| November 16, 2042 | MISSOURI TIGERS | W 71-66 | 1-0 | P. Quintanilla 19 | D. Garrett 5 | P. Quintanilla 14 |
| November 19, 2042 | WOFFORD TERRIERS | W 86-75 | 2-0 | P. Quintanilla 26 | D. Garrett 7 | P. Quintanilla 12 |
| November 22, 2042 | SAINT LOUIS BILLIKENS | L 72-77 | 2-1 | D. Garrett 20 | D. Garrett 5 | I. Markoulides 12 |
| November 26, 2042 | TROY TROJANS | W 91-77 | 3-1 | P. Quintanilla 27 | W. Crowley 8 | P. Quintanilla 11 |
| November 30, 2042 | STEPHEN F. AUSTIN LUMBERJACKS | W 94-63 | 4-1 | W. Crowley 28 | D. Garrett 14 | I. Markoulides 11 |
| December 7, 2042 | SMU MUSTANGS | W 79-71 | 5-1 | D. Garrett 19 | D. Garrett 5 | P. Quintanilla 11 |
| December 13, 2042 | BUTLER BULLDOGS | W 71-63 | 6-1 | P. Quintanilla 18 | P. Quintanilla 3 | E. Quinteros 12 |
| December 16, 2042 | TROY TROJANS Vegas Showdown | W 97-84 | 7-1 | P. Quintanilla 35 | D. Garrett 10 | P. Quintanilla 15 |
| December 17, 2042 | SOUTH FLORIDA BULLS Vegas Showdown | W 85-75 | 8-1 | P. Quintanilla 25 | D. Garrett 8 | P. Quintanilla 11 |
| December 18, 2042 | @ #18 Oklahoma State Cowboys Vegas Showdown | W 92-86 | 9-1 | P. Quintanilla 25 | D. Garrett 7 | P. Quintanilla 8 |
| December 21, 2042 | NEW MEXICO LOBOS | W 78-64 | 10-1 | P. Quintanilla 21 | D. Garrett 8 | E. Quinteros 13 |
| December 26, 2042 | RUTGERS SCARLET KNIGHTS* | W 91-65 | 11-1 | P. Quintanilla 20 | D. Garrett 6 | E. Quinteros 13 |
| December 28, 2042 | OHIO STATE BUCKEYES* | W 92-57 | 12-1 | P. Quintanilla 21 | D. Garrett 8 | E. Quinteros 12 |
| January 2, 2043 | @ Penn State Nittany Lions* | L 84-93 | 12-2 | P. Quintanilla 28 | D. Garrett 6 | I. Markoulides 12 |
| January 4, 2043 | @ #19 Iowa Hawkeyes* | L 57-73 | 12-3 | P. Quintanilla 19 | D. Garrett 5 | P. Quintanilla 13 |
| January 9, 2043 | USC TROJANS* | W 92-70 | 13-3 | I. Markoulides 26 | D. Garrett 13 | P. Quintanilla 15 |
| January 11, 2043 | @ Washington Huskies* | W 71-57 | 14-3 | E. Quinteros 20 | D. Garrett 7 | I. Markoulides 15 |
| January 16, 2043 | @ Indiana Hoosiers* | L 65-70 | 14-4 | P. Quintanilla 25 | D. Garrett 6 | P. Quintanilla 14 |
| January 18, 2043 | MICHIGAN WOLVERINES* | L 64-69 | 14-5 | P. Quintanilla 20 | D. Garrett 7 | E. Quinteros 10 |
| January 23, 2043 | @ Michigan State Spartans* | L 80-91 | 14-6 | P. Quintanilla 26 | D. Garrett 7 | P. Quintanilla 13 |
| January 25, 2043 | #5 MINNESOTA GOLDEN GOPHERS* | W 85-69 | 15-6 | P. Quintanilla 28 | D. Garrett 5 | I. Markoulides 13 |
| January 30, 2043 | #11 MARYLAND TERRAPINS* | W 89-74 | 16-6 | P. Quintanilla 29 | D. Garrett 5 | E. Quinteros 8 |
| February 1, 2043 | @ Northwestern Wildcats* | L 71-76 | 16-7 | W. Crowley 17 | D. Garrett 4 | E. Quinteros 11 |
| February 6, 2043 | @ UCLA Bruins* | W 91-68 | 17-7 | P. Quintanilla 20 | D. Garrett 7 | P. Quintanilla 13 |
| February 8, 2043 | @ Nebraska Cornhuskers* | W 92-80 | 18-7 | P. Quintanilla 32 | D. Garrett 13 | P. Quintanilla 13 |
| February 13, 2043 | OREGON DUCKS* | W 76-65 | 19-7 | P. Quintanilla 17 | W. Crowley 4 | I. Markoulides 15 |
| February 15, 2043 | WISCONSIN BADGERS* | W 90-70 | 20-7 | P. Quintanilla 30 | W. Fuhs 5 | P. Quintanilla 8 |
| February 20, 2043 | ILLINOIS FIGHTING ILLINI* | W 89-71 | 21-7 | P. Quintanilla 35 | D. Garrett 8 | P. Quintanilla 11 |
| February 22, 2043 | @ Rutgers Scarlet Knights* | W 93-65 | 22-7 | P. Quintanilla 24 | W. Fuhs 8 | P. Quintanilla 11 |
| February 27, 2043 | @ Ohio State Buckeyes* | W 80-63 | 23-7 | W. Crowley 17 | D. Garrett 7 | E. Quinteros 12 |
| March 1, 2043 | #18 IOWA HAWKEYES* | L 72-73 | 23-8 | P. Quintanilla 24 | D. Garrett 10 | D. Coon 9 |
| March 10, 2043 | ILLINOIS FIGHTING ILLINI Big 10 Tournament | W 84-69 | 24-8 | P. Quintanilla 27 | W. Crowley 5 | P. Quintanilla 10 |
| March 11, 2043 | @ Indiana Hoosiers Big 10 Tournament | L 79-82 | 24-9 | P. Quintanilla 25 | D. Garrett 8 | P. Quintanilla 12 |
| March 16, 2043 | SIU EDWARDSVILLE COUGARS NCAA Tournament | W 68-53 | 25-9 | P. Quintanilla 18 | D. Garrett 9 | P. Quintanilla 12 |
| March 18, 2043 | #22 TENNESSEE VOLUNTEERS NCAA Tournament | W 89-74 | 26-9 | P. Quintanilla 30 | D. Garrett 8 | E. Quinteros 9 |
| March 23, 2043 | @ Youngstown State Penguins NCAA Tournament | W 88-73 | 27-9 | D. Garrett 19 | D. Garrett 6 | P. Quintanilla 12 |
| March 25, 2043 | @ #1 North Carolina Tar Heels NCAA Tournament | W 77-73 | 28-9 | W. Crowley 15 | D. Garrett 8 | P. Quintanilla 14 |
| April 1, 2043 | #25 MARYLAND TERRAPINS NCAA Tournament | W 101-82 | 29-9 | W. Crowley 28 | D. Garrett 5 | E. Quinteros 7 |
| April 3, 2043 | #9 VCU RAMS NCAA Tournament | L 66-75 | 29-10 | P. Quintanilla 22 | W. Crowley 4 | P. Quintanilla 9 |
