| November 16, 2042 | FLORIDA A&M RATTLERS | W 79-60 | 1-0 | B. Crane 18 | R. Lane 5 | A. Wallace 10 |
| November 19, 2042 | WRIGHT STATE RAIDERS | W 91-78 | 2-0 | R. Lane 18 | R. Lane 5 | B. Crane 10 |
| November 21, 2042 | @ South Carolina Gamecocks Hall of Fame Classic | W 79-65 | 3-0 | B. Crane 20 | R. Lane 4 | L. McDowell 7 |
| November 22, 2042 | @ Oregon State Beavers Hall of Fame Classic | W 88-77 | 4-0 | V. Priest 16 | L. McDowell 4 | L. McDowell 7 |
| November 23, 2042 | @ #11 West Virginia Mountaineers Hall of Fame Classic | L 79-98 | 4-1 | V. Priest 23 | R. Lane 9 | A. Wallace 7 |
| November 26, 2042 | PITTSBURGH PANTHERS | W 66-63 | 5-1 | B. Crane 18 | E. Ward 4 | A. Wallace 9 |
| November 29, 2042 | @ UMass Minutemen | L 84-90 | 5-2 | B. Piper 15 | E. Ward 5 | L. McDowell 8 |
| December 3, 2042 | TENNESSEE STATE TIGERS | W 76-65 | 6-2 | L. Fisher 15 | R. Lane 4 | A. Wallace 7 |
| December 7, 2042 | @ NC State Wolfpack | L 55-75 | 6-3 | A. Wallace 10 | R. Lane 5 | L. McDowell 10 |
| December 13, 2042 | @ LIU Sharks | L 68-75 | 6-4 | B. Piper 13 | E. Ward 4 | A. Wallace 8 |
| December 21, 2042 | VIRGINIA CAVALIERS | L 79-90 | 6-5 | B. Crane 16 | R. Lane 7 | B. Crane 11 |
| December 26, 2042 | XAVIER MUSKETEERS (8-2, 0-0, 1-1 Away)* | - | | | | |
| December 30, 2042 | @ Villanova Wildcats (5-4, 0-0, 4-2 Home)* | - | | | | |
| January 2, 2043 | DEPAUL BLUE DEMONS (3-7, 0-0, 0-1 Away)* | - | | | | |
| January 4, 2043 | PROVIDENCE FRIARS (4-5, 0-0, 1-2 Away)* | - | | | | |
| January 6, 2043 | @ Connecticut Huskies (7-4, 0-0, 4-1 Home)* | - | | | | |
| January 11, 2043 | GEORGETOWN HOYAS (2-8, 0-0, 0-6 Away)* | - | | | | |
| January 13, 2043 | @ Creighton Blue Jays (9-2, 0-0, 3-1 Home)* | - | | | | |
| January 18, 2043 | MARQUETTE GOLDEN EAGLES (5-4, 0-0, 1-1 Away)* | - | | | | |
| January 20, 2043 | SETON HALL PIRATES (8-1, 0-0, 0-1 Away)* | - | | | | |
| January 25, 2043 | @ Butler Bulldogs (6-4, 0-0, 4-1 Home)* | - | | | | |
| January 27, 2043 | @ Providence Friars (4-5, 0-0, 3-2 Home)* | - | | | | |
| February 1, 2043 | CONNECTICUT HUSKIES (7-4, 0-0, 1-2 Away)* | - | | | | |
| February 3, 2043 | VILLANOVA WILDCATS (5-4, 0-0, 1-1 Away)* | - | | | | |
| February 8, 2043 | @ Seton Hall Pirates (8-1, 0-0, 8-0 Home)* | - | | | | |
| February 10, 2043 | @ Marquette Golden Eagles (5-4, 0-0, 4-2 Home)* | - | | | | |
| February 17, 2043 | BUTLER BULLDOGS (6-4, 0-0, 1-2 Away)* | - | | | | |
| February 22, 2043 | CREIGHTON BLUE JAYS (9-2, 0-0, 3-1 Away)* | - | | | | |
| February 27, 2043 | @ Georgetown Hoyas (2-8, 0-0, 1-1 Home)* | - | | | | |
| March 1, 2043 | @ Xavier Musketeers (8-2, 0-0, 6-0 Home)* | - | | | | |
| March 3, 2043 | @ DePaul Blue Demons (3-7, 0-0, 2-5 Home)* | - | | | | |
