| November 15, 2042 | MISSISSIPPI STATE BULLDOGS | L 57-62 | 0-1 | T. Smith 14 | A. Towers 5 | T. Cornett 18 |
| November 19, 2042 | MARSHALL THUNDERING HERD | W 72-49 | 1-1 | T. Smith 15 | A. Towers 6 | T. Cornett 9 |
| November 22, 2042 | FLORIDA GATORS | W 81-72 | 2-1 | D. Saldana 14 | A. Towers 4 | A. Riggs 12 |
| November 25, 2042 | TULSA GOLDEN HURRICANES Myrtle Beach Invitational | L 74-77 | 2-2 | D. Saldana 22 | A. Towers 7 | T. Cornett 14 |
| November 30, 2042 | @ Temple Owls | L 83-89 | 2-3 | T. Smith 22 | T. Smith 6 | T. Cornett 11 |
| December 3, 2042 | GRAND CANYON ANTELOPES | W 70-53 | 3-3 | T. Cornett 17 | A. Towers 6 | R. Lancaster 12 |
| December 7, 2042 | TULSA GOLDEN HURRICANES | W 87-59 | 4-3 | A. Dabbert 19 | A. Towers 4 | T. Cornett 9 |
| December 13, 2042 | @ Oregon State Beavers | L 67-74 | 4-4 | T. Cornett 14 | A. Dabbert 4 | T. Cornett 11 |
| December 16, 2042 | #17 VCU RAMS | L 68-79 | 4-5 | T. Smith 19 | A. Towers 6 | T. Cornett 11 |
| December 26, 2042 | PENN STATE NITTANY LIONS* | W 93-87 | 5-5 | R. Lancaster 24 | A. Towers 6 | T. Cornett 9 |
| December 28, 2042 | RUTGERS SCARLET KNIGHTS* | W 87-84 | 6-5 | T. Smith 21 | A. Towers 7 | T. Cornett 12 |
| January 2, 2043 | OHIO STATE BUCKEYES* | W 75-64 | 7-5 | A. Towers 21 | A. Towers 6 | T. Cornett 7 |
| January 4, 2043 | @ Washington Huskies* | W 83-76 | 8-5 | A. Dabbert 14 | A. Towers 5 | A. Riggs 8 |
| January 9, 2043 | ILLINOIS FIGHTING ILLINI* | W 87-64 | 9-5 | T. Smith 21 | A. Towers 7 | T. Cornett 15 |
| January 11, 2043 | WISCONSIN BADGERS* | W 88-65 | 10-5 | D. Saldana 14 | A. Towers 7 | T. Cornett 13 |
| January 16, 2043 | @ Michigan State Spartans* | L 71-95 | 10-6 | R. Lancaster 23 | A. Towers 7 | R. Lancaster 8 |
| January 18, 2043 | #6 MINNESOTA GOLDEN GOPHERS* | L 75-78 OT | 10-7 | A. Dabbert 21 | A. Towers 5 | T. Cornett 10 |
| January 23, 2043 | @ Michigan Wolverines* | W 81-73 | 11-7 | A. Dabbert 17 | E. Pyle 3 | H. Hoffman 11 |
| January 25, 2043 | NEBRASKA CORNHUSKERS* | W 86-75 | 12-7 | T. Cornett 25 | A. Towers 6 | T. Cornett 15 |
| January 30, 2043 | UCLA BRUINS* | L 75-78 | 12-8 | T. Smith 24 | A. Towers 5 | T. Cornett 14 |
| February 1, 2043 | @ USC Trojans* | L 67-91 | 12-9 | T. Smith 27 | A. Towers 5 | T. Cornett 10 |
| February 6, 2043 | @ Northwestern Wildcats* | W 73-61 | 13-9 | T. Smith 14 | A. Towers 6 | T. Cornett 13 |
| February 8, 2043 | @ Indiana Hoosiers* | L 89-98 OT | 13-10 | T. Smith 23 | R. Lancaster 6 | R. Lancaster 11 |
| February 13, 2043 | @ Purdue Boilermakers (18-7, 8-6, 12-2 Home)* | - | | | | |
| February 15, 2043 | @ Iowa Hawkeyes (18-7, 8-6, 9-3 Home)* | - | | | | |
| February 20, 2043 | MARYLAND TERRAPINS (16-8, 9-5, 6-5 Away)* | - | | | | |
| February 22, 2043 | IOWA HAWKEYES (18-7, 8-6, 6-4 Away)* | - | | | | |
| February 27, 2043 | @ Nebraska Cornhuskers (5-18, 2-12, 5-9 Home)* | - | | | | |
| March 1, 2043 | @ Maryland Terrapins (16-8, 9-5, 9-2 Home)* | - | | | | |
