| November 13, 2042 | PENNSYLVANIA QUAKERS | W 82-63 | 1-0 | M. Sullivan 18 | B. Irvin 8 | M. Sullivan 8 |
| November 16, 2042 | SAMFORD BULLDOGS | W 80-60 | 2-0 | B. Irvin 16 | B. Irvin 7 | M. Sullivan 10 |
| November 19, 2042 | GRAMBLING TIGERS | W 99-93 OT | 3-0 | B. Irvin 25 | T. Salgado 5 | T. Salgado 7 |
| November 21, 2042 | UCF KNIGHTS WSSN Classic | W 86-75 | 4-0 | J. Rowe 21 | B. Irvin 4 | T. Salgado 7 |
| November 22, 2042 | @ Miami (FL) Hurricanes WSSN Classic | L 66-94 | 4-1 | S. Lofton 13 | B. Irvin 7 | M. Sullivan 7 |
| November 26, 2042 | #7 NORTH CAROLINA TAR HEELS | L 71-86 | 4-2 | T. Salgado 20 | B. Irvin 8 | J. Rowe 5 |
| November 30, 2042 | ARKANSAS PINE BLUFF GOLDEN LIONS | L 68-74 | 4-3 | T. Salgado 23 | B. Irvin 4 | T. Salgado 6 |
| December 3, 2042 | COASTAL CAROLINA CHANTICLEERS | W 92-77 | 5-3 | T. Salgado 18 | B. Irvin 4 | S. Lofton 7 |
| December 5, 2042 | NORTHERN COLORADO BEARS | L 58-69 | 5-4 | T. Salgado 11 | T. Henson 3 | S. Lofton 10 |
| December 13, 2042 | @ Loyola Marymount Lions | L 68-84 | 5-5 | T. Salgado 28 | B. Irvin 4 | S. Lofton 6 |
| December 26, 2042 | WASHINGTON HUSKIES* | W 90-63 | 6-5 | B. Irvin 19 | B. Irvin 5 | T. Henson 6 |
| December 28, 2042 | #22 IOWA HAWKEYES* | W 61-53 | 7-5 | J. Rowe 16 | B. Irvin 5 | M. Sullivan 6 |
| January 2, 2043 | @ Wisconsin Badgers* | L 54-82 | 7-6 | T. Salgado 19 | B. Irvin 6 | S. Lofton 6 |
| January 4, 2043 | @ #9 Maryland Terrapins* | L 53-72 | 7-7 | T. Salgado 14 | R. Ford 5 | M. Sullivan 7 |
| January 9, 2043 | OHIO STATE BUCKEYES* | W 74-69 | 8-7 | T. Salgado 22 | B. Irvin 4 | M. Sullivan 7 |
| January 11, 2043 | USC TROJANS* | L 76-86 | 8-8 | B. Irvin 15 | S. Lofton 4 | S. Lofton 7 |
| January 16, 2043 | @ #6 Minnesota Golden Gophers* | L 72-81 | 8-9 | J. Rowe 17 | B. Irvin 4 | T. Salgado 14 |
| January 18, 2043 | INDIANA HOOSIERS* | L 72-83 | 8-10 | T. Salgado 22 | B. Irvin 10 | J. Rowe 4 |
| January 23, 2043 | @ Nebraska Cornhuskers* | L 73-83 | 8-11 | B. Irvin 21 | B. Irvin 5 | M. Sullivan 9 |
| January 25, 2043 | @ Michigan Wolverines* | L 67-79 | 8-12 | T. Salgado 19 | B. Irvin 4 | M. Sullivan 8 |
| January 30, 2043 | @ Oregon Ducks* | W 78-75 | 9-12 | B. Irvin 17 | B. Irvin 5 | T. Salgado 8 |
| February 1, 2043 | @ Michigan State Spartans* | L 60-84 | 9-13 | T. Salgado 23 | B. Irvin 2 | T. Henson 6 |
| February 6, 2043 | #8 PURDUE BOILERMAKERS* | L 68-91 | 9-14 | T. Salgado 15 | J. Rowe 4 | T. Salgado 5 |
| February 8, 2043 | PENN STATE NITTANY LIONS* | L 71-83 | 9-15 | B. Irvin 14 | J. Rowe 3 | M. Sullivan 5 |
| February 13, 2043 | @ Northwestern Wildcats (12-13, 7-7, 6-6 Home)* | - | | | | |
| February 15, 2043 | @ Illinois Fighting Illini (16-7, 9-5, 12-1 Home)* | - | | | | |
| February 20, 2043 | RUTGERS SCARLET KNIGHTS (11-12, 3-11, 1-8 Away)* | - | | | | |
| February 22, 2043 | MARYLAND TERRAPINS (16-8, 9-5, 6-5 Away)* | - | | | | |
| February 27, 2043 | @ Washington Huskies (5-18, 2-12, 5-6 Home)* | - | | | | |
| March 1, 2043 | WISCONSIN BADGERS (11-12, 6-8, 0-8 Away)* | - | | | | |
