| November 15, 2042 | @ Cleveland State Vikings | L 62-72 | 0-1 | T. Wagner 16 | A. Harrison 5 | W. Winter 7 |
| November 18, 2042 | @ Southern Jaguars | W 100-81 | 1-1 | J. Banuelos 24 | R. Grace 6 | W. Winter 9 |
| November 21, 2042 | @ Pittsburgh Panthers Charleston Classic | L 74-79 | 1-2 | T. Wagner 13 | J. Banuelos 4 | W. Winter 11 |
| November 25, 2042 | WESTERN CAROLINA CATAMOUNTS | W 83-70 | 2-2 | M. Boxler 19 | A. Harrison 6 | T. Wagner 7 |
| November 28, 2042 | @ Oklahoma State Cowboys | L 83-94 | 2-3 | J. Banuelos 24 | A. Harrison 5 | M. Boxler 8 |
| December 2, 2042 | @ Texas Southern Tigers | W 97-80 | 3-3 | J. Banuelos 24 | A. Harrison 4 | T. Wagner 8 |
| December 7, 2042 | HAMPTON PIRATES | W 95-73 | 4-3 | M. Boxler 20 | A. Harrison 5 | C. Robinson 9 |
| December 10, 2042 | @ #9 Wichita State Shockers | L 66-83 | 4-4 | J. Banuelos 14 | A. Harrison 6 | W. Winter 7 |
| December 13, 2042 | SOUTHERN ILLINOIS SALUKIS | W 102-85 | 5-4 | M. Boxler 26 | A. Harrison 6 | T. Wagner 7 |
| December 20, 2042 | @ Queens Royals | W 87-74 | 6-4 | K. Tyndell 16 | T. Wagner 6 | T. Wagner 9 |
| December 27, 2042 | @ Temple Owls | W 76-57 | 7-4 | J. Banuelos 20 | A. Harrison 8 | M. Boxler 13 |
| January 2, 2043 | @ Southern Indiana Screaming Eagles* | L 77-79 OT | 7-5 | M. Boxler 20 | M. Boxler 3 | M. Boxler 12 |
| January 4, 2043 | WESTERN ILLINOIS LEATHERNECKS* | W 90-72 | 8-5 | T. Wagner 20 | A. Harrison 9 | T. Wagner 11 |
| January 9, 2043 | @ Morehead State Eagles* | W 97-77 | 9-5 | J. Banuelos 17 | A. Harrison 6 | T. Wagner 9 |
| January 11, 2043 | @ UT Martin Skyhawks* | L 84-86 | 9-6 | T. Wagner 22 | A. Harrison 5 | W. Winter 7 |
| January 16, 2043 | @ Eastern Illinois Panthers* | L 71-86 | 9-7 | M. Boxler 19 | A. Harrison 8 | W. Winter 9 |
| January 18, 2043 | @ Western Illinois Leathernecks* | L 67-70 | 9-8 | T. Wagner 15 | J. Banuelos 5 | M. Boxler 10 |
| January 23, 2043 | TENNESSEE STATE TIGERS* | W 80-68 | 10-8 | J. Banuelos 18 | A. Harrison 6 | M. Boxler 8 |
| January 27, 2043 | @ SE Missouri State Redhawks* | L 87-94 OT | 10-9 | J. Banuelos 26 | A. Harrison 9 | W. Winter 9 |
| January 30, 2043 | TENNESSEE TECH GOLDEN EAGLES* | W 86-69 | 11-9 | W. Winter 13 | A. Harrison 4 | K. Tyndell 11 |
| February 3, 2043 | LINDENWOOD LIONS* | W 89-51 | 12-9 | M. Boxler 21 | A. Harrison 7 | T. Wagner 8 |
| February 8, 2043 | LITTLE ROCK TROJANS* | W 83-74 | 13-9 | J. Banuelos 17 | A. Harrison 7 | M. Boxler 11 |
| February 10, 2043 | SE MISSOURI STATE REDHAWKS* | W 83-78 | 14-9 | C. Robinson 17 | A. Harrison 5 | M. Boxler 9 |
| February 15, 2043 | EASTERN ILLINOIS PANTHERS* | W 95-73 | 15-9 | J. Banuelos 18 | A. Harrison 5 | W. Winter 9 |
| February 17, 2043 | UT MARTIN SKYHAWKS* | W 78-71 | 16-9 | W. Winter 17 | J. Banuelos 5 | W. Winter 9 |
| February 20, 2043 | @ Lindenwood Lions* | L 71-81 | 16-10 | M. Boxler 17 | A. Harrison 5 | W. Winter 5 |
| February 22, 2043 | @ Tennessee State Tigers* | W 104-89 | 17-10 | T. Wagner 26 | A. Harrison 8 | T. Wagner 10 |
| February 27, 2043 | @ Tennessee Tech Golden Eagles* | W 87-82 OT | 18-10 | W. Winter 14 | A. Harrison 9 | T. Wagner 8 |
| March 1, 2043 | MOREHEAD STATE EAGLES* | W 81-80 | 19-10 | M. Boxler 17 | A. Harrison 6 | J. Banuelos 5 |
| March 6, 2043 | SOUTHERN INDIANA SCREAMING EAGLES OVC Tournament | W 79-64 | 20-10 | J. Banuelos 21 | A. Harrison 7 | M. Boxler 11 |
| March 7, 2043 | @ SE Missouri State Redhawks OVC Tournament | W 78-64 | 21-10 | T. Wagner 16 | A. Harrison 6 | W. Winter 13 |
| March 8, 2043 | @ Tennessee State Tigers OVC Tournament | W 85-77 | 22-10 | M. Boxler 20 | A. Harrison 5 | M. Boxler 16 |
| March 16, 2043 | @ #7 Purdue Boilermakers NCAA Tournament | L 53-68 | 22-11 | C. Robinson 17 | A. Harrison 8 | T. Wagner 7 |
