| November 14, 2042 | @ #25 Oklahoma State Cowboys | L 58-81 | 0-1 | C. Harris 14 | G. Banks 4 | J. Kimmel 10 |
| November 19, 2042 | BRYANT BULLDOGS | W 87-81 | 1-1 | C. Harris 22 | G. Banks 3 | C. Harris 9 |
| November 22, 2042 | @ Texas Longhorns | L 70-92 | 1-2 | L. Ransom 16 | G. Banks 5 | J. Kimmel 7 |
| November 24, 2042 | @ #1 Baylor Bears | L 58-68 | 1-3 | E. Henry 12 | C. Harris 7 | J. Kimmel 9 |
| December 6, 2042 | TENNESSEE VOLUNTEERS | L 78-83 | 1-4 | M. Sweeney 19 | C. Harris 5 | M. Sweeney 8 |
| December 9, 2042 | GEORGIA SOUTHERN EAGLES Baha Mar Hoops Bahamas Championship | L 72-84 | 1-5 | E. Henry 14 | G. Banks 5 | C. Harris 6 |
| December 13, 2042 | @ Connecticut Huskies | L 65-79 | 1-6 | M. Adams 18 | C. Harris 5 | E. Henry 6 |
| December 17, 2042 | BUTLER BULLDOGS | L 62-96 | 1-7 | E. Henry 10 | C. Harris 4 | C. Harris 7 |
| December 21, 2042 | @ St. John's Red Storm | W 90-79 | 2-7 | C. Harris 17 | C. Harris 5 | J. Kimmel 7 |
| December 26, 2042 | MIAMI (FL) HURRICANES (9-2, 0-0, 2-1 Away)* | - | | | | |
| December 28, 2042 | @ Notre Dame Fighting Irish (8-4, 0-0, 4-1 Home)* | - | | | | |
| January 2, 2043 | VIRGINIA TECH HOKIES (4-6, 0-0, 0-2 Away)* | - | | | | |
| January 4, 2043 | @ North Carolina Tar Heels (10-1, 0-0, 5-0 Home)* | - | | | | |
| January 9, 2043 | DUKE BLUE DEVILS (5-4, 0-0, 1-2 Away)* | - | | | | |
| January 11, 2043 | @ Syracuse Orange (6-3, 0-0, 5-1 Home)* | - | | | | |
| January 16, 2043 | CALIFORNIA GOLDEN BEARS (1-8, 0-0, 0-3 Away)* | - | | | | |
| January 18, 2043 | @ NC State Wolfpack (6-3, 0-0, 6-0 Home)* | - | | | | |
| January 23, 2043 | @ Clemson Tigers (2-7, 0-0, 1-3 Home)* | - | | | | |
| January 25, 2043 | @ Wake Forest Demon Deacons (3-7, 0-0, 0-3 Home)* | - | | | | |
| January 30, 2043 | @ Georgia Tech Yellow Jackets (8-3, 0-0, 3-1 Home)* | - | | | | |
| February 1, 2043 | FLORIDA STATE SEMINOLES (7-2, 0-0, 0-2 Away)* | - | | | | |
| February 6, 2043 | PITTSBURGH PANTHERS (7-4, 0-0, 0-3 Away)* | - | | | | |
| February 8, 2043 | LOUISVILLE CARDINALS (9-2, 0-0, 3-0 Away)* | - | | | | |
| February 13, 2043 | STANFORD CARDINAL (11-1, 0-0, 1-1 Away)* | - | | | | |
| February 15, 2043 | @ SMU Mustangs (6-4, 0-0, 5-2 Home)* | - | | | | |
| February 20, 2043 | @ Boston College Eagles (3-6, 0-0, 2-3 Home)* | - | | | | |
| February 22, 2043 | @ Louisville Cardinals (9-2, 0-0, 4-1 Home)* | - | | | | |
| February 27, 2043 | WAKE FOREST DEMON DEACONS (3-7, 0-0, 2-3 Away)* | - | | | | |
| March 1, 2043 | SMU MUSTANGS (6-4, 0-0, 0-1 Away)* | - | | | | |
