| November 14, 2042 | DUQUESNE DUKES | W 84-50 | 1-0 | J. Nelson 23 | K. DeLong 5 | J. Nelson 21 |
| November 17, 2042 | GEORGIA SOUTHERN EAGLES | W 108-67 | 2-0 | O. Engel 20 | K. DeLong 6 | J. Nelson 12 |
| November 21, 2042 | UNC GREENSBORO SPARTANS Hall of Fame Classic | W 70-43 | 3-0 | D. Steel 15 | K. DeLong 4 | D. Steel 9 |
| November 22, 2042 | WAKE FOREST DEMON DEACONS Hall of Fame Classic | W 86-77 | 4-0 | J. Nelson 17 | D. Steel 5 | J. Nelson 13 |
| November 23, 2042 | ST. JOHN'S RED STORM Hall of Fame Classic | W 98-79 | 5-0 | O. Keck 23 | D. Steel 3 | D. Steel 8 |
| November 30, 2042 | @ #5 Minnesota Golden Gophers | L 75-91 | 5-1 | K. DeLong 14 | M. Gasco 6 | J. Nelson 6 |
| December 1, 2042 | GEORGE WASHINGTON COLONIALS | W 91-72 | 6-1 | K. DeLong 23 | J. Weston 4 | J. Nelson 14 |
| December 5, 2042 | USC TROJANS | W 76-68 | 7-1 | J. Nelson 15 | K. DeLong 6 | J. Nelson 15 |
| December 8, 2042 | #11 GONZAGA BULLDOGS | L 71-96 | 7-2 | J. Nelson 13 | K. DeLong 3 | J. Nelson 9 |
| December 13, 2042 | #16 MARYLAND TERRAPINS | W 85-70 | 8-2 | J. Nelson 20 | R. Cole 5 | J. Nelson 12 |
| December 19, 2042 | FLORIDA ATLANTIC OWLS | W 100-72 | 9-2 | R. Cole 21 | J. Weston 6 | J. Nelson 7 |
| December 28, 2042 | @ BYU Cougars (7-3, 0-0, 5-0 Home)* | - | | | | |
| January 2, 2043 | UCF KNIGHTS (5-4, 0-0, 0-3 Away)* | - | | | | |
| January 4, 2043 | KANSAS STATE WILDCATS (5-5, 0-0, 1-1 Away)* | - | | | | |
| January 6, 2043 | @ Cincinnati Bearcats (8-2, 0-0, 6-2 Home)* | - | | | | |
| January 9, 2043 | @ Iowa State Cyclones (2-7, 0-0, 2-4 Home)* | - | | | | |
| January 13, 2043 | BAYLOR BEARS (11-1, 0-0, 1-0 Away)* | - | | | | |
| January 18, 2043 | @ Texas Tech Red Raiders (6-4, 0-0, 4-1 Home)* | - | | | | |
| January 20, 2043 | ARIZONA STATE SUN DEVILS (7-3, 0-0, 1-0 Away)* | - | | | | |
| January 25, 2043 | @ UCF Knights (5-4, 0-0, 5-0 Home)* | - | | | | |
| January 27, 2043 | KANSAS JAYHAWKS (10-1, 0-0, 1-1 Away)* | - | | | | |
| February 1, 2043 | OKLAHOMA STATE COWBOYS (10-1, 0-0, 0-0 Away)* | - | | | | |
| February 3, 2043 | @ Colorado Buffaloes (6-4, 0-0, 4-2 Home)* | - | | | | |
| February 8, 2043 | TEXAS TECH RED RAIDERS (6-4, 0-0, 1-2 Away)* | - | | | | |
| February 10, 2043 | @ Kansas State Wildcats (5-5, 0-0, 2-4 Home)* | - | | | | |
| February 15, 2043 | @ Arizona Wildcats (3-6, 0-0, 3-2 Home)* | - | | | | |
| February 20, 2043 | UTAH UTES (7-4, 0-0, 0-0 Away)* | - | | | | |
| February 22, 2043 | HOUSTON COUGARS (7-2, 0-0, 0-2 Away)* | - | | | | |
| February 24, 2043 | @ Arizona State Sun Devils (7-3, 0-0, 5-2 Home)* | - | | | | |
| March 1, 2043 | ARIZONA WILDCATS (3-6, 0-0, 0-4 Away)* | - | | | | |
| March 3, 2043 | @ TCU Horned Frogs (7-3, 0-0, 6-0 Home)* | - | | | | |
