| November 14, 2042 | DUQUESNE DUKES | W 84-50 | 1-0 | J. Nelson 23 | K. DeLong 5 | J. Nelson 21 |
| November 17, 2042 | GEORGIA SOUTHERN EAGLES | W 108-67 | 2-0 | O. Engel 20 | K. DeLong 6 | J. Nelson 12 |
| November 21, 2042 | UNC GREENSBORO SPARTANS Hall of Fame Classic | W 70-43 | 3-0 | D. Steel 15 | K. DeLong 4 | D. Steel 9 |
| November 22, 2042 | WAKE FOREST DEMON DEACONS Hall of Fame Classic | W 86-77 | 4-0 | J. Nelson 17 | D. Steel 5 | J. Nelson 13 |
| November 23, 2042 | ST. JOHN'S RED STORM Hall of Fame Classic | W 98-79 | 5-0 | O. Keck 23 | D. Steel 3 | D. Steel 8 |
| November 30, 2042 | @ #5 Minnesota Golden Gophers | L 75-91 | 5-1 | K. DeLong 14 | M. Gasco 6 | J. Nelson 6 |
| December 1, 2042 | GEORGE WASHINGTON COLONIALS | W 91-72 | 6-1 | K. DeLong 23 | J. Weston 4 | J. Nelson 14 |
| December 5, 2042 | USC TROJANS | W 76-68 | 7-1 | J. Nelson 15 | K. DeLong 6 | J. Nelson 15 |
| December 8, 2042 | #11 GONZAGA BULLDOGS | L 71-96 | 7-2 | J. Nelson 13 | K. DeLong 3 | J. Nelson 9 |
| December 13, 2042 | #16 MARYLAND TERRAPINS | W 85-70 | 8-2 | J. Nelson 20 | R. Cole 5 | J. Nelson 12 |
| December 19, 2042 | FLORIDA ATLANTIC OWLS | W 100-72 | 9-2 | R. Cole 21 | J. Weston 6 | J. Nelson 7 |
| December 28, 2042 | @ BYU Cougars* | W 81-69 | 10-2 | J. Nelson 15 | K. DeLong 7 | J. Nelson 11 |
| January 2, 2043 | UCF KNIGHTS* | W 86-70 | 11-2 | J. Nelson 21 | J. Weston 4 | J. Nelson 17 |
| January 4, 2043 | KANSAS STATE WILDCATS* | W 79-68 | 12-2 | D. Steel 16 | K. DeLong 5 | J. Nelson 9 |
| January 6, 2043 | @ Cincinnati Bearcats* | W 81-72 | 13-2 | J. Nelson 16 | O. Keck 3 | J. Nelson 11 |
| January 9, 2043 | @ Iowa State Cyclones* | W 73-61 | 14-2 | O. Keck 14 | K. DeLong 2 | J. Nelson 10 |
| January 13, 2043 | #1 BAYLOR BEARS* | L 64-79 | 14-3 | J. Weston 20 | K. DeLong 3 | J. Nelson 9 |
| January 18, 2043 | @ Texas Tech Red Raiders* | L 69-83 | 14-4 | K. DeLong 14 | J. Weston 4 | J. Nelson 9 |
| January 20, 2043 | ARIZONA STATE SUN DEVILS* | W 79-71 | 15-4 | O. Keck 13 | J. Weston 5 | D. Steel 8 |
| January 25, 2043 | @ UCF Knights* | L 58-74 | 15-5 | R. Cole 11 | K. DeLong 4 | J. Nelson 6 |
| January 27, 2043 | #3 KANSAS JAYHAWKS* | L 75-80 | 15-6 | J. Nelson 21 | M. Gasco 5 | J. Nelson 13 |
| February 1, 2043 | #18 OKLAHOMA STATE COWBOYS* | W 93-68 | 16-6 | J. Weston 17 | D. Steel 5 | J. Nelson 10 |
| February 3, 2043 | @ Colorado Buffaloes* | W 85-71 | 17-6 | D. Crowell 18 | K. DeLong 7 | J. Nelson 17 |
| February 8, 2043 | TEXAS TECH RED RAIDERS* | W 70-55 | 18-6 | K. DeLong 12 | K. DeLong 3 | J. Nelson 18 |
| February 10, 2043 | @ Kansas State Wildcats* | W 65-57 | 19-6 | J. Weston 12 | O. Keck 3 | J. Nelson 11 |
| February 15, 2043 | @ Arizona Wildcats (5-18, 2-12, 5-7 Home)* | - | | | | |
| February 20, 2043 | UTAH UTES (16-9, 9-5, 4-3 Away)* | - | | | | |
| February 22, 2043 | HOUSTON COUGARS (16-7, 9-5, 4-5 Away)* | - | | | | |
| February 24, 2043 | @ Arizona State Sun Devils (15-9, 8-6, 10-4 Home)* | - | | | | |
| March 1, 2043 | ARIZONA WILDCATS (5-18, 2-12, 0-11 Away)* | - | | | | |
| March 3, 2043 | @ TCU Horned Frogs (15-9, 8-6, 11-2 Home)* | - | | | | |
