| November 14, 2042 | @ #20 Saint Mary's Gaels NIT Season Tip-Off | L 54-85 | 0-1 | B. Barney 11 | B. Barney 2 | H. Andrews 11 |
| November 23, 2042 | @ Princeton Tigers | L 55-71 | 0-2 | J. Larkin 12 | G. O'Toole 3 | T. Braun 12 |
| November 24, 2042 | @ Oklahoma State Cowboys | L 55-100 | 0-3 | D. Eason 11 | T. Burton 6 | H. Andrews 7 |
| November 29, 2042 | @ Central Michigan Chippewas | L 73-85 | 0-4 | A. Kellogg 15 | J. Larkin 6 | T. Braun 8 |
| December 2, 2042 | SIENA SAINTS | L 68-71 | 0-5 | H. Andrews 11 | J. Larkin 8 | F. Crain 9 |
| December 6, 2042 | EASTERN KENTUCKY COLONELS | L 70-75 | 0-6 | G. O'Toole 15 | J. Larkin 7 | F. Crain 7 |
| December 9, 2042 | PURDUE FORT WAYNE MASTODONS | W 98-93 | 1-6 | G. O'Toole 31 | B. Barney 5 | G. O'Toole 7 |
| December 13, 2042 | @ Marist Red Foxes | L 63-78 | 1-7 | H. Andrews 11 | J. Larkin 5 | H. Andrews 10 |
| December 16, 2042 | @ Texas Tech Red Raiders | L 65-81 | 1-8 | G. O'Toole 12 | J. Larkin 3 | F. Crain 9 |
| December 20, 2042 | WRIGHT STATE RAIDERS | W 95-67 | 2-8 | A. Kellogg 22 | J. Larkin 7 | H. Andrews 6 |
| December 23, 2042 | HARVARD CRIMSON | W 87-66 | 3-8 | F. Crain 20 | J. Larkin 6 | F. Crain 11 |
| December 27, 2042 | @ Marshall Thundering Herd | L 74-88 | 3-9 | G. O'Toole 13 | J. Larkin 4 | H. Andrews 9 |
| December 30, 2042 | @ Mercyhurst Lakers | W 74-64 | 4-9 | H. Andrews 19 | J. Larkin 7 | F. Crain 9 |
| January 3, 2043 | @ Binghamton Bearcats* | L 80-93 | 4-10 | B. Barney 18 | J. Larkin 6 | L. Selby 6 |
| January 6, 2043 | NJIT HIGHLANDERS* | L 78-93 | 4-11 | A. Kellogg 19 | J. Larkin 7 | H. Andrews 10 |
| January 10, 2043 | @ Bryant Bulldogs* | W 88-77 | 5-11 | A. Kellogg 17 | J. Larkin 5 | F. Crain 8 |
| January 13, 2043 | NEW HAMPSHIRE WILDCATS* | W 69-66 | 6-11 | F. Crain 11 | J. Larkin 7 | T. Braun 6 |
| January 17, 2043 | @ Albany Great Danes* | W 78-67 | 7-11 | H. Andrews 15 | J. Larkin 4 | H. Andrews 10 |
| January 20, 2043 | UMBC RETRIEVERS* | W 84-63 | 8-11 | B. Barney 16 | H. Andrews 5 | H. Andrews 9 |
| January 24, 2043 | @ UMass Lowell River Hawks* | L 69-78 | 8-12 | J. Larkin 13 | J. Larkin 5 | F. Crain 10 |
| January 27, 2043 | MAINE BLACK BEARS* | W 84-62 | 9-12 | A. Kellogg 12 | T. Burton 8 | T. Braun 11 |
| February 3, 2043 | BINGHAMTON BEARCATS* | W 94-64 | 10-12 | B. Barney 21 | J. Larkin 6 | H. Andrews 7 |
| February 7, 2043 | @ NJIT Highlanders* | L 81-82 | 10-13 | B. Barney 33 | J. Larkin 9 | H. Andrews 12 |
| February 10, 2043 | BRYANT BULLDOGS* | W 86-70 | 11-13 | B. Barney 19 | J. Larkin 8 | B. Barney 5 |
| February 14, 2043 | @ New Hampshire Wildcats (9-15, 3-8, 5-2 Home)* | - | | | | |
| February 17, 2043 | ALBANY GREAT DANES (9-14, 3-7, 5-11 Away)* | - | | | | |
| February 21, 2043 | @ UMBC Retrievers (9-14, 6-4, 5-5 Home)* | - | | | | |
| February 24, 2043 | UMASS LOWELL RIVER HAWKS (9-15, 6-5, 2-14 Away)* | - | | | | |
| February 28, 2043 | @ Maine Black Bears (6-18, 2-9, 3-6 Home)* | - | | | | |
