| November 16, 2042 | COLGATE RAIDERS | W 96-85 | 1-0 | C. Cameron 24 | C. Cameron 4 | J. Chang 7 |
| November 19, 2042 | SOUTH ALABAMA JAGUARS | W 81-59 | 2-0 | M. Harrison 18 | C. Cameron 10 | S. Goyman 15 |
| November 23, 2042 | ALABAMA STATE HORNETS | W 101-71 | 3-0 | C. Cameron 19 | C. Cameron 6 | R. Sprague 6 |
| November 26, 2042 | CAL ST. NORTHRIDGE MATADORS | W 75-64 | 4-0 | C. Cameron 24 | O. Cottrell 5 | J. Chang 10 |
| November 30, 2042 | AMERICAN EAGLES | W 67-50 | 5-0 | B. Madsen 20 | C. Cameron 6 | B. Madsen 11 |
| December 3, 2042 | CENTRAL MICHIGAN CHIPPEWAS | W 88-79 | 6-0 | K. Ng 25 | C. Cameron 4 | S. Goyman 6 |
| December 7, 2042 | HOLY CROSS CRUSADERS | W 86-69 | 7-0 | C. Cameron 24 | K. Ng 5 | B. Madsen 6 |
| December 13, 2042 | @ Rutgers Scarlet Knights | L 77-85 | 7-1 | K. Ng 23 | C. Cameron 12 | B. Madsen 10 |
| December 21, 2042 | FAIRFIELD STAGS | W 85-60 | 8-1 | K. Ng 19 | C. Cameron 5 | S. Goyman 10 |
| December 26, 2042 | CONNECTICUT HUSKIES* | W 89-66 | 9-1 | K. Ng 19 | C. Cameron 7 | R. Sprague 7 |
| December 28, 2042 | @ #24 Butler Bulldogs* | L 80-94 | 9-2 | C. Cameron 16 | C. Cameron 9 | M. Harrison 10 |
| December 30, 2042 | @ Providence Friars* | W 84-83 | 10-2 | C. Cameron 23 | C. Cameron 6 | R. Sprague 9 |
| January 2, 2043 | VILLANOVA WILDCATS* | W 90-61 | 11-2 | M. Harrison 20 | C. Cameron 10 | K. Newell 10 |
| January 4, 2043 | @ DePaul Blue Demons* | L 68-81 | 11-3 | K. Ng 17 | J. Townes 7 | M. Harrison 10 |
| January 6, 2043 | #18 CREIGHTON BLUE JAYS* | W 83-69 | 12-3 | K. Ng 20 | C. Cameron 5 | K. Newell 9 |
| January 13, 2043 | XAVIER MUSKETEERS* | W 98-73 | 13-3 | C. Cameron 19 | M. Harrison 6 | K. Newell 8 |
| January 18, 2043 | @ Georgetown Hoyas* | L 69-78 | 13-4 | M. Harrison 22 | J. Townes 4 | S. Goyman 7 |
| January 20, 2043 | @ St. John's Red Storm* | W 95-77 | 14-4 | C. Cameron 16 | C. Cameron 6 | K. Newell 10 |
| January 27, 2043 | MARQUETTE GOLDEN EAGLES* | W 75-57 | 15-4 | S. Goyman 15 | C. Cameron 6 | M. Harrison 9 |
| February 1, 2043 | DEPAUL BLUE DEMONS* | W 73-54 | 16-4 | K. Ng 16 | C. Cameron 7 | K. Newell 15 |
| February 3, 2043 | @ Xavier Musketeers* | L 100-104 OT | 16-5 | C. Cameron 19 | C. Cameron 6 | K. Newell 9 |
| February 8, 2043 | ST. JOHN'S RED STORM* | W 85-78 | 17-5 | B. Madsen 21 | C. Cameron 4 | M. Harrison 7 |
| February 10, 2043 | GEORGETOWN HOYAS* | L 79-80 | 17-6 | K. Ng 27 | C. Cameron 6 | K. Ng 8 |
| February 15, 2043 | @ #23 Creighton Blue Jays* | W 93-87 | 18-6 | K. Ng 18 | C. Cameron 8 | K. Newell 10 |
| February 17, 2043 | @ Marquette Golden Eagles* | W 83-80 | 19-6 | C. Cameron 18 | C. Cameron 7 | M. Harrison 8 |
| February 22, 2043 | @ Villanova Wildcats (9-17, 4-13, 8-6 Home)* | - | | | | |
| February 24, 2043 | @ Connecticut Huskies (16-12, 9-8, 10-3 Home)* | - | | | | |
| March 1, 2043 | PROVIDENCE FRIARS (9-16, 5-11, 3-8 Away)* | - | | | | |
| March 3, 2043 | BUTLER BULLDOGS (22-4, 16-0, 9-2 Away)* | - | | | | |
