| November 16, 2042 | @ George Washington Colonials | L 74-79 | 0-1 | W. Cunningham 12 | W. Cunningham 5 | S. Grant 10 |
| November 19, 2042 | GEORGIA STATE PANTHERS | W 70-53 | 1-1 | W. Cunningham 21 | W. Cunningham 3 | L. Townsend 12 |
| November 21, 2042 | SIU EDWARDSVILLE COUGARS Charleston Classic | W 79-74 | 2-1 | W. Cunningham 15 | C. Ellington 3 | L. Townsend 21 |
| November 22, 2042 | @ Detroit Mercy Titans Charleston Classic | W 78-71 | 3-1 | S. Grant 23 | A. Haskins 4 | L. Townsend 17 |
| November 23, 2042 | @ Ole Miss Rebels Charleston Classic | W 100-93 | 4-1 | A. Haskins 22 | W. Cunningham 7 | L. Townsend 14 |
| November 26, 2042 | @ St. John's Red Storm | L 63-66 | 4-2 | L. Townsend 18 | W. Cunningham 4 | L. Townsend 12 |
| November 30, 2042 | STONEHILL SKYHAWKS | L 87-94 | 4-3 | C. Ellington 14 | W. Cunningham 6 | S. Grant 10 |
| December 3, 2042 | LIBERTY FLAMES | W 77-66 | 5-3 | W. Cunningham 21 | W. Cunningham 7 | W. Cunningham 7 |
| December 7, 2042 | YOUNGSTOWN STATE PENGUINS | W 71-58 | 6-3 | W. Cunningham 22 | W. Cunningham 5 | L. Townsend 13 |
| December 13, 2042 | @ Penn State Nittany Lions | L 75-88 | 6-4 | W. Cunningham 15 | W. Cunningham 5 | L. Townsend 11 |
| December 21, 2042 | HAWAI'I RAINBOW WARRIORS | W 88-69 | 7-4 | S. Grant 19 | E. Kern 5 | L. Townsend 13 |
| December 26, 2042 | SMU MUSTANGS* | W 69-58 | 8-4 | L. Townsend 13 | W. Cunningham 6 | L. Townsend 10 |
| December 28, 2042 | SYRACUSE ORANGE* | L 62-66 | 8-5 | C. Ellington 16 | A. Haskins 3 | L. Townsend 9 |
| January 2, 2043 | #3 NORTH CAROLINA TAR HEELS* | L 73-83 | 8-6 | W. Cunningham 14 | W. Cunningham 4 | L. Townsend 9 |
| January 4, 2043 | @ Duke Blue Devils* | W 74-70 | 9-6 | C. Ellington 23 | W. Cunningham 6 | L. Townsend 14 |
| January 9, 2043 | #21 MIAMI (FL) HURRICANES* | W 67-66 | 10-6 | L. Townsend 16 | E. Kern 5 | L. Townsend 14 |
| January 11, 2043 | BOSTON COLLEGE EAGLES* | W 82-77 | 11-6 | W. Cunningham 24 | W. Cunningham 5 | L. Townsend 10 |
| January 16, 2043 | @ Georgia Tech Yellow Jackets* | W 71-66 | 12-6 | W. Cunningham 22 | C. Ellington 4 | L. Townsend 13 |
| January 18, 2043 | #19 LOUISVILLE CARDINALS* | W 74-65 | 13-6 | S. Grant 26 | A. Haskins 6 | S. Grant 12 |
| January 23, 2043 | @ California Golden Bears* | L 73-83 | 13-7 | L. Townsend 13 | W. Cunningham 8 | S. Grant 11 |
| January 25, 2043 | NC STATE WOLFPACK* | L 73-79 | 13-8 | S. Grant 14 | W. Cunningham 9 | S. Grant 9 |
| January 30, 2043 | #8 STANFORD CARDINAL* | W 88-80 | 14-8 | W. Cunningham 25 | W. Cunningham 5 | C. Ellington 7 |
| February 1, 2043 | @ #12 Notre Dame Fighting Irish* | L 74-87 | 14-9 | W. Cunningham 22 | W. Cunningham 6 | L. Townsend 5 |
| February 6, 2043 | @ Virginia Cavaliers* | L 64-74 | 14-10 | S. Grant 14 | A. Haskins 5 | L. Townsend 7 |
| February 8, 2043 | @ Clemson Tigers* | W 92-78 | 15-10 | S. Grant 32 | E. Kern 6 | L. Townsend 11 |
| February 13, 2043 | @ Florida State Seminoles (14-9, 7-7, 11-2 Home)* | - | | | | |
| February 15, 2043 | @ Wake Forest Demon Deacons (6-18, 3-11, 3-8 Home)* | - | | | | |
| February 20, 2043 | VIRGINIA TECH HOKIES (4-20, 0-14, 0-10 Away)* | - | | | | |
| February 22, 2043 | WAKE FOREST DEMON DEACONS (6-18, 3-11, 2-9 Away)* | - | | | | |
| February 27, 2043 | @ NC State Wolfpack (15-8, 9-5, 12-2 Home)* | - | | | | |
| March 1, 2043 | @ Virginia Tech Hokies (4-20, 0-14, 3-9 Home)* | - | | | | |
