, 2042 | BELLARMINE KNIGHTS | L 60-73 | 0-2 | E. Lee 17 | E. Lee 4 | M. Shaffer 8 |
| November 21, 2042 | OREGON STATE BEAVERS Hall of Fame Classic | L 60-64 | 0-3 | L. Jonas 11 | E. Lee 4 | M. Shaffer 7 |
| November 26, 2042 | TEXAS STATE BOBCATS | W 79-59 | 1-3 | L. Jonas 16 | E. Lee 5 | L. Jonas 13 |
| November 29, 2042 | FORDHAM RAMS | L 74-76 | 1-4 | A. Taylor 22 | E. Lee 6 | L. Jonas 10 |
| December 7, 2042 | SAINT PETER'S PEACOCKS | W 69-59 | 2-4 | L. Jonas 14 | E. Lee 8 | E. Lee 6 |
| December 13, 2042 | VIRGINIA TECH HOKIES | W 84-73 | 3-4 | E. Lee 20 | E. Lee 7 | L. Jonas 8 |
| December 21, 2042 | SAMFORD BULLDOGS | W 73-50 | 4-4 | E. Lee 23 | E. Lee 4 | M. Shaffer 9 |
| December 23, 2042 | NJIT HIGHLANDERS | L 55-78 | 4-5 | N. Mills 12 | D. Mann 5 | M. Shaffer 12 |
| December 26, 2042 | INDIANA HOOSIERS (7-4, 0-0, 1-3 Away)* | - | | | | |
| December 28, 2042 | @ Purdue Boilermakers (10-1, 0-0, 7-1 Home)* | - | | | | |
| January 2, 2043 | @ Oregon Ducks (4-5, 0-0, 4-2 Home)* | - | | | | |
| January 4, 2043 | NORTHWESTERN WILDCATS (5-6, 0-0, 1-2 Away)* | - | | | | |
| January 9, 2043 | @ UCLA Bruins (5-5, 0-0, 4-3 Home)* | - | | | | |
| January 11, 2043 | NEBRASKA CORNHUSKERS (3-6, 0-0, 0-2 Away)* | - | | | | |
| January 16, 2043 | @ Washington Huskies (3-6, 0-0, 3-2 Home)* | - | | | | |
| January 18, 2043 | RUTGERS SCARLET KNIGHTS (8-1, 0-0, 0-0 Away)* | - | | | | |
| January 23, 2043 | @ Minnesota Golden Gophers (9-2, 0-0, 5-1 Home)* | - | | | | |
| January 25, 2043 | @ Wisconsin Badgers (5-4, 0-0, 5-2 Home)* | - | | | | |
| January 30, 2043 | ILLINOIS FIGHTING ILLINI (7-2, 0-0, 2-2 Away)* | - | | | | |
| February 1, 2043 | @ Maryland Terrapins (7-3, 0-0, 5-0 Home)* | - | | | | |
| February 6, 2043 | PENN STATE NITTANY LIONS (6-3, 0-0, 1-2 Away)* | - | | | | |
| February 8, 2043 | IOWA HAWKEYES (9-1, 0-0, 3-1 Away)* | - | | | | |
| February 13, 2043 | @ USC Trojans (8-2, 0-0, 6-0 Home)* | - | | | | |
| February 15, 2043 | @ Michigan State Spartans (7-3, 0-0, 4-0 Home)* | - | | | | |
| February 20, 2043 | MICHIGAN WOLVERINES (4-5, 0-0, 0-2 Away)* | - | | | | |
| February 22, 2043 | WASHINGTON HUSKIES (3-6, 0-0, 0-3 Away)* | - | | | | |
| February 27, 2043 | PURDUE BOILERMAKERS (10-1, 0-0, 0-0 Away)* | - | | | | |
| March 1, 2043 | @ Rutgers Scarlet Knights (8-1, 0-0, 8-0 Home)* | - | | | | |
