| November 15, 2042 | UMASS LOWELL RIVER HAWKS | W 80-61 | 1-0 | E. McWilliams 16 | J. Vaughn 5 | E. McWilliams 9 |
| November 18, 2042 | GEORGE MASON PATRIOTS | L 71-84 | 1-1 | K. Couch 14 | J. Vaughn 4 | M. Beal 7 |
| November 22, 2042 | UC IRVINE ANTEATERS | L 53-63 | 1-2 | M. Beal 16 | A. Tharp 3 | M. Beal 8 |
| November 25, 2042 | @ Toledo Rockets | L 59-67 | 1-3 | M. Beal 12 | A. Harris 7 | A. Harris 6 |
| November 29, 2042 | @ Cleveland State Vikings | L 72-77 | 1-4 | K. Couch 26 | J. Vaughn 5 | J. Vaughn 7 |
| December 3, 2042 | NORTH TEXAS MEAN GREEN | W 85-62 | 2-4 | K. Couch 22 | A. Tharp 5 | J. Vaughn 10 |
| December 5, 2042 | CANISIUS GOLDEN GRIFFINS | W 86-72 | 3-4 | M. Beal 27 | J. Vaughn 4 | M. Beal 11 |
| December 13, 2042 | @ SIU Edwardsville Cougars | L 85-102 | 3-5 | K. Couch 23 | J. Vaughn 6 | M. Beal 11 |
| December 20, 2042 | BOWLING GREEN FALCONS | W 78-62 | 4-5 | M. Beal 25 | J. Vaughn 5 | E. McWilliams 8 |
| December 26, 2042 | @ Valparaiso Crusaders* | L 68-80 | 4-6 | E. McWilliams 18 | A. Tharp 5 | J. Vaughn 10 |
| December 29, 2042 | @ Murray State Racers* | W 78-59 | 5-6 | S. Gagnon 20 | A. Tharp 3 | M. Beal 10 |
| January 2, 2043 | DRAKE BULLDOGS* | W 80-61 | 6-6 | A. Tharp 19 | A. Tharp 11 | M. Beal 11 |
| January 5, 2043 | EVANSVILLE PURPLE ACES* | L 61-69 | 6-7 | K. Couch 13 | A. Tharp 6 | E. McWilliams 10 |
| January 9, 2043 | NORTHERN IOWA PANTHERS* | L 75-83 | 6-8 | E. McWilliams 19 | J. Vaughn 4 | J. Vaughn 7 |
| January 12, 2043 | @ Illinois State Redbirds* | L 60-73 | 6-9 | K. Couch 16 | M. Beal 4 | E. McWilliams 10 |
| January 16, 2043 | @ Belmont Bruins* | W 76-73 | 7-9 | E. McWilliams 22 | A. Tharp 5 | J. Vaughn 9 |
| January 19, 2043 | INDIANA STATE SYCAMORES* | W 86-77 | 8-9 | K. Couch 25 | E. McWilliams 8 | M. Beal 11 |
| January 23, 2043 | MISSOURI STATE BEARS* | W 67-61 | 9-9 | K. Couch 15 | K. Couch 4 | K. Couch 8 |
| January 26, 2043 | BRADLEY BRAVES* | L 71-87 | 9-10 | K. Couch 18 | A. Tharp 6 | M. Beal 9 |
| January 30, 2043 | @ Indiana State Sycamores* | L 75-90 | 9-11 | K. Couch 26 | A. Tharp 6 | S. Gagnon 10 |
| February 2, 2043 | @ Missouri State Bears* | W 87-72 | 10-11 | K. Couch 24 | A. Tharp 5 | M. Beal 9 |
| February 6, 2043 | ILLINOIS STATE REDBIRDS* | L 70-80 | 10-12 | M. Beal 15 | A. Tharp 5 | M. Beal 9 |
| February 9, 2043 | BELMONT BRUINS* | W 86-56 | 11-12 | M. Beal 18 | A. Tharp 6 | M. Beal 14 |
| February 13, 2043 | @ Drake Bulldogs* | L 70-75 | 11-13 | E. McWilliams 18 | E. McWilliams 7 | M. Beal 9 |
| February 16, 2043 | @ Evansville Purple Aces* | W 78-60 | 12-13 | E. McWilliams 20 | A. Tharp 6 | E. McWilliams 10 |
| February 20, 2043 | VALPARAISO CRUSADERS* | W 83-57 | 13-13 | E. McWilliams 22 | K. Couch 6 | A. Tharp 8 |
| February 23, 2043 | MURRAY STATE RACERS* | L 52-66 | 13-14 | E. McWilliams 16 | K. Couch 5 | S. Gagnon 8 |
| February 27, 2043 | @ Bradley Braves* | L 58-79 | 13-15 | E. McWilliams 15 | A. Tharp 7 | E. McWilliams 11 |
| March 2, 2043 | @ UIC Flames* | W 95-69 | 14-15 | E. McWilliams 31 | A. Tharp 10 | E. McWilliams 9 |
| March 6, 2043 | NORTHERN IOWA PANTHERS MVC Tournament | L 62-81 | 14-16 | E. McWilliams 11 | A. Tharp 5 | M. Beal 11 |
