| November 16, 2042 | CAL POLY MUSTANGS | W 79-75 | 1-0 | C. Dix 17 | C. Allen 6 | C. Ewing 10 |
| November 19, 2042 | WEST GEORGIA WOLVES | W 88-72 | 2-0 | S. Simms 16 | C. Allen 5 | K. Smith 10 |
| November 21, 2042 | NORTHERN ARIZONA LUMBERJACKS Charleston Classic | W 93-72 | 3-0 | C. Allen 15 | C. Ewing 4 | C. Ewing 9 |
| November 22, 2042 | OLE MISS REBELS Charleston Classic | L 79-91 | 3-1 | S. Simms 17 | D. Linder 6 | K. Smith 8 |
| November 26, 2042 | #12 NC STATE WOLFPACK | W 79-71 | 4-1 | S. Simms 16 | C. Allen 6 | C. Ewing 7 |
| November 30, 2042 | JAMES MADISON DUKES | W 86-73 | 5-1 | K. Smith 17 | C. Dix 4 | K. Smith 11 |
| December 3, 2042 | ARKANSAS PINE BLUFF GOLDEN LIONS | W 95-72 | 6-1 | J. Killion 22 | S. Simms 5 | C. Ewing 11 |
| December 7, 2042 | NORTHERN ILLINOIS HUSKIES | W 83-66 | 7-1 | S. Simms 24 | S. Pease 3 | C. Ewing 8 |
| December 13, 2042 | @ Cincinnati Bearcats | L 66-74 | 7-2 | C. Ewing 16 | S. Simms 5 | C. Ewing 10 |
| December 21, 2042 | @ Texas A&M Aggies | W 90-86 | 8-2 | C. Ewing 19 | J. Killion 4 | C. Ewing 7 |
| December 26, 2042 | @ St. John's Red Storm* | W 102-88 | 9-2 | C. Dix 28 | J. Killion 8 | C. Ewing 10 |
| December 30, 2042 | #17 CREIGHTON BLUE JAYS* | L 65-72 | 9-3 | S. Simms 13 | C. Ewing 2 | K. Smith 8 |
| January 2, 2043 | @ Georgetown Hoyas* | L 69-77 | 9-4 | S. Simms 12 | S. Simms 5 | C. Ewing 14 |
| January 4, 2043 | MARQUETTE GOLDEN EAGLES* | W 81-76 | 10-4 | K. Smith 23 | S. Simms 6 | C. Ewing 7 |
| January 11, 2043 | @ DePaul Blue Demons* | W 80-74 OT | 11-4 | S. Simms 15 | C. Allen 3 | C. Ewing 14 |
| January 13, 2043 | @ #22 Seton Hall Pirates* | L 73-98 | 11-5 | C. Dix 17 | C. Allen 6 | C. Ewing 10 |
| January 20, 2043 | PROVIDENCE FRIARS* | L 84-97 | 11-6 | C. Ewing 14 | C. Allen 5 | C. Ewing 14 |
| January 23, 2043 | #12 BUTLER BULLDOGS* | L 66-92 | 11-7 | D. Whaley 18 | C. Allen 3 | K. Smith 9 |
| January 27, 2043 | @ Villanova Wildcats* | L 74-82 | 11-8 | C. Ewing 24 | B. Bergmann 4 | C. Ewing 9 |
| January 30, 2043 | @ Connecticut Huskies* | L 74-85 | 11-9 | S. Simms 16 | C. Allen 6 | K. Smith 8 |
| February 1, 2043 | @ Marquette Golden Eagles* | L 89-99 | 11-10 | C. Ewing 16 | S. Pease 7 | K. Smith 5 |
| February 3, 2043 | #21 SETON HALL PIRATES* | W 104-100 OT | 12-10 | C. Dix 16 | C. Allen 7 | K. Smith 7 |
| February 8, 2043 | DEPAUL BLUE DEMONS* | W 85-72 | 13-10 | B. Bergmann 22 | C. Allen 6 | C. Ewing 9 |
| February 10, 2043 | @ #21 Creighton Blue Jays* | L 94-100 | 13-11 | S. Pease 15 | S. Pease 4 | C. Ewing 9 |
| February 15, 2043 | VILLANOVA WILDCATS (9-15, 4-11, 1-8 Away)* | - | | | | |
| February 17, 2043 | CONNECTICUT HUSKIES (16-10, 9-6, 4-6 Away)* | - | | | | |
| February 22, 2043 | @ Providence Friars (9-14, 5-9, 6-7 Home)* | - | | | | |
| February 24, 2043 | @ Butler Bulldogs (20-4, 14-0, 11-1 Home)* | - | | | | |
| March 1, 2043 | ST. JOHN'S RED STORM (9-17, 3-12, 0-10 Away)* | - | | | | |
| March 3, 2043 | GEORGETOWN HOYAS (8-17, 6-9, 3-11 Away)* | - | | | | |
