| November 16, 2042 | @ #4 North Carolina Tar Heels | L 49-87 | 0-1 | T. Houck 11 | L. Mercier 3 | E. Ramirez 7 |
| November 21, 2042 | @ Ole Miss Rebels Charleston Classic | L 88-101 | 0-2 | E. Ramirez 16 | R. Garber 5 | E. Ramirez 9 |
| November 24, 2042 | @ Oregon State Beavers | L 71-79 | 0-3 | B. Kolb 26 | R. Garber 4 | S. Taylor 7 |
| November 29, 2042 | PRESBYTERIAN BLUE HOSE | W 75-73 | 1-3 | S. Taylor 14 | D. Schaefer 4 | T. Houck 6 |
| December 1, 2042 | PORTLAND STATE VIKINGS | L 76-79 | 1-4 | E. Ramirez 19 | T. Houck 3 | E. Ramirez 10 |
| December 7, 2042 | @ Princeton Tigers | L 72-83 | 1-5 | B. Kolb 14 | R. Garber 6 | E. Ramirez 6 |
| December 9, 2042 | NEW HAMPSHIRE WILDCATS | W 86-76 | 2-5 | T. Houck 23 | R. Garber 4 | E. Ramirez 14 |
| December 13, 2042 | NEVADA WOLFPACK | L 61-88 | 2-6 | E. Ramirez 20 | T. Houck 3 | E. Ramirez 11 |
| December 23, 2042 | SEATTLE REDHAWKS | W 85-68 | 3-6 | T. Houck 20 | R. Garber 8 | E. Ramirez 10 |
| December 26, 2042 | @ UCLA Bruins* | L 63-90 | 3-7 | S. Taylor 24 | T. Houck 4 | S. Taylor 9 |
| December 28, 2042 | #6 MINNESOTA GOLDEN GOPHERS* | L 84-102 | 3-8 | B. Kolb 19 | R. Garber 5 | E. Ramirez 7 |
| January 2, 2043 | @ Michigan Wolverines* | L 61-86 | 3-9 | T. Houck 12 | R. Garber 4 | M. Shields 6 |
| January 4, 2043 | OREGON DUCKS* | L 76-83 | 3-10 | B. Kolb 26 | R. Garber 11 | S. Taylor 7 |
| January 9, 2043 | @ Northwestern Wildcats* | L 60-67 | 3-11 | S. Taylor 12 | R. Garber 5 | E. Ramirez 9 |
| January 11, 2043 | #4 PURDUE BOILERMAKERS* | L 57-71 | 3-12 | E. Ramirez 18 | R. Garber 5 | E. Ramirez 11 |
| January 16, 2043 | OHIO STATE BUCKEYES* | W 62-54 | 4-12 | H. McRae 11 | R. Garber 5 | S. Taylor 10 |
| January 18, 2043 | MICHIGAN STATE SPARTANS* | W 84-77 | 5-12 | B. Kolb 30 | R. Garber 5 | B. Kolb 6 |
| January 23, 2043 | @ #16 Iowa Hawkeyes* | L 73-84 | 5-13 | B. Kolb 19 | R. Garber 5 | E. Ramirez 7 |
| January 25, 2043 | #11 MARYLAND TERRAPINS* | L 75-88 | 5-14 | S. Taylor 15 | R. Garber 5 | E. Ramirez 10 |
| January 30, 2043 | @ Penn State Nittany Lions* | L 86-107 | 5-15 | B. Kolb 26 | R. Garber 7 | L. Mercier 6 |
| February 1, 2043 | @ Wisconsin Badgers* | L 63-71 | 5-16 | S. Taylor 17 | R. Garber 5 | S. Taylor 6 |
| February 6, 2043 | @ Rutgers Scarlet Knights* | L 64-86 | 5-17 | T. Houck 19 | T. Houck 4 | E. Ramirez 10 |
| February 8, 2043 | @ USC Trojans* | L 74-90 | 5-18 | S. Taylor 27 | R. Garber 3 | S. Taylor 7 |
| February 13, 2043 | ILLINOIS FIGHTING ILLINI (16-7, 9-5, 4-6 Away)* | - | | | | |
| February 15, 2043 | INDIANA HOOSIERS (17-8, 10-4, 5-6 Away)* | - | | | | |
| February 20, 2043 | NEBRASKA CORNHUSKERS (5-18, 2-12, 0-8 Away)* | - | | | | |
| February 22, 2043 | @ Ohio State Buckeyes (6-17, 2-12, 6-8 Home)* | - | | | | |
| February 27, 2043 | UCLA BRUINS (9-15, 4-10, 1-7 Away)* | - | | | | |
| March 1, 2043 | @ Illinois Fighting Illini (16-7, 9-5, 12-1 Home)* | - | | | | |
