| November 15, 2042 | TENNESSEE VOLUNTEERS | L 58-75 | 0-1 | K. Gutierrez 13 | H. Stern 5 | L. Duvall 8 |
| November 23, 2042 | @ Michigan Wolverines | W 84-75 | 1-1 | S. Greer 16 | K. Gutierrez 6 | K. Engle 8 |
| November 25, 2042 | WESTERN MICHIGAN BRONCOS | L 73-79 | 1-2 | K. Gutierrez 22 | H. Stern 6 | A. Sinclair 7 |
| November 30, 2042 | USC TROJANS | W 91-88 | 2-2 | K. Gutierrez 33 | H. Stern 7 | K. Engle 9 |
| December 2, 2042 | INDIANA STATE SYCAMORES | W 88-85 | 3-2 | K. Gutierrez 31 | H. Stern 5 | N. Ryan 9 |
| December 6, 2042 | #25 TEXAS LONGHORNS | W 82-72 | 4-2 | K. Schultz 19 | H. Stern 5 | K. Engle 6 |
| December 9, 2042 | @ Alabama Crimson Tide | L 46-64 | 4-3 | K. Schultz 19 | H. Stern 3 | N. Ryan 10 |
| December 13, 2042 | SAINT JOSEPH'S HAWKS | W 80-61 | 5-3 | K. Gutierrez 18 | H. Stern 7 | N. Ryan 8 |
| December 16, 2042 | TCU HORNED FROGS Diamond Head Classic | L 93-104 | 5-4 | K. Gutierrez 27 | H. Stern 10 | N. Ryan 6 |
| December 26, 2042 | @ Marquette Golden Eagles (5-4, 0-0, 4-2 Home)* | - | | | | |
| December 30, 2042 | ST. JOHN'S RED STORM (6-5, 0-0, 0-3 Away)* | - | | | | |
| January 2, 2043 | @ Seton Hall Pirates (8-1, 0-0, 8-0 Home)* | - | | | | |
| January 4, 2043 | CONNECTICUT HUSKIES (7-4, 0-0, 1-2 Away)* | - | | | | |
| January 6, 2043 | GEORGETOWN HOYAS (2-8, 0-0, 0-6 Away)* | - | | | | |
| January 11, 2043 | @ Butler Bulldogs (6-4, 0-0, 4-1 Home)* | - | | | | |
| January 13, 2043 | @ Providence Friars (4-5, 0-0, 3-2 Home)* | - | | | | |
| January 18, 2043 | CREIGHTON BLUE JAYS (9-2, 0-0, 3-1 Away)* | - | | | | |
| January 23, 2043 | @ Connecticut Huskies (7-4, 0-0, 4-1 Home)* | - | | | | |
| January 27, 2043 | XAVIER MUSKETEERS (8-2, 0-0, 1-1 Away)* | - | | | | |
| January 30, 2043 | DEPAUL BLUE DEMONS (3-7, 0-0, 0-1 Away)* | - | | | | |
| February 1, 2043 | @ Georgetown Hoyas (2-8, 0-0, 1-1 Home)* | - | | | | |
| February 3, 2043 | @ St. John's Red Storm (6-5, 0-0, 4-1 Home)* | - | | | | |
| February 8, 2043 | PROVIDENCE FRIARS (4-5, 0-0, 1-2 Away)* | - | | | | |
| February 10, 2043 | BUTLER BULLDOGS (6-4, 0-0, 1-2 Away)* | - | | | | |
| February 15, 2043 | @ Xavier Musketeers (8-2, 0-0, 6-0 Home)* | - | | | | |
| February 17, 2043 | @ DePaul Blue Demons (3-7, 0-0, 2-5 Home)* | - | | | | |
| February 22, 2043 | SETON HALL PIRATES (8-1, 0-0, 0-1 Away)* | - | | | | |
| February 24, 2043 | MARQUETTE GOLDEN EAGLES (5-4, 0-0, 1-1 Away)* | - | | | | |
| March 3, 2043 | @ Creighton Blue Jays (9-2, 0-0, 3-1 Home)* | - | | | | |
