| November 15, 2042 | MISSISSIPPI STATE BULLDOGS | L 57-62 | 0-1 | T. Smith 14 | A. Towers 5 | T. Cornett 18 |
| November 19, 2042 | MARSHALL THUNDERING HERD | W 72-49 | 1-1 | T. Smith 15 | A. Towers 6 | T. Cornett 9 |
| November 22, 2042 | FLORIDA GATORS | W 81-72 | 2-1 | D. Saldana 14 | A. Towers 4 | A. Riggs 12 |
| November 25, 2042 | TULSA GOLDEN HURRICANES Myrtle Beach Invitational | L 74-77 | 2-2 | D. Saldana 22 | A. Towers 7 | T. Cornett 14 |
| November 30, 2042 | @ Temple Owls | L 83-89 | 2-3 | T. Smith 22 | T. Smith 6 | T. Cornett 11 |
| December 3, 2042 | GRAND CANYON ANTELOPES | W 70-53 | 3-3 | T. Cornett 17 | A. Towers 6 | R. Lancaster 12 |
| December 7, 2042 | TULSA GOLDEN HURRICANES | W 87-59 | 4-3 | A. Dabbert 19 | A. Towers 4 | T. Cornett 9 |
| December 13, 2042 | @ Oregon State Beavers | L 67-74 | 4-4 | T. Cornett 14 | A. Dabbert 4 | T. Cornett 11 |
| December 16, 2042 | #17 VCU RAMS | L 68-79 | 4-5 | T. Smith 19 | A. Towers 6 | T. Cornett 11 |
| December 26, 2042 | PENN STATE NITTANY LIONS (6-3, 0-0, 1-2 Away)* | - | | | | |
| December 28, 2042 | RUTGERS SCARLET KNIGHTS (8-1, 0-0, 0-0 Away)* | - | | | | |
| January 2, 2043 | OHIO STATE BUCKEYES (4-5, 0-0, 0-1 Away)* | - | | | | |
| January 4, 2043 | @ Washington Huskies (3-6, 0-0, 3-2 Home)* | - | | | | |
| January 9, 2043 | ILLINOIS FIGHTING ILLINI (7-2, 0-0, 2-2 Away)* | - | | | | |
| January 11, 2043 | WISCONSIN BADGERS (5-4, 0-0, 0-1 Away)* | - | | | | |
| January 16, 2043 | @ Michigan State Spartans (7-3, 0-0, 4-0 Home)* | - | | | | |
| January 18, 2043 | MINNESOTA GOLDEN GOPHERS (9-2, 0-0, 2-0 Away)* | - | | | | |
| January 23, 2043 | @ Michigan Wolverines (4-5, 0-0, 4-2 Home)* | - | | | | |
| January 25, 2043 | NEBRASKA CORNHUSKERS (3-6, 0-0, 0-2 Away)* | - | | | | |
| January 30, 2043 | UCLA BRUINS (5-5, 0-0, 0-1 Away)* | - | | | | |
| February 1, 2043 | @ USC Trojans (8-2, 0-0, 6-0 Home)* | - | | | | |
| February 6, 2043 | @ Northwestern Wildcats (5-6, 0-0, 2-3 Home)* | - | | | | |
| February 8, 2043 | @ Indiana Hoosiers (7-4, 0-0, 3-1 Home)* | - | | | | |
| February 13, 2043 | @ Purdue Boilermakers (10-1, 0-0, 7-1 Home)* | - | | | | |
| February 15, 2043 | @ Iowa Hawkeyes (9-1, 0-0, 4-0 Home)* | - | | | | |
| February 20, 2043 | MARYLAND TERRAPINS (7-3, 0-0, 1-2 Away)* | - | | | | |
| February 22, 2043 | IOWA HAWKEYES (9-1, 0-0, 3-1 Away)* | - | | | | |
| February 27, 2043 | @ Nebraska Cornhuskers (3-6, 0-0, 3-3 Home)* | - | | | | |
| March 1, 2043 | @ Maryland Terrapins (7-3, 0-0, 5-0 Home)* | - | | | | |
