| November 16, 2042 | CAL POLY MUSTANGS | W 79-75 | 1-0 | C. Dix 17 | C. Allen 6 | C. Ewing 10 |
| November 19, 2042 | WEST GEORGIA WOLVES | W 88-72 | 2-0 | S. Simms 16 | C. Allen 5 | K. Smith 10 |
| November 21, 2042 | NORTHERN ARIZONA LUMBERJACKS Charleston Classic | W 93-72 | 3-0 | C. Allen 15 | C. Ewing 4 | C. Ewing 9 |
| November 22, 2042 | OLE MISS REBELS Charleston Classic | L 79-91 | 3-1 | S. Simms 17 | D. Linder 6 | K. Smith 8 |
| November 26, 2042 | #12 NC STATE WOLFPACK | W 79-71 | 4-1 | S. Simms 16 | C. Allen 6 | C. Ewing 7 |
| November 30, 2042 | JAMES MADISON DUKES | W 86-73 | 5-1 | K. Smith 17 | C. Dix 4 | K. Smith 11 |
| December 3, 2042 | ARKANSAS PINE BLUFF GOLDEN LIONS | W 95-72 | 6-1 | J. Killion 22 | S. Simms 5 | C. Ewing 11 |
| December 7, 2042 | NORTHERN ILLINOIS HUSKIES | W 83-66 | 7-1 | S. Simms 24 | S. Pease 3 | C. Ewing 8 |
| December 13, 2042 | @ Cincinnati Bearcats | L 66-74 | 7-2 | C. Ewing 16 | S. Simms 5 | C. Ewing 10 |
| December 21, 2042 | @ Texas A&M Aggies | W 90-86 | 8-2 | C. Ewing 19 | J. Killion 4 | C. Ewing 7 |
| December 26, 2042 | @ St. John's Red Storm (6-5, 0-0, 4-1 Home)* | - | | | | |
| December 30, 2042 | CREIGHTON BLUE JAYS (9-2, 0-0, 3-1 Away)* | - | | | | |
| January 2, 2043 | @ Georgetown Hoyas (2-8, 0-0, 1-1 Home)* | - | | | | |
| January 4, 2043 | MARQUETTE GOLDEN EAGLES (5-4, 0-0, 1-1 Away)* | - | | | | |
| January 11, 2043 | @ DePaul Blue Demons (3-7, 0-0, 2-5 Home)* | - | | | | |
| January 13, 2043 | @ Seton Hall Pirates (8-1, 0-0, 8-0 Home)* | - | | | | |
| January 20, 2043 | PROVIDENCE FRIARS (4-5, 0-0, 1-2 Away)* | - | | | | |
| January 23, 2043 | BUTLER BULLDOGS (6-4, 0-0, 1-2 Away)* | - | | | | |
| January 27, 2043 | @ Villanova Wildcats (5-4, 0-0, 4-2 Home)* | - | | | | |
| January 30, 2043 | @ Connecticut Huskies (7-4, 0-0, 4-1 Home)* | - | | | | |
| February 1, 2043 | @ Marquette Golden Eagles (5-4, 0-0, 4-2 Home)* | - | | | | |
| February 3, 2043 | SETON HALL PIRATES (8-1, 0-0, 0-1 Away)* | - | | | | |
| February 8, 2043 | DEPAUL BLUE DEMONS (3-7, 0-0, 0-1 Away)* | - | | | | |
| February 10, 2043 | @ Creighton Blue Jays (9-2, 0-0, 3-1 Home)* | - | | | | |
| February 15, 2043 | VILLANOVA WILDCATS (5-4, 0-0, 1-1 Away)* | - | | | | |
| February 17, 2043 | CONNECTICUT HUSKIES (7-4, 0-0, 1-2 Away)* | - | | | | |
| February 22, 2043 | @ Providence Friars (4-5, 0-0, 3-2 Home)* | - | | | | |
| February 24, 2043 | @ Butler Bulldogs (6-4, 0-0, 4-1 Home)* | - | | | | |
| March 1, 2043 | ST. JOHN'S RED STORM (6-5, 0-0, 0-3 Away)* | - | | | | |
| March 3, 2043 | GEORGETOWN HOYAS (2-8, 0-0, 0-6 Away)* | - | | | | |
