| November 16, 2042 | HIGH POINT PANTHERS | L 77-81 | 0-1 | S. Crockett 19 | S. Crockett 4 | J. Hester 7 |
| November 19, 2042 | @ Temple Owls | W 78-67 | 1-1 | S. Crockett 16 | N. Lyall 5 | N. Lyall 6 |
| November 21, 2042 | @ St. Bonaventure Bonnies Hall of Fame Classic | W 75-72 | 2-1 | V. Winter 13 | S. Crockett 5 | V. Winter 7 |
| November 22, 2042 | @ #11 West Virginia Mountaineers Hall of Fame Classic | L 77-86 | 2-2 | K. Lewandowski 16 | S. Crockett 3 | S. Crockett 5 |
| November 26, 2042 | SAN DIEGO STATE AZTECS | L 70-84 | 2-3 | S. Crockett 16 | J. Hester 4 | J. Hester 3 |
| November 29, 2042 | @ Kentucky Wildcats | L 61-76 | 2-4 | S. Crockett 10 | K. Lewandowski 4 | J. Hester 8 |
| December 3, 2042 | @ Fordham Rams | L 74-90 | 2-5 | T. Stock 17 | S. Crockett 3 | D. Pruitt 4 |
| December 7, 2042 | FRESNO STATE BULLDOGS | L 76-100 | 2-6 | S. Phillips 17 | F. Collins 5 | N. Lyall 5 |
| December 13, 2042 | @ Davidson Wildcats | W 89-59 | 3-6 | S. Crockett 19 | S. Crockett 6 | J. Hester 8 |
| December 20, 2042 | @ Missouri Tigers | L 64-86 | 3-7 | V. Winter 13 | S. Crockett 5 | J. Hester 7 |
| December 26, 2042 | @ California Golden Bears* | L 66-88 | 3-8 | D. Pruitt 11 | S. Crockett 3 | V. Winter 9 |
| December 28, 2042 | @ #8 Stanford Cardinal* | L 74-78 | 3-9 | K. Lewandowski 22 | S. Crockett 12 | J. Hester 8 |
| January 2, 2043 | #13 LOUISVILLE CARDINALS* | W 92-58 | 4-9 | S. Crockett 16 | S. Crockett 6 | J. Hester 10 |
| January 4, 2043 | #22 FLORIDA STATE SEMINOLES* | L 70-80 | 4-10 | T. Stock 15 | S. Crockett 6 | K. Lewandowski 4 |
| January 9, 2043 | NC STATE WOLFPACK* | W 69-59 | 5-10 | K. Lewandowski 14 | S. Crockett 6 | J. Hester 7 |
| January 11, 2043 | CLEMSON TIGERS* | L 62-73 | 5-11 | V. Winter 14 | K. Lewandowski 2 | N. Lyall 6 |
| January 16, 2043 | @ SMU Mustangs* | L 85-93 | 5-12 | K. Lewandowski 21 | S. Crockett 3 | N. Lyall 6 |
| January 18, 2043 | BOSTON COLLEGE EAGLES* | L 78-86 OT | 5-13 | J. Hester 14 | S. Crockett 4 | V. Winter 9 |
| January 23, 2043 | DUKE BLUE DEVILS* | L 66-74 | 5-14 | S. Crockett 17 | K. Lewandowski 5 | V. Winter 6 |
| January 25, 2043 | VIRGINIA CAVALIERS* | W 75-66 | 6-14 | T. Stock 15 | K. Lewandowski 3 | J. Hester 10 |
| January 30, 2043 | @ Syracuse Orange* | L 47-83 | 6-15 | S. Phillips 12 | N. Lyall 2 | V. Winter 7 |
| February 1, 2043 | @ Miami (FL) Hurricanes* | L 61-74 | 6-16 | K. Lewandowski 12 | C. Carey 4 | D. Pruitt 5 |
| February 6, 2043 | #11 NOTRE DAME FIGHTING IRISH* | L 72-88 | 6-17 | V. Winter 20 | S. Crockett 4 | V. Winter 5 |
| February 8, 2043 | @ #1 North Carolina Tar Heels* | L 48-84 | 6-18 | S. Crockett 12 | J. Hester 2 | J. Hester 7 |
| February 13, 2043 | @ Virginia Tech Hokies (4-20, 0-14, 3-9 Home)* | - | | | | |
| February 15, 2043 | PITTSBURGH PANTHERS (15-10, 8-6, 3-6 Away)* | - | | | | |
| February 20, 2043 | GEORGIA TECH YELLOW JACKETS (16-9, 8-6, 4-6 Away)* | - | | | | |
| February 22, 2043 | @ Pittsburgh Panthers (15-10, 8-6, 9-4 Home)* | - | | | | |
| February 27, 2043 | @ Virginia Cavaliers (9-14, 7-7, 6-4 Home)* | - | | | | |
| March 1, 2043 | @ Florida State Seminoles (14-9, 7-7, 11-2 Home)* | - | | | | |
