| November 14, 2042 | @ #25 Oklahoma State Cowboys | L 58-81 | 0-1 | C. Harris 14 | G. Banks 4 | J. Kimmel 10 |
| November 19, 2042 | BRYANT BULLDOGS | W 87-81 | 1-1 | C. Harris 22 | G. Banks 3 | C. Harris 9 |
| November 22, 2042 | @ Texas Longhorns | L 70-92 | 1-2 | L. Ransom 16 | G. Banks 5 | J. Kimmel 7 |
| November 24, 2042 | @ #1 Baylor Bears | L 58-68 | 1-3 | E. Henry 12 | C. Harris 7 | J. Kimmel 9 |
| December 6, 2042 | TENNESSEE VOLUNTEERS | L 78-83 | 1-4 | M. Sweeney 19 | C. Harris 5 | M. Sweeney 8 |
| December 9, 2042 | GEORGIA SOUTHERN EAGLES Baha Mar Hoops Bahamas Championship | L 72-84 | 1-5 | E. Henry 14 | G. Banks 5 | C. Harris 6 |
| December 13, 2042 | @ Connecticut Huskies | L 65-79 | 1-6 | M. Adams 18 | C. Harris 5 | E. Henry 6 |
| December 17, 2042 | BUTLER BULLDOGS | L 62-96 | 1-7 | E. Henry 10 | C. Harris 4 | C. Harris 7 |
| December 21, 2042 | @ St. John's Red Storm | W 90-79 | 2-7 | C. Harris 17 | C. Harris 5 | J. Kimmel 7 |
| December 26, 2042 | #18 MIAMI (FL) HURRICANES* | W 82-72 | 3-7 | C. Harris 21 | C. Harris 5 | C. Harris 6 |
| December 28, 2042 | @ #15 Notre Dame Fighting Irish* | L 64-84 | 3-8 | M. Sweeney 21 | G. Banks 4 | J. Kimmel 7 |
| January 2, 2043 | VIRGINIA TECH HOKIES* | W 80-64 | 4-8 | C. Harris 15 | C. Harris 8 | E. Henry 7 |
| January 4, 2043 | @ #3 North Carolina Tar Heels* | L 71-90 | 4-9 | E. Henry 16 | G. Banks 5 | G. Banks 6 |
| January 9, 2043 | DUKE BLUE DEVILS* | W 90-67 | 5-9 | M. Sweeney 26 | C. Harris 5 | M. Sweeney 11 |
| January 11, 2043 | @ Syracuse Orange* | W 83-73 | 6-9 | M. Adams 17 | C. Harris 11 | J. Kimmel 7 |
| January 16, 2043 | CALIFORNIA GOLDEN BEARS* | W 80-73 | 7-9 | C. Harris 19 | J. Kimmel 4 | E. Henry 9 |
| January 18, 2043 | @ NC State Wolfpack* | L 46-53 | 7-10 | G. Banks 8 | C. Harris 4 | M. Adams 8 |
| January 23, 2043 | @ Clemson Tigers* | W 91-83 | 8-10 | C. Harris 21 | C. Harris 9 | E. Henry 10 |
| January 25, 2043 | @ Wake Forest Demon Deacons* | L 66-75 | 8-11 | G. Banks 13 | C. Harris 5 | C. Harris 5 |
| January 30, 2043 | @ Georgia Tech Yellow Jackets* | L 67-74 | 8-12 | M. Sweeney 17 | G. Banks 3 | J. Smalls 5 |
| February 1, 2043 | FLORIDA STATE SEMINOLES* | L 70-74 | 8-13 | G. Banks 14 | C. Harris 7 | C. Harris 6 |
| February 6, 2043 | PITTSBURGH PANTHERS* | W 74-64 | 9-13 | C. Harris 14 | C. Harris 5 | E. Henry 15 |
| February 8, 2043 | LOUISVILLE CARDINALS* | L 80-101 | 9-14 | C. Harris 23 | M. Adams 3 | C. Harris 6 |
| February 13, 2043 | STANFORD CARDINAL (20-6, 9-5, 5-4 Away)* | - | | | | |
| February 15, 2043 | @ SMU Mustangs (13-11, 7-7, 9-4 Home)* | - | | | | |
| February 20, 2043 | @ Boston College Eagles (7-16, 4-10, 5-7 Home)* | - | | | | |
| February 22, 2043 | @ Louisville Cardinals (15-10, 6-8, 9-4 Home)* | - | | | | |
| February 27, 2043 | WAKE FOREST DEMON DEACONS (6-18, 3-11, 2-9 Away)* | - | | | | |
| March 1, 2043 | SMU MUSTANGS (13-11, 7-7, 3-6 Away)* | - | | | | |
