| November 16, 2042 | @ Illinois Fighting Illini | L 66-83 | 0-1 | D. Ho 15 | C. Stoll 5 | T. Kincaid 11 |
| November 19, 2042 | INDIANA HOOSIERS | L 68-74 | 0-2 | T. Kincaid 17 | C. Stoll 5 | T. Kincaid 8 |
| November 23, 2042 | PENNSYLVANIA QUAKERS | W 71-70 | 1-2 | T. Neely 19 | C. Stoll 8 | T. Kincaid 6 |
| November 25, 2042 | @ Gonzaga Bulldogs Myrtle Beach Invitational | L 85-92 | 1-3 | D. Ho 18 | C. Stoll 7 | K. Burks 8 |
| November 29, 2042 | MAINE BLACK BEARS | W 64-59 | 2-3 | T. Kincaid 14 | T. Neely 5 | D. Howell 11 |
| December 2, 2042 | @ Saint Louis Billikens | L 76-90 | 2-4 | C. Stoll 18 | C. Stoll 7 | T. Kincaid 6 |
| December 10, 2042 | SOUTH DAKOTA STATE JACKRABBITS | W 79-61 | 3-4 | T. Neely 20 | C. Stoll 6 | T. Kincaid 11 |
| December 13, 2042 | RHODE ISLAND RAMS | L 71-86 | 3-5 | T. Kincaid 16 | C. Stoll 7 | K. Burks 7 |
| December 16, 2042 | @ Florida Gators | W 86-84 | 4-5 | T. Kincaid 15 | C. Stoll 4 | K. Burks 13 |
| December 26, 2042 | @ Creighton Blue Jays (9-2, 0-0, 3-1 Home)* | - | | | | |
| December 28, 2042 | MARQUETTE GOLDEN EAGLES (5-4, 0-0, 1-1 Away)* | - | | | | |
| December 30, 2042 | SETON HALL PIRATES (8-1, 0-0, 0-1 Away)* | - | | | | |
| January 4, 2043 | @ St. John's Red Storm (6-5, 0-0, 4-1 Home)* | - | | | | |
| January 11, 2043 | CONNECTICUT HUSKIES (7-4, 0-0, 1-2 Away)* | - | | | | |
| January 13, 2043 | VILLANOVA WILDCATS (5-4, 0-0, 1-1 Away)* | - | | | | |
| January 20, 2043 | @ Xavier Musketeers (8-2, 0-0, 6-0 Home)* | - | | | | |
| January 23, 2043 | @ DePaul Blue Demons (3-7, 0-0, 2-5 Home)* | - | | | | |
| January 25, 2043 | GEORGETOWN HOYAS (2-8, 0-0, 0-6 Away)* | - | | | | |
| January 27, 2043 | ST. JOHN'S RED STORM (6-5, 0-0, 0-3 Away)* | - | | | | |
| February 1, 2043 | BUTLER BULLDOGS (6-4, 0-0, 1-2 Away)* | - | | | | |
| February 3, 2043 | CREIGHTON BLUE JAYS (9-2, 0-0, 3-1 Away)* | - | | | | |
| February 8, 2043 | @ Villanova Wildcats (5-4, 0-0, 4-2 Home)* | - | | | | |
| February 10, 2043 | @ Connecticut Huskies (7-4, 0-0, 4-1 Home)* | - | | | | |
| February 15, 2043 | @ Butler Bulldogs (6-4, 0-0, 4-1 Home)* | - | | | | |
| February 17, 2043 | @ Georgetown Hoyas (2-8, 0-0, 1-1 Home)* | - | | | | |
| February 22, 2043 | XAVIER MUSKETEERS (8-2, 0-0, 1-1 Away)* | - | | | | |
| February 24, 2043 | DEPAUL BLUE DEMONS (3-7, 0-0, 0-1 Away)* | - | | | | |
| March 1, 2043 | @ Seton Hall Pirates (8-1, 0-0, 8-0 Home)* | - | | | | |
| March 3, 2043 | @ Marquette Golden Eagles (5-4, 0-0, 4-2 Home)* | - | | | | |
