| November 16, 2042 | WESTERN KENTUCKY HILLTOPPERS | L 70-73 | 0-1 | R. Partridge 19 | C. Austin 8 | R. Partridge 8 |
| November 19, 2042 | NORTH DAKOTA FIGHTING HAWKS | W 83-77 OT | 1-1 | R. Partridge 25 | C. Austin 6 | R. Partridge 7 |
| November 22, 2042 | ALABAMA CRIMSON TIDE | L 64-66 OT | 1-2 | B. Ross 23 | C. Austin 5 | D. Augustine 10 |
| November 25, 2042 | NORTHERN KENTUCKY NORSE ESPN Events Invitational | W 87-81 | 2-2 | W. Matson 23 | C. Austin 11 | W. Matson 12 |
| November 26, 2042 | BUCKNELL BISON ESPN Events Invitational | L 72-75 | 2-3 | B. Ross 18 | C. Austin 3 | W. Matson 10 |
| November 30, 2042 | AUSTIN PEAY GOVERNORS | W 71-50 | 3-3 | B. Ross 24 | C. Austin 7 | W. Matson 12 |
| December 7, 2042 | @ #3 Minnesota Golden Gophers | L 64-73 | 3-4 | B. Ross 19 | B. Ross 4 | D. Augustine 10 |
| December 10, 2042 | WESTERN CAROLINA CATAMOUNTS | W 75-71 | 4-4 | B. Ross 23 | C. Austin 8 | B. Ross 8 |
| December 13, 2042 | @ Ohio State Buckeyes | L 73-84 | 4-5 | W. Matson 18 | B. Ross 4 | D. Augustine 7 |
| December 20, 2042 | VANDERBILT COMMODORES | L 81-92 | 4-6 | D. Augustine 22 | C. Austin 6 | D. Augustine 7 |
| December 26, 2042 | @ Georgia Tech Yellow Jackets* | L 69-79 | 4-7 | B. Ross 15 | D. Augustine 4 | D. Augustine 9 |
| December 28, 2042 | @ NC State Wolfpack* | L 58-74 | 4-8 | B. Ross 17 | C. Austin 6 | D. Augustine 12 |
| January 2, 2043 | @ Virginia Cavaliers* | L 64-80 | 4-9 | D. Augustine 15 | C. Austin 8 | W. Matson 7 |
| January 4, 2043 | #7 STANFORD CARDINAL* | L 74-82 | 4-10 | R. Partridge 18 | C. Austin 8 | C. Austin 7 |
| January 9, 2043 | CLEMSON TIGERS* | L 52-64 | 4-11 | R. Partridge 11 | C. Austin 5 | D. Augustine 8 |
| January 11, 2043 | @ California Golden Bears* | L 70-77 | 4-12 | B. Ross 18 | C. Austin 6 | W. Matson 10 |
| January 16, 2043 | @ Miami (FL) Hurricanes* | L 51-69 | 4-13 | R. Partridge 9 | B. Ross 3 | D. Augustine 7 |
| January 18, 2043 | #14 NOTRE DAME FIGHTING IRISH* | L 78-89 | 4-14 | E. Vasquez 20 | C. Austin 13 | R. Partridge 8 |
| January 23, 2043 | SMU MUSTANGS* | L 66-91 | 4-15 | E. Vasquez 12 | C. Austin 7 | D. Augustine 12 |
| January 25, 2043 | @ Duke Blue Devils* | L 63-87 | 4-16 | B. Ross 19 | C. Austin 4 | B. Ross 7 |
| January 30, 2043 | @ Florida State Seminoles* | L 48-71 | 4-17 | B. Ross 13 | D. Augustine 4 | C. Austin 4 |
| February 1, 2043 | #1 NORTH CAROLINA TAR HEELS* | L 50-77 | 4-18 | R. Partridge 10 | C. Austin 4 | B. Ross 9 |
| February 6, 2043 | @ Boston College Eagles* | L 69-89 | 4-19 | C. Camby 17 | C. Austin 7 | B. Ross 8 |
| February 8, 2043 | SYRACUSE ORANGE* | L 70-84 | 4-20 | R. Partridge 19 | B. Ross 7 | B. Ross 6 |
| February 13, 2043 | WAKE FOREST DEMON DEACONS (6-18, 3-11, 2-9 Away)* | - | | | | |
| February 15, 2043 | LOUISVILLE CARDINALS (15-10, 6-8, 4-5 Away)* | - | | | | |
| February 20, 2043 | @ Pittsburgh Panthers (15-10, 8-6, 9-4 Home)* | - | | | | |
| February 22, 2043 | @ Stanford Cardinal (20-6, 9-5, 11-2 Home)* | - | | | | |
| February 27, 2043 | CALIFORNIA GOLDEN BEARS (7-16, 6-8, 0-9 Away)* | - | | | | |
| March 1, 2043 | PITTSBURGH PANTHERS (15-10, 8-6, 3-6 Away)* | - | | | | |
