| November 15, 2042 | TENNESSEE VOLUNTEERS | L 58-75 | 0-1 | K. Gutierrez 13 | H. Stern 5 | L. Duvall 8 |
| November 23, 2042 | @ Michigan Wolverines | W 84-75 | 1-1 | S. Greer 16 | K. Gutierrez 6 | K. Engle 8 |
| November 25, 2042 | WESTERN MICHIGAN BRONCOS | L 73-79 | 1-2 | K. Gutierrez 22 | H. Stern 6 | A. Sinclair 7 |
| November 30, 2042 | USC TROJANS | W 91-88 | 2-2 | K. Gutierrez 33 | H. Stern 7 | K. Engle 9 |
| December 2, 2042 | INDIANA STATE SYCAMORES | W 88-85 | 3-2 | K. Gutierrez 31 | H. Stern 5 | N. Ryan 9 |
| December 6, 2042 | #25 TEXAS LONGHORNS | W 82-72 | 4-2 | K. Schultz 19 | H. Stern 5 | K. Engle 6 |
| December 9, 2042 | @ Alabama Crimson Tide | L 46-64 | 4-3 | K. Schultz 19 | H. Stern 3 | N. Ryan 10 |
| December 13, 2042 | SAINT JOSEPH'S HAWKS | W 80-61 | 5-3 | K. Gutierrez 18 | H. Stern 7 | N. Ryan 8 |
| December 16, 2042 | TCU HORNED FROGS Diamond Head Classic | L 93-104 | 5-4 | K. Gutierrez 27 | H. Stern 10 | N. Ryan 6 |
| December 26, 2042 | @ Marquette Golden Eagles* | L 78-85 | 5-5 | K. Gutierrez 21 | H. Stern 7 | K. Gutierrez 5 |
| December 30, 2042 | ST. JOHN'S RED STORM* | W 73-71 | 6-5 | K. Gutierrez 23 | H. Stern 4 | K. Engle 9 |
| January 2, 2043 | @ #25 Seton Hall Pirates* | L 61-90 | 6-6 | H. Stern 12 | A. Sinclair 4 | L. Duvall 6 |
| January 4, 2043 | CONNECTICUT HUSKIES* | W 85-74 | 7-6 | K. Gutierrez 27 | H. Stern 5 | K. Engle 7 |
| January 6, 2043 | GEORGETOWN HOYAS* | L 68-80 | 7-7 | K. Gutierrez 14 | H. Stern 4 | K. Engle 11 |
| January 11, 2043 | @ #18 Butler Bulldogs* | L 60-88 | 7-8 | K. Engle 10 | H. Stern 6 | L. Duvall 7 |
| January 13, 2043 | @ Providence Friars* | L 94-102 | 7-9 | H. Stern 30 | S. Greer 6 | L. Duvall 8 |
| January 18, 2043 | #22 CREIGHTON BLUE JAYS* | L 76-79 | 7-10 | A. Sinclair 18 | H. Stern 7 | K. Engle 10 |
| January 23, 2043 | @ Connecticut Huskies* | L 79-89 | 7-11 | A. Sinclair 15 | H. Stern 4 | K. Engle 10 |
| January 27, 2043 | XAVIER MUSKETEERS* | W 82-74 | 8-11 | K. Gutierrez 23 | H. Stern 3 | K. Engle 6 |
| January 30, 2043 | DEPAUL BLUE DEMONS* | L 72-75 | 8-12 | K. Gutierrez 19 | H. Stern 7 | K. Engle 8 |
| February 1, 2043 | @ Georgetown Hoyas* | L 86-97 | 8-13 | H. Stern 21 | H. Stern 6 | N. Ryan 6 |
| February 3, 2043 | @ St. John's Red Storm* | L 79-84 | 8-14 | K. Schultz 17 | H. Stern 7 | N. Ryan 6 |
| February 8, 2043 | PROVIDENCE FRIARS* | W 91-67 | 9-14 | A. Sinclair 24 | H. Stern 8 | K. Engle 10 |
| February 10, 2043 | #10 BUTLER BULLDOGS* | L 60-81 | 9-15 | K. Schultz 15 | H. Stern 5 | H. Stern 6 |
| February 15, 2043 | @ Xavier Musketeers (13-11, 5-9, 9-3 Home)* | - | | | | |
| February 17, 2043 | @ DePaul Blue Demons (10-13, 7-6, 6-7 Home)* | - | | | | |
| February 22, 2043 | SETON HALL PIRATES (17-6, 9-5, 2-5 Away)* | - | | | | |
| February 24, 2043 | MARQUETTE GOLDEN EAGLES (14-10, 9-6, 5-5 Away)* | - | | | | |
| March 3, 2043 | @ Creighton Blue Jays (17-8, 8-6, 6-4 Home)* | - | | | | |
