| November 16, 2042 | @ Illinois Fighting Illini | L 66-83 | 0-1 | D. Ho 15 | C. Stoll 5 | T. Kincaid 11 |
| November 19, 2042 | INDIANA HOOSIERS | L 68-74 | 0-2 | T. Kincaid 17 | C. Stoll 5 | T. Kincaid 8 |
| November 23, 2042 | PENNSYLVANIA QUAKERS | W 71-70 | 1-2 | T. Neely 19 | C. Stoll 8 | T. Kincaid 6 |
| November 25, 2042 | @ Gonzaga Bulldogs Myrtle Beach Invitational | L 85-92 | 1-3 | D. Ho 18 | C. Stoll 7 | K. Burks 8 |
| November 29, 2042 | MAINE BLACK BEARS | W 64-59 | 2-3 | T. Kincaid 14 | T. Neely 5 | D. Howell 11 |
| December 2, 2042 | @ Saint Louis Billikens | L 76-90 | 2-4 | C. Stoll 18 | C. Stoll 7 | T. Kincaid 6 |
| December 10, 2042 | SOUTH DAKOTA STATE JACKRABBITS | W 79-61 | 3-4 | T. Neely 20 | C. Stoll 6 | T. Kincaid 11 |
| December 13, 2042 | RHODE ISLAND RAMS | L 71-86 | 3-5 | T. Kincaid 16 | C. Stoll 7 | K. Burks 7 |
| December 16, 2042 | @ Florida Gators | W 86-84 | 4-5 | T. Kincaid 15 | C. Stoll 4 | K. Burks 13 |
| December 26, 2042 | @ #17 Creighton Blue Jays* | W 86-77 | 5-5 | T. Kincaid 15 | T. Neely 4 | T. Kincaid 11 |
| December 28, 2042 | MARQUETTE GOLDEN EAGLES* | L 70-78 | 5-6 | T. Neely 16 | C. Stoll 7 | T. Kincaid 8 |
| December 30, 2042 | SETON HALL PIRATES* | L 83-84 | 5-7 | D. Ho 19 | C. Stoll 6 | D. Howell 13 |
| January 4, 2043 | @ St. John's Red Storm* | L 73-76 | 5-8 | C. Stoll 20 | T. Neely 4 | D. Howell 8 |
| January 11, 2043 | CONNECTICUT HUSKIES* | L 89-94 OT | 5-9 | C. Stoll 26 | C. Stoll 6 | D. Howell 8 |
| January 13, 2043 | VILLANOVA WILDCATS* | W 102-94 | 6-9 | T. Kincaid 22 | C. Stoll 4 | T. Neely 5 |
| January 20, 2043 | @ Xavier Musketeers* | W 97-84 | 7-9 | T. Neely 17 | C. Stoll 6 | D. Ho 6 |
| January 23, 2043 | @ DePaul Blue Demons* | L 73-76 | 7-10 | L. Rudolph 16 | T. Neely 5 | D. Ho 6 |
| January 25, 2043 | GEORGETOWN HOYAS* | W 82-79 | 8-10 | D. Ho 21 | C. Stoll 5 | T. Kincaid 8 |
| January 27, 2043 | ST. JOHN'S RED STORM* | W 90-75 | 9-10 | T. Kincaid 16 | L. Rudolph 6 | D. Howell 7 |
| February 1, 2043 | #10 BUTLER BULLDOGS* | L 69-83 | 9-11 | T. Neely 18 | C. Stoll 9 | D. Ho 9 |
| February 3, 2043 | #20 CREIGHTON BLUE JAYS* | L 83-90 | 9-12 | T. Neely 17 | C. Stoll 13 | C. Stoll 10 |
| February 8, 2043 | @ Villanova Wildcats* | L 67-91 | 9-13 | T. Kincaid 16 | C. Stoll 3 | D. Howell 6 |
| February 10, 2043 | @ Connecticut Huskies* | L 59-70 | 9-14 | T. Neely 18 | T. Neely 3 | K. Burks 7 |
| February 15, 2043 | @ Butler Bulldogs (20-4, 14-0, 11-1 Home)* | - | | | | |
| February 17, 2043 | @ Georgetown Hoyas (8-17, 6-9, 4-5 Home)* | - | | | | |
| February 22, 2043 | XAVIER MUSKETEERS (13-11, 5-9, 3-7 Away)* | - | | | | |
| February 24, 2043 | DEPAUL BLUE DEMONS (10-13, 7-6, 3-5 Away)* | - | | | | |
| March 1, 2043 | @ Seton Hall Pirates (17-6, 9-5, 15-1 Home)* | - | | | | |
| March 3, 2043 | @ Marquette Golden Eagles (14-10, 9-6, 9-4 Home)* | - | | | | |
