| November 16, 2042 | @ George Washington Colonials | L 74-79 | 0-1 | W. Cunningham 12 | W. Cunningham 5 | S. Grant 10 |
| November 19, 2042 | GEORGIA STATE PANTHERS | W 70-53 | 1-1 | W. Cunningham 21 | W. Cunningham 3 | L. Townsend 12 |
| November 21, 2042 | SIU EDWARDSVILLE COUGARS Charleston Classic | W 79-74 | 2-1 | W. Cunningham 15 | C. Ellington 3 | L. Townsend 21 |
| November 22, 2042 | @ Detroit Mercy Titans Charleston Classic | W 78-71 | 3-1 | S. Grant 23 | A. Haskins 4 | L. Townsend 17 |
| November 23, 2042 | @ Ole Miss Rebels Charleston Classic | W 100-93 | 4-1 | A. Haskins 22 | W. Cunningham 7 | L. Townsend 14 |
| November 26, 2042 | @ St. John's Red Storm | L 63-66 | 4-2 | L. Townsend 18 | W. Cunningham 4 | L. Townsend 12 |
| November 30, 2042 | STONEHILL SKYHAWKS | L 87-94 | 4-3 | C. Ellington 14 | W. Cunningham 6 | S. Grant 10 |
| December 3, 2042 | LIBERTY FLAMES | W 77-66 | 5-3 | W. Cunningham 21 | W. Cunningham 7 | W. Cunningham 7 |
| December 7, 2042 | YOUNGSTOWN STATE PENGUINS | W 71-58 | 6-3 | W. Cunningham 22 | W. Cunningham 5 | L. Townsend 13 |
| December 13, 2042 | @ Penn State Nittany Lions | L 75-88 | 6-4 | W. Cunningham 15 | W. Cunningham 5 | L. Townsend 11 |
| December 21, 2042 | HAWAI'I RAINBOW WARRIORS | W 88-69 | 7-4 | S. Grant 19 | E. Kern 5 | L. Townsend 13 |
| December 26, 2042 | SMU MUSTANGS (6-4, 0-0, 0-1 Away)* | - | | | | |
| December 28, 2042 | SYRACUSE ORANGE (6-3, 0-0, 1-1 Away)* | - | | | | |
| January 2, 2043 | NORTH CAROLINA TAR HEELS (10-1, 0-0, 2-1 Away)* | - | | | | |
| January 4, 2043 | @ Duke Blue Devils (5-4, 0-0, 4-1 Home)* | - | | | | |
| January 9, 2043 | MIAMI (FL) HURRICANES (9-2, 0-0, 2-1 Away)* | - | | | | |
| January 11, 2043 | BOSTON COLLEGE EAGLES (3-6, 0-0, 1-2 Away)* | - | | | | |
| January 16, 2043 | @ Georgia Tech Yellow Jackets (8-3, 0-0, 3-1 Home)* | - | | | | |
| January 18, 2043 | LOUISVILLE CARDINALS (9-2, 0-0, 3-0 Away)* | - | | | | |
| January 23, 2043 | @ California Golden Bears (1-8, 0-0, 1-4 Home)* | - | | | | |
| January 25, 2043 | NC STATE WOLFPACK (6-3, 0-0, 0-2 Away)* | - | | | | |
| January 30, 2043 | STANFORD CARDINAL (11-1, 0-0, 1-1 Away)* | - | | | | |
| February 1, 2043 | @ Notre Dame Fighting Irish (8-4, 0-0, 4-1 Home)* | - | | | | |
| February 6, 2043 | @ Virginia Cavaliers (2-7, 0-0, 1-2 Home)* | - | | | | |
| February 8, 2043 | @ Clemson Tigers (2-7, 0-0, 1-3 Home)* | - | | | | |
| February 13, 2043 | @ Florida State Seminoles (7-2, 0-0, 7-0 Home)* | - | | | | |
| February 15, 2043 | @ Wake Forest Demon Deacons (3-7, 0-0, 0-3 Home)* | - | | | | |
| February 20, 2043 | VIRGINIA TECH HOKIES (4-6, 0-0, 0-2 Away)* | - | | | | |
| February 22, 2043 | WAKE FOREST DEMON DEACONS (3-7, 0-0, 2-3 Away)* | - | | | | |
| February 27, 2043 | @ NC State Wolfpack (6-3, 0-0, 6-0 Home)* | - | | | | |
| March 1, 2043 | @ Virginia Tech Hokies (4-6, 0-0, 3-3 Home)* | - | | | | |
