| November 15, 2042 | NEW HAMPSHIRE WILDCATS | W 99-79 | 1-0 | C. Hordemann 25 | J. Lytle 4 | R. Rowland 6 |
| November 19, 2042 | WESTERN KENTUCKY HILLTOPPERS | W 72-69 | 2-0 | J. Lytle 14 | J. Howell 6 | J. Howell 8 |
| November 22, 2042 | GEORGE MASON PATRIOTS | W 74-65 | 3-0 | C. Hordemann 20 | C. Hordemann 4 | J. Akins 9 |
| November 26, 2042 | CHICAGO STATE COUGARS | W 90-74 | 4-0 | C. Hordemann 20 | J. Lytle 3 | J. Howell 8 |
| November 30, 2042 | CENTRAL ARKANSAS BEARS | W 77-52 | 5-0 | C. Hordemann 16 | T. Noble 3 | J. Howell 7 |
| December 7, 2042 | LOUISIANA RAGIN' CAJUNS | W 96-61 | 6-0 | T. Forrest 23 | J. Lytle 5 | R. Rowland 9 |
| December 13, 2042 | #21 SETON HALL PIRATES | W 85-77 | 7-0 | C. Hordemann 35 | C. Hordemann 3 | J. Lytle 7 |
| December 16, 2042 | SAINT JOSEPH'S HAWKS Bad Boy Mowers Battle 4 Atlantis | L 86-90 | 7-1 | C. Hordemann 27 | C. Hordemann 4 | J. Howell 7 |
| December 21, 2042 | ABILENE CHRISTIAN WILDCATS | W 81-65 | 8-1 | J. Howell 20 | C. Hordemann 5 | J. Howell 10 |
| December 26, 2042 | @ #4 Purdue Boilermakers* | L 65-91 | 8-2 | C. Hordemann 24 | J. Lytle 3 | J. Howell 5 |
| December 28, 2042 | @ Oregon Ducks* | L 84-87 | 8-3 | C. Hordemann 22 | C. Hordemann 4 | J. Howell 13 |
| January 2, 2043 | INDIANA HOOSIERS* | L 73-86 | 8-4 | J. Lytle 19 | T. Noble 3 | K. Dickens 7 |
| January 4, 2043 | @ Michigan State Spartans* | L 55-84 | 8-5 | C. Hordemann 12 | J. Lytle 1 | J. Howell 14 |
| January 9, 2043 | @ #7 Minnesota Golden Gophers* | L 51-80 | 8-6 | J. Howell 15 | C. Hordemann 5 | J. Howell 6 |
| January 11, 2043 | NORTHWESTERN WILDCATS* | W 81-70 | 9-6 | C. Hordemann 18 | C. Hordemann 5 | J. Lytle 8 |
| January 16, 2043 | @ USC Trojans* | L 92-114 | 9-7 | T. Noble 17 | C. Hordemann 5 | J. Lytle 6 |
| January 18, 2043 | @ Ohio State Buckeyes* | L 61-76 | 9-8 | C. Hordemann 18 | C. Hordemann 5 | R. Rowland 8 |
| January 23, 2043 | @ Wisconsin Badgers* | L 55-57 | 9-9 | C. Hordemann 14 | C. Hordemann 4 | J. Howell 13 |
| January 25, 2043 | @ Illinois Fighting Illini* | L 82-89 | 9-10 | C. Hordemann 26 | J. Lytle 7 | J. Akins 5 |
| January 30, 2043 | #17 IOWA HAWKEYES* | L 61-62 | 9-11 | T. Forrest 12 | C. Hordemann 4 | J. Howell 11 |
| February 1, 2043 | PENN STATE NITTANY LIONS* | L 66-81 | 9-12 | C. Hordemann 15 | J. Lytle 2 | R. Rowland 7 |
| February 6, 2043 | WASHINGTON HUSKIES* | W 86-64 | 10-12 | C. Hordemann 18 | J. Lytle 3 | J. Howell 8 |
| February 8, 2043 | @ #14 Maryland Terrapins* | W 80-76 | 11-12 | C. Hordemann 20 | C. Hordemann 3 | C. Hordemann 6 |
| February 13, 2043 | MICHIGAN WOLVERINES (12-11, 8-6, 2-6 Away)* | - | | | | |
| February 15, 2043 | NEBRASKA CORNHUSKERS (5-18, 2-12, 0-8 Away)* | - | | | | |
| February 20, 2043 | @ UCLA Bruins (9-15, 4-10, 7-7 Home)* | - | | | | |
| February 22, 2043 | PURDUE BOILERMAKERS (18-7, 8-6, 3-5 Away)* | - | | | | |
| February 27, 2043 | ILLINOIS FIGHTING ILLINI (16-7, 9-5, 4-6 Away)* | - | | | | |
| March 1, 2043 | OHIO STATE BUCKEYES (6-17, 2-12, 0-8 Away)* | - | | | | |
