| November 16, 2042 | FLORIDA A&M RATTLERS | W 79-60 | 1-0 | B. Crane 18 | R. Lane 5 | A. Wallace 10 |
| November 19, 2042 | WRIGHT STATE RAIDERS | W 91-78 | 2-0 | R. Lane 18 | R. Lane 5 | B. Crane 10 |
| November 21, 2042 | @ South Carolina Gamecocks Hall of Fame Classic | W 79-65 | 3-0 | B. Crane 20 | R. Lane 4 | L. McDowell 7 |
| November 22, 2042 | @ Oregon State Beavers Hall of Fame Classic | W 88-77 | 4-0 | V. Priest 16 | L. McDowell 4 | L. McDowell 7 |
| November 23, 2042 | @ #11 West Virginia Mountaineers Hall of Fame Classic | L 79-98 | 4-1 | V. Priest 23 | R. Lane 9 | A. Wallace 7 |
| November 26, 2042 | PITTSBURGH PANTHERS | W 66-63 | 5-1 | B. Crane 18 | E. Ward 4 | A. Wallace 9 |
| November 29, 2042 | @ UMass Minutemen | L 84-90 | 5-2 | B. Piper 15 | E. Ward 5 | L. McDowell 8 |
| December 3, 2042 | TENNESSEE STATE TIGERS | W 76-65 | 6-2 | L. Fisher 15 | R. Lane 4 | A. Wallace 7 |
| December 7, 2042 | @ NC State Wolfpack | L 55-75 | 6-3 | A. Wallace 10 | R. Lane 5 | L. McDowell 10 |
| December 13, 2042 | @ LIU Sharks | L 68-75 | 6-4 | B. Piper 13 | E. Ward 4 | A. Wallace 8 |
| December 21, 2042 | VIRGINIA CAVALIERS | L 79-90 | 6-5 | B. Crane 16 | R. Lane 7 | B. Crane 11 |
| December 26, 2042 | #25 XAVIER MUSKETEERS* | L 88-102 | 6-6 | A. Wallace 19 | R. Lane 3 | L. McDowell 6 |
| December 30, 2042 | @ Villanova Wildcats* | L 71-73 | 6-7 | V. Priest 16 | A. Wallace 6 | R. Lane 9 |
| January 2, 2043 | DEPAUL BLUE DEMONS* | L 91-96 | 6-8 | V. Priest 14 | R. Lane 9 | A. Wallace 7 |
| January 4, 2043 | PROVIDENCE FRIARS* | W 76-73 | 7-8 | L. McDowell 12 | R. Lane 6 | B. Crane 9 |
| January 6, 2043 | @ Connecticut Huskies* | L 67-90 | 7-9 | B. Crane 17 | V. Priest 5 | A. Wallace 7 |
| January 11, 2043 | GEORGETOWN HOYAS* | L 72-79 | 7-10 | B. Crane 16 | R. Lane 6 | A. Wallace 11 |
| January 13, 2043 | @ #23 Creighton Blue Jays* | L 58-82 | 7-11 | B. Crane 12 | R. Lane 4 | B. Crane 11 |
| January 18, 2043 | MARQUETTE GOLDEN EAGLES* | L 62-79 | 7-12 | R. Lane 8 | R. Lane 3 | B. Crane 7 |
| January 20, 2043 | #20 SETON HALL PIRATES* | L 77-95 | 7-13 | L. McDowell 17 | R. Lane 3 | L. McDowell 9 |
| January 25, 2043 | @ #12 Butler Bulldogs* | L 69-83 | 7-14 | A. Wallace 11 | R. Lane 7 | L. Fisher 7 |
| January 27, 2043 | @ Providence Friars* | L 75-90 | 7-15 | V. Priest 18 | R. Lane 7 | A. Wallace 11 |
| February 1, 2043 | CONNECTICUT HUSKIES* | W 76-62 | 8-15 | B. Crane 17 | R. Lane 8 | B. Crane 11 |
| February 3, 2043 | VILLANOVA WILDCATS* | W 84-79 | 9-15 | L. McDowell 16 | E. Ward 5 | A. Wallace 13 |
| February 8, 2043 | @ #23 Seton Hall Pirates* | L 78-85 | 9-16 | V. Priest 15 | R. Lane 4 | A. Wallace 10 |
| February 10, 2043 | @ Marquette Golden Eagles* | L 71-88 | 9-17 | R. Lane 14 | V. Priest 3 | B. Crane 6 |
| February 17, 2043 | BUTLER BULLDOGS (20-4, 14-0, 8-2 Away)* | - | | | | |
| February 22, 2043 | CREIGHTON BLUE JAYS (17-8, 8-6, 8-4 Away)* | - | | | | |
| February 27, 2043 | @ Georgetown Hoyas (8-17, 6-9, 4-5 Home)* | - | | | | |
| March 1, 2043 | @ Xavier Musketeers (13-11, 5-9, 9-3 Home)* | - | | | | |
| March 3, 2043 | @ DePaul Blue Demons (10-13, 7-6, 6-7 Home)* | - | | | | |
