| November 16, 2042 | UT MARTIN SKYHAWKS | W 99-69 | 1-0 | J. Ledesma 19 | R. Darnell 6 | R. Bledsoe 9 |
| November 18, 2042 | SEATTLE REDHAWKS Allstate Maui Invitational | L 78-83 | 1-1 | R. Darnell 19 | R. Darnell 6 | D. Perez 6 |
| November 22, 2042 | DAYTON FLYERS | W 99-83 | 2-1 | R. Darnell 21 | R. Darnell 6 | D. Perez 11 |
| November 26, 2042 | @ #15 Louisville Cardinals | L 78-94 | 2-2 | R. Darnell 19 | R. Darnell 5 | D. Perez 10 |
| November 30, 2042 | @ George Washington Colonials | W 111-87 | 3-2 | R. Darnell 19 | E. Mistry 6 | D. Perez 12 |
| December 3, 2042 | @ #16 Florida State Seminoles | L 64-72 | 3-3 | R. Darnell 13 | R. Darnell 2 | D. Perez 12 |
| December 7, 2042 | CENTRAL MICHIGAN CHIPPEWAS | W 87-72 | 4-3 | J. Ledesma 25 | R. Darnell 5 | R. Bledsoe 11 |
| December 10, 2042 | MEMPHIS TIGERS | W 83-64 | 5-3 | J. Ledesma 18 | E. Mistry 5 | D. Perez 10 |
| December 13, 2042 | PITTSBURGH PANTHERS | W 88-75 | 6-3 | R. Darnell 23 | R. Darnell 3 | R. Bledsoe 10 |
| December 26, 2042 | @ Oregon Ducks* | L 87-93 | 6-4 | R. Darnell 19 | T. Braden 4 | R. Bledsoe 11 |
| December 28, 2042 | @ Indiana Hoosiers* | W 82-77 | 7-4 | R. Bledsoe 17 | R. Darnell 6 | C. Putnam 10 |
| January 2, 2043 | #2 PURDUE BOILERMAKERS* | W 93-84 | 8-4 | T. Braden 23 | R. Darnell 9 | T. Braden 8 |
| January 4, 2043 | @ Nebraska Cornhuskers* | W 92-83 | 9-4 | R. Darnell 27 | R. Darnell 4 | C. Putnam 10 |
| January 9, 2043 | MICHIGAN WOLVERINES* | W 88-56 | 10-4 | E. Mistry 18 | R. Darnell 7 | R. Bledsoe 9 |
| January 11, 2043 | MICHIGAN STATE SPARTANS* | W 77-68 | 11-4 | D. Grady 16 | E. Mistry 4 | D. Perez 7 |
| January 16, 2043 | #16 IOWA HAWKEYES* | W 78-70 | 12-4 | C. Putnam 18 | R. Darnell 7 | C. Putnam 11 |
| January 18, 2043 | ILLINOIS FIGHTING ILLINI* | L 80-87 | 12-5 | T. Braden 16 | T. Braden 5 | D. Perez 10 |
| January 23, 2043 | @ #11 Maryland Terrapins* | W 86-68 | 13-5 | R. Bledsoe 29 | R. Darnell 6 | R. Bledsoe 10 |
| January 25, 2043 | @ USC Trojans* | W 83-75 | 14-5 | R. Bledsoe 29 | R. Darnell 8 | R. Bledsoe 9 |
| January 30, 2043 | WASHINGTON HUSKIES* | W 107-86 | 15-5 | R. Darnell 25 | E. Mistry 6 | D. Perez 13 |
| February 1, 2043 | @ Rutgers Scarlet Knights* | W 81-66 | 16-5 | R. Darnell 18 | R. Darnell 3 | R. Bledsoe 8 |
| February 6, 2043 | @ Ohio State Buckeyes* | W 87-64 | 17-5 | R. Bledsoe 21 | R. Darnell 9 | D. Perez 7 |
| February 8, 2043 | @ UCLA Bruins* | W 83-71 | 18-5 | D. Perez 16 | R. Darnell 5 | D. Perez 11 |
| February 13, 2043 | @ Wisconsin Badgers (11-12, 6-8, 11-3 Home)* | - | | | | |
| February 15, 2043 | NORTHWESTERN WILDCATS (12-13, 7-7, 4-6 Away)* | - | | | | |
| February 20, 2043 | MINNESOTA GOLDEN GOPHERS (21-4, 12-2, 7-1 Away)* | - | | | | |
| February 22, 2043 | NEBRASKA CORNHUSKERS (5-18, 2-12, 0-8 Away)* | - | | | | |
| February 27, 2043 | WISCONSIN BADGERS (11-12, 6-8, 0-8 Away)* | - | | | | |
| March 1, 2043 | @ Northwestern Wildcats (12-13, 7-7, 6-6 Home)* | - | | | | |
