| November 14, 2042 | @ Arizona Wildcats | L 57-88 | 0-1 | K. Gifford 13 | E. Lee 2 | L. Jonas 7 |
| November 19, 2042 | BELLARMINE KNIGHTS | L 60-73 | 0-2 | E. Lee 17 | E. Lee 4 | M. Shaffer 8 |
| November 21, 2042 | OREGON STATE BEAVERS Hall of Fame Classic | L 60-64 | 0-3 | L. Jonas 11 | E. Lee 4 | M. Shaffer 7 |
| November 26, 2042 | TEXAS STATE BOBCATS | W 79-59 | 1-3 | L. Jonas 16 | E. Lee 5 | L. Jonas 13 |
| November 29, 2042 | FORDHAM RAMS | L 74-76 | 1-4 | A. Taylor 22 | E. Lee 6 | L. Jonas 10 |
| December 7, 2042 | SAINT PETER'S PEACOCKS | W 69-59 | 2-4 | L. Jonas 14 | E. Lee 8 | E. Lee 6 |
| December 13, 2042 | VIRGINIA TECH HOKIES | W 84-73 | 3-4 | E. Lee 20 | E. Lee 7 | L. Jonas 8 |
| December 21, 2042 | SAMFORD BULLDOGS | W 73-50 | 4-4 | E. Lee 23 | E. Lee 4 | M. Shaffer 9 |
| December 23, 2042 | NJIT HIGHLANDERS | L 55-78 | 4-5 | N. Mills 12 | D. Mann 5 | M. Shaffer 12 |
| December 26, 2042 | INDIANA HOOSIERS* | L 77-82 | 4-6 | E. Lee 24 | E. Lee 3 | L. Jonas 8 |
| December 28, 2042 | @ #4 Purdue Boilermakers* | L 57-92 | 4-7 | C. Little 16 | E. Lee 5 | C. Little 6 |
| January 2, 2043 | @ Oregon Ducks* | L 64-75 | 4-8 | L. Jonas 16 | E. Lee 5 | L. Jonas 11 |
| January 4, 2043 | NORTHWESTERN WILDCATS* | L 50-63 | 4-9 | M. Shaffer 12 | E. Lee 5 | E. Lee 6 |
| January 9, 2043 | @ UCLA Bruins* | L 69-74 | 4-10 | E. Lee 14 | E. Lee 6 | L. Jonas 8 |
| January 11, 2043 | NEBRASKA CORNHUSKERS* | W 79-62 | 5-10 | E. Lee 21 | A. Monahan 4 | M. Shaffer 15 |
| January 16, 2043 | @ Washington Huskies* | L 54-62 | 5-11 | M. Shaffer 10 | E. Lee 5 | M. Shaffer 7 |
| January 18, 2043 | RUTGERS SCARLET KNIGHTS* | W 76-61 | 6-11 | A. Monahan 14 | E. Lee 5 | M. Shaffer 8 |
| January 23, 2043 | @ #5 Minnesota Golden Gophers* | L 73-96 | 6-12 | M. Shaffer 22 | E. Lee 6 | A. Taylor 5 |
| January 25, 2043 | @ Wisconsin Badgers* | L 63-77 | 6-13 | E. Lee 19 | R. Slater 4 | L. Jonas 6 |
| January 30, 2043 | ILLINOIS FIGHTING ILLINI* | L 59-74 | 6-14 | M. Shaffer 14 | L. Jonas 4 | M. Shaffer 12 |
| February 1, 2043 | @ #11 Maryland Terrapins* | L 52-89 | 6-15 | E. Lee 12 | E. Lee 4 | A. Monahan 5 |
| February 6, 2043 | PENN STATE NITTANY LIONS* | L 64-87 | 6-16 | E. Lee 14 | N. Mills 5 | L. Jonas 9 |
| February 8, 2043 | #17 IOWA HAWKEYES* | L 46-74 | 6-17 | M. Shaffer 10 | E. Lee 2 | L. Jonas 8 |
| February 13, 2043 | @ USC Trojans* | L 65-77 | 6-18 | E. Lee 15 | K. Gifford 3 | K. Gifford 10 |
| February 15, 2043 | @ Michigan State Spartans* | L 42-59 | 6-19 | L. Jonas 13 | E. Lee 3 | L. Jonas 7 |
| February 20, 2043 | MICHIGAN WOLVERINES (13-12, 9-7, 3-6 Away)* | - | | | | |
| February 22, 2043 | WASHINGTON HUSKIES (5-20, 2-14, 0-11 Away)* | - | | | | |
| February 27, 2043 | PURDUE BOILERMAKERS (20-7, 10-6, 3-5 Away)* | - | | | | |
| March 1, 2043 | @ Rutgers Scarlet Knights (12-13, 4-12, 11-4 Home)* | - | | | | |
