| November 15, 2042 | NEW HAMPSHIRE WILDCATS | W 99-79 | 1-0 | C. Hordemann 25 | J. Lytle 4 | R. Rowland 6 |
| November 19, 2042 | WESTERN KENTUCKY HILLTOPPERS | W 72-69 | 2-0 | J. Lytle 14 | J. Howell 6 | J. Howell 8 |
| November 22, 2042 | GEORGE MASON PATRIOTS | W 74-65 | 3-0 | C. Hordemann 20 | C. Hordemann 4 | J. Akins 9 |
| November 26, 2042 | CHICAGO STATE COUGARS | W 90-74 | 4-0 | C. Hordemann 20 | J. Lytle 3 | J. Howell 8 |
| November 30, 2042 | CENTRAL ARKANSAS BEARS | W 77-52 | 5-0 | C. Hordemann 16 | T. Noble 3 | J. Howell 7 |
| December 7, 2042 | LOUISIANA RAGIN' CAJUNS | W 96-61 | 6-0 | T. Forrest 23 | J. Lytle 5 | R. Rowland 9 |
| December 13, 2042 | #21 SETON HALL PIRATES | W 85-77 | 7-0 | C. Hordemann 35 | C. Hordemann 3 | J. Lytle 7 |
| December 16, 2042 | SAINT JOSEPH'S HAWKS Bad Boy Mowers Battle 4 Atlantis | L 86-90 | 7-1 | C. Hordemann 27 | C. Hordemann 4 | J. Howell 7 |
| December 21, 2042 | ABILENE CHRISTIAN WILDCATS | W 81-65 | 8-1 | J. Howell 20 | C. Hordemann 5 | J. Howell 10 |
| December 26, 2042 | @ Purdue Boilermakers (10-1, 0-0, 7-1 Home)* | - | | | | |
| December 28, 2042 | @ Oregon Ducks (4-5, 0-0, 4-2 Home)* | - | | | | |
| January 2, 2043 | INDIANA HOOSIERS (7-4, 0-0, 1-3 Away)* | - | | | | |
| January 4, 2043 | @ Michigan State Spartans (7-3, 0-0, 4-0 Home)* | - | | | | |
| January 9, 2043 | @ Minnesota Golden Gophers (9-2, 0-0, 5-1 Home)* | - | | | | |
| January 11, 2043 | NORTHWESTERN WILDCATS (5-6, 0-0, 1-2 Away)* | - | | | | |
| January 16, 2043 | @ USC Trojans (8-2, 0-0, 6-0 Home)* | - | | | | |
| January 18, 2043 | @ Ohio State Buckeyes (4-5, 0-0, 4-3 Home)* | - | | | | |
| January 23, 2043 | @ Wisconsin Badgers (5-4, 0-0, 5-2 Home)* | - | | | | |
| January 25, 2043 | @ Illinois Fighting Illini (7-2, 0-0, 5-0 Home)* | - | | | | |
| January 30, 2043 | IOWA HAWKEYES (9-1, 0-0, 3-1 Away)* | - | | | | |
| February 1, 2043 | PENN STATE NITTANY LIONS (6-3, 0-0, 1-2 Away)* | - | | | | |
| February 6, 2043 | WASHINGTON HUSKIES (3-6, 0-0, 0-3 Away)* | - | | | | |
| February 8, 2043 | @ Maryland Terrapins (7-3, 0-0, 5-0 Home)* | - | | | | |
| February 13, 2043 | MICHIGAN WOLVERINES (4-5, 0-0, 0-2 Away)* | - | | | | |
| February 15, 2043 | NEBRASKA CORNHUSKERS (3-6, 0-0, 0-2 Away)* | - | | | | |
| February 20, 2043 | @ UCLA Bruins (5-5, 0-0, 4-3 Home)* | - | | | | |
| February 22, 2043 | PURDUE BOILERMAKERS (10-1, 0-0, 0-0 Away)* | - | | | | |
| February 27, 2043 | ILLINOIS FIGHTING ILLINI (7-2, 0-0, 2-2 Away)* | - | | | | |
| March 1, 2043 | OHIO STATE BUCKEYES (4-5, 0-0, 0-1 Away)* | - | | | | |
